Promoter
Polymorphisms in the leptin gene promoter in Brazilian beef herds
Authors: R.C. Guimar�£es, J.S.N. Azevedo, S.C. Corr�ªa, J.E.G. Campelo, E.M. Barbosa, E.C. Gon�§alves and E. Silva Filho
Brazil is the world’s largest producer of beef cattle; however, the quality of its herds needs to be improved. The use of molecular markers as auxiliary tools in selecting animals for reproduction with high pattern for beef production would significantly improve the quality of the final beef product in Brazil. The leptin.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048981
- DOI:
- 10.4238/gmr15048981
Isolation and partial characterization of a root-specific promoter for stacking multiple traits into cassava (Manihot esculenta CRANTZ)
Authors: M.A. Gbadegesin and J.R. Beeching
Cassava can be cultivated on impoverished soils with minimum inputs, and its storage roots are a staple food for millions in Africa. However, these roots are low in bioavailable nutrients and in protein content, contain cyanogenic glycosides, and suffer from a very short post-harvest shelf-life, and the plant is susceptible to.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr892
- DOI:
- 10.4238/vol10-2gmr892
Regulation of WNK4 gene transcription in the kidneys
Authors: Z.J. Sun, Y. Li, Y.H. Li, J.S. Zhang, Q. Ding, J. Li-Ling, Y. Liang and Y.Y. Zhao
With-no-lysine (K) kinase-4 (WNK4) is a newly cloned kinase-encoding gene that plays a crucial role in the maintenance of electrolyte homeostasis. Mutations of WNK4 can cause pseudohypoaldosteronism type α, an autosomal dominant disease characterized by hyperkalemia, metabolic acidosis and hypertension. We explored the expression and regulatory mech.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.9
- DOI:
- 10.4238/2013.January.4.9
IL-10 promoter SNPs and susceptibility to leprosy in ethnic groups from southwest China
Authors: X.H. Chen, J.H. Xiong, Y. Ning, Y. Wen, J. Liu, C. Mao, X.M. Weng and J.C. Gu
The purpose of this study was to determine whether interleukin-10 (IL-10) promoter polymorphisms are associated with leprosy or their subtypes in ethnic groups from southwest China. Genotyping using TaqMan® SNP Genotyping Master Mix and ABI 7500 real-time PCR system was performed for IL-10 T3575A, G2849A, C2763A, A1082G, C.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.3
- DOI:
- 10.4238/2013.August.12.3
BacPP: a web-based tool for Gram-negative bacterial promoter prediction
Authors: S. de Avila e Silva, D.L. Notari, F.A. Neis, H.G. Ribeiro and S. Echeverrigaray
Bacterial Promoter Prediction (BacPP) is a tool used to predict given sequences as promoters of Gram-negative bacteria according to the σ factor that recognizes it. The first version of BacPP was implemented in Python language in a desktop version without a friendly interface. For this reason, a web version of BacPP is n.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027973
- DOI:
- 10.4238/gmr.15027973
Bioinformatic analysis based on the complete coding region of the MSTN gene within and among different species
Authors: X.C. Song, C. Xu, Z.G. Yue, L. Wang, G.W. Wang and F.H. Yang
Myostatin, encoded by the MSTN gene (previously GDF8), is a member of the transforming growth factor-β superfamily, which normally acts to limit skeletal muscle mass by regulating the number and growth of muscle fibers. In this study, a total of 84 myostatin gene sequences with known complete coding regions (CDS) and corr.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025031
- DOI:
- 10.4238/gmr.15025031
Association between RASSF1A promoter methylation and renal cell cancer susceptibility: a meta-analysis
Authors: Y.Q. Huang, H. Guan, C.H. Liu,D.C. Liu, B. Xu, L. Jiang, Z.X. Lin and M. Chen
Epigenetic inactivation of Ras-associated domain family 1A (RASSF1A) by hyper-methylation of its promoter region has been identified in various cancers. However, the role of RASSF1A in renal cancer has neither been thoroughly investigated nor reviewed. In this study, we reviewed and performed a meta-analysis of 13 published st.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026994
- DOI:
- 10.4238/gmr.15026994
Comparative analysis of myostatin gene and promoter sequences of Qinchuan and Red Angus cattle
Authors: Y.L. He, Y.H. Wu, F.S. Quan, Y.G. Liu and Y. Zhang
To better understand the function of the myostatin gene and its promoter region in bovine, we amplified and sequenced the myostatin gene and promoter from the blood of Qinchuan and Red Angus cattle by using polymerase chain reaction. The sequences of Qinchuan and Red Angus cattle were compared with those of other cattle breeds available in GenBank. Exon s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.4.6
- DOI:
- 10.4238/2013.September.4.6
Polymorphisms in promoter regions of IL-6 and IL-10 genes in breast cancer: a case-control study
Authors: E.S. AlSuhaibani, N.A. Kizilbash, S. Malik, J.I. Dasti, F. Al Beladi and N. El-Morshedi
Polymorphisms in interleukin genes (IL-6 and IL-10) are involved in the pathogenesis of breast cancer. This study investigated polymorphisms in the promoter regions of IL-6 (-174G/C) and IL-10 (-1082G/A) through a case-control study employing 80 female subjects who were pathologically diagnosed with breast cancer. All patients received follow-up care at t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017360
- DOI:
- 10.4238/gmr.15017360
Molecular cloning, polymorphisms, and association analysis of the promoter region of the STAM2 gene in Wuchuan Black cattle
Authors: Y.-Q. Yang, Y.-T. Hui, R.-Y. Liu, R.-G. Jiao, Y. Gong, Y.-Y. Zhang and H.-Q. Xie
The STAM protein plays an important role in the cytokine-related JAK/STAT pathway. We selected the STAM2 gene as a candidate gene that could be linked to growth performance in analysis of a Chinese cattle breed (Wuchuan Black cattle). We examined genetic variants in the promoter region of the STAM2 gene and their associations with eight growth traits in 1.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.9
- DOI:
- 10.4238/2013.September.13.9