Promoter
Breeding of transgenic cattle for human coagulation factor IX by a combination of lentiviral system and cloning
Authors: P.S. Monzani, J.R. Sangalli, T.H.C. De Bem, F.F. Bressan, P. Fantinato-Neto, J.R.V. Pimentel, E.H. Birgel-Junior, A.M. Fontes, D.T. Covas and F.V. Meirelles
Recombinant coagulation factor IX must be produced in mammalian cells because FIX synthesis involves translational modifications. Human cell culture-based expression of human coagulation factor IX (hFIX) is expensive, and large-scale production capacity is limited. Transgenic animals may greatly increase the yield of therapeutic proteins and reduce costs... Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.25
- DOI:
- 10.4238/2013.February.28.25
Mapping and validation of Xanthomonas citri subsp citri genes regulated by putative plant-inducible promoter box (PIP-box)
Authors: F.M.S. Carvalho, J.C.F. Oliveira, M.L. Laia, T.R. Jacob,R.M. Ferreira, M.I.T. Ferro, R.I.D. Tezza, S.M. Zingaretti, C.F. Silva and J.A. Ferro
Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), is a major disease affecting citriculture worldwide, because of the susceptibility of the host and the lack of efficient control methods. Previous studies have reported that some genes of phytopathogenic bacteria possess a consensus nucle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028428
- DOI:
- 10.4238/gmr.15028428
Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis
Authors: Q.F. Li, Q.Y. Li, A.R. Gao and Q.F. Shi
Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching the Cochrane Library, CBM, EMBASE, PubMed, and the Web of Science, we tabul.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.19
- DOI:
- 10.4238/2015.June.18.19
Molecular cloning and analysis of a receptor-like promoter of Gbvdr3 gene in sea island cotton
Authors: B.-J. Zhang, H.-P. Zhang, Q.-Z. Chen, N. Tang, L.-K. Wang, R.-F. Wang and B.-L. Zhang
Verticillium wilt caused by soil borne fungus Verticillium dahliae could significantly reduce cotton yield. The Ve1 homologous gene Gbvdr3 is resistant to Verticillium wilt. In order to understand of the function of the promoter Gbvdr3 in Gossypium barbadense, the promoter region of the receptor-like gene Gbvdr3 was obtained b.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028636
- DOI:
- 10.4238/gmr.15028636
Comparative analysis of MIR168 promoters in three plant species
Authors: D. Qu, F. Yan M.A. Li, C. Varotto and Z.Y. Zhao
MicroRNAs (miRNAs) play important roles in the regulation of gene expression by post-transcriptionally targeting mRNAs for cleavage or translational repression. miR168 is a key miRNA because it regulates the expression of the slicer protein ARGONAUTE1 (AGO1), which catalyzes mRNA cleavage. Interestingly, plant miR168s are high.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027684
- DOI:
- 10.4238/gmr.15027684
Isolation and characterization of Calcineurin B-like gene (PbCBL1) and its promoter in birch-leaf pear (Pyrus betulifolia Bunge)
Authors: Y.Y. Xu, H. Li, J. Lin, X.G. Li and Y.H. Chang
Calcium plays a critical role in regulating abiotic stress responses in plants. Calcineurin B-like (CBL) proteins are calcium sensors in calcium signaling pathways. However, the molecular mechanisms underlying calcium signaling remain to be elucidated. In this study, the CBL1 gene, which codes for the CBL protein, was isolated from the birch-leaf pear. On.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.3
- DOI:
- 10.4238/2015.December.14.3
Promoter analysis of bovine cardiomyopathy-associated protein 1 gene
Authors: G.N. Sui, Z.W. Liu, T. Wang, X. Li, X.B. Ding, X.F. Liu and H. Guo
The CMYA1 (cardiomyopathy-associated protein 1) is an actin-binding protein that plays a vital role in cardiac morphogenesis. CMYA1 is expressed specifically in the myocardial and skeletal muscle and is up-regulated in injured muscle. We therefore speculated that the bovine CMYA1 promoter might be muscle-specific. In this stud.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027675
- DOI:
- 10.4238/gmr.15027675
Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer
Authors: Z.Y. Pan, Z.S. Jiang and H.Q. Ouyang
We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.14
- DOI:
- 10.4238/2015.August.19.14
Isolation and characterization of a chalcone isomerase gene promoter from potato cultivars
Authors: M. Chen, W.J. Zhu, X. You, Y.D. Liu, G.M. Kaleri and Q. Yang
Chalcone isomerase (CHI) is a key enzyme involved in anthocyanin metabolism. Previous research on CHI has mainly focused on cDNA cloning and gene expression. In the current study, the 1425-bp potato CHI promoter (PCP) was isolated from four potato cultivars (Heijingang, Zhongshu 7, Désirée, and Favorita) using PCR and DNA sequencing. The PCP.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.37
- DOI:
- 10.4238/2015.December.28.37
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis
Authors: Y.-F. Yu, Z.-G. Han, W.-B. Guo, G.-J. Zhang, J.-K. Yang, F.-L. Wu, Q.-Y. Ou, Y.-H. Li, X.-Y. Cai, Z.-N. Zhan, J.-H. Chen, W.-L. Xie, L. Tang and C.-D. Liu
It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.1
- DOI:
- 10.4238/2015.December.29.1