Promoter
Association of IL-4 promoter polymorphisms with asthma: a meta-analysis
Authors: L. Tang, H.G. Lin and B.F. Chen
This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that t.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.11
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.11
Characterization of FeDREB1 promoter involved in cold- and drought-inducible expression from common buckwheat (Fagopyrum esculentum)
Authors: Z.W. Fang, X.Y. Xu, J.F. Gao, P.K. Wang, Z.X. Liu and B.L. Feng
C-repeat-binding factor (CBF)/dehydration-responsive element (DREB) transcription factors play key roles in plant stress responses. However, little information is available on the regulation of CBF/DREB expression. In this study, we isolated and characterized the FeDREB1 promoter sequence from the common buckwheat accession Xinong 9976. To identify the up.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.7
- DOI:
- 10.4238/2015.July.17.7
Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients
Authors: G.L. Shi, X.L. Hu, L. Yang, C.L. Rong, Y.L. Guo and C.X. Song
Human leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4+ T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associ.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1132
- DOI:
- 10.4238/vol10-3gmr1132
Synergistic and threshold effects of GH1 and GHR promoter size variation on body growth and fat accrual in young Nelore (Bos indicus) bulls
Authors: M.A. Dani, M. von Cube, I.L. Freire, L. Suguisawa, C. Fischer, S.U. Dani
A synergistic effect in the somatotropic axis (GH1-GHR-IGF1) was observed in 736 young Nelore (Bos indicus) bulls under ad libitum grass feeding conditions on irrigated pasture in central Brazil. Stepwise substitution of shorter alleles of the promoter region of the growth hormone gene (GH1) and the P1 promoter of the GH1 rece.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.11
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.11
An enhancer/promoter combination strengthens the expression of blood-coagulation factor VIII in non-viral expression vectors
Authors: V. Pican�?§o-Castro, E.M.S. Russo-Carbolante, A.M. Fontes,A.C. Fernandes and D.T. Covas
We explored the potential of fusion of hepatic locus control region 1 (HCR-1) with HCR-2 to express B-domain-deleted human factor VIII (FVIII) in four cell lines. B-domain-deleted human FVIII expression was controlled by HCR-1/HCR-2, followed by liver specific and ubiquitous promoters. Chimera enhancer HCR-1/HCR-2, followed by.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr447
- DOI:
- 10.4238/vol7-2gmr447
A promoter trap vector for knocking out bovine myostatin gene with high targeting efficiency
Authors: L.H. Zhao, Y.H. Zhao, H. Liang, T. Yun, X.J. Han, M.L. Zhang, X. Zhou, D.X. Hou, R.F. Li and X.L. Li
With the development of gene targeting approaches, genomic mutation technologies in livestock animals such as gene trapping, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats and their associated systems have been improved. Although ZFNs have been used for gene targ.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.5
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.5
Promoter methylation and histone modifications affect the expression of the exogenous DsRed gene in transgenic goats
Authors: M.T. Nuo, J.L. Yuan, W.L. Yang, X.Y. Gao, N. He, H. Liang, M. Cang and D.J. Liu
Transgene silencing, which is common in transgenic plants and animals, limits the generation and application of genetically modified organisms, and is associated with the exogenous gene copy number, the methylation status of its promoters, and histone modification abnormalities. Here, we analyzed the expression of the exogenou.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038560
- DOI:
- 10.4238/gmr.15038560
Molecular characterization, expression patterns, and promoter activity analysis of PGM1 in pigs
Authors: J.Y. Yu, S.M. Shao and Y.Z. Xiong
The phosphoglucomutase 1 (PGM1) gene was differentially expressed in tissues of Chinese Meishan and Large White pigs. In this study, the promoter region, expression profile, and genetic mutations of the gene were determined. Expression of a 5'-deletion in both C2C12 and PK-15 cells showed that a negative regulatory element was at -1871 .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.12
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.12
Intrinsically bent DNA in replication origins and gene promoters
Authors: F. Gimenes, K.I. Takeda, A. Fiorini, F.S. Gouveia and M.A. Fernandez
Intrinsically bent DNA is an alternative conformation of the DNA molecule caused by the presence of dA/dT tracts, 2 to 6 bp long, in a helical turn phase DNA or with multiple intervals of 10 to 11 bp. Other than flexibility, intrinsic bending sites induce DNA curvature in particular chromosome regions such as replication origi.. Read More»
- Genet. Mol. Res. 7(2):
- vol7-2gmr461
- DOI:
- 10.4238/vol7-2gmr461
Isolation and characterization of the organ-specific and light-inducible promoter of the gene encoding rubisco activase in potato (Solanum tuberosum)
Authors: D. Qu, Y. Song, W.M. Li, X.W. Pei, Z.X. Wang, S.R. Jia and Y.Q. Zhang
Constitutive promoters have been widely used in crop biotechnology applications. Tissue-specific or inducible promoters, however, have advantages in some cases. We isolated the 731-bp 5' flanking sequence of a potato (Solanum tuberosum) gene, encoding ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) activase (RCA), wh.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1088
- DOI:
- 10.4238/vol10-2gmr1088