Proteomics
Proteomic analysis identifies differentially expressed proteins participating in forming Type III brush hair in Yangtze River Delta white goat
Authors: B. Yang, M.Y. Cai, Y.J. Li, H. Zhang, G.H. Cheng, J.H. Zhang, G.J. Zhang, W.T. Li and D.J. Ji
The Yangtze River Delta white goat is a goat breed that can produce high quality brush hair (Type III hair) around the world. This study aimed to compare Type III hair and non-Type III hair goat skin tissues using differentially expressed proteins based on 2-dimensional gel electrophoresis technology. The differentially expressed protein spots were analyz.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.6
- DOI:
- 10.4238/2015.January.23.6
Serum proteomic spectral characteristics of acute myeloid leukemia and their clinical significance
Authors: R.-J. Zheng, R.-J. Wu and X.-D. Ma
We investigated the differences between the serum proteomic spectral characteristics of acute myeloid leukemia (AML) patients and those of healthy people. We collected peripheral blood serum samples from 62 AML patients and 15 healthy controls. After removing high-abundance proteins, low-abundance serum proteins were separated.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029172
- DOI:
- 10.4238/gmr16029172
Application of genomics and proteomics in drug target discovery
Authors: H.M. Zhang, Z.R. Nan, G.Q. Hui, X.H. Liu and Y. Sun
Gene medicine is making breakthroughs in health questions that have baffled humanity for centuries. To understand and utilize gene medicine, it is necessary to realize its action against targets at the molecular level. Currently, many methods can be used to discover drug targets; among these, genomic and proteomic methods are .. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.10.11
- DOI:
- 10.4238/2014.January.10.11
Proteomic analysis of non-tumoral breast tissue
Authors: G.G. Costa, R. Kaviski, L.E.R. Souza, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is a complex and heterogeneous disease. In spite of the advances made in recent decades, a better understanding of the intrinsic mechanisms of this disease is crucial. The development of new biomarkers is absolutely necessary to improve diagnosis and prognosis. Research using the proteomic approach has generated .. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.3.3
- DOI:
- 10.4238/2011.October.3.3
BNDb - Biomolecules Nucleus Database: an integrated proteomics and transcriptomics database
Authors: Faria-Campos AC, Gomes RR, Moratelli FS, Rausch-Fernandes H, Franco GR and Campos SVA
Proteomics correspond to the identification and quantitative analysis of proteins expressed in different conditions or life stages of a cell or organism. Methods used in proteomics analysis include mainly chromatography, two-dimensional electrophoresis and mass spectrometry. Data generated in proteomics analysis vary significa.. Read More»
- Genet. Mol. Res. 6(4):
Expression of genes related to tolerance to low temperature for maize seed germination
Authors: I.C. Silva-Neta, E.V. Pinho, A.D. Veiga, R.G. P�¬nho, R.M. Guimar�£es, F. Caixeta, H.O. Santos and T.L. Marques
The aim of this study was to characterize maize lines tolerant to cold temperatures during the germination process. Seeds from lines with different levels of tolerance to low temperatures were used; 3 lines were classified as tolerant and 3 as susceptible to low germination temperatures. A field was set up to multiply seeds from selected lines. After the .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.28
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.28
Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model
Authors: Y. Zhao, Y. Zhang, H.B. Song, F. Wu, X.L. Wang, S.-C. Sun, T.X. Cui and D.Q. Tang
The aim of this study was to compare the proteomics pattern of the kidneys from Cyld knockout mice with that from normal mouse kidneys and establish a preliminary understanding of the role of Cyld in the kidney. Proteins from the kidneys of knockout Cyld mice and wild-type mice were extracted, isobaric tags for relative and absolute quantitation (iTRAQ) w.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.14
- DOI:
- 10.4238/2015.June.1.14
Comparative proteomic analysis of ductal and lobular invasive breast carcinoma
Authors: N.C.S. Oliveira, T.H.B. Gomig, H.H. Milioli, F. Cordeiro, G.G. Costa, C.A. Urban, R.S. Lima, I.J. Cavalli and E.M.S.F. Ribeiro
Breast cancer is the second most common cancer worldwide and the first among women. Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the two major histological subtypes, and the clinical and molecular differences between them justify the search for new markers to distinguish them. As proteomic analysis .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027701
- DOI:
- 10.4238/gmr.15027701
Method for obtaining high-resolution proteomic analysis from pericarps of guarana
Authors: A.L. Souza, P.C.S. Angelo, P.P.O. Nogueira, J.F.C. Gon�§alves, A.M. Franco, S. Astolfi-Filho, J.L. L�³pez-Lozano and E.V. Andrade
Guarana has great agricultural potential and is largely used therapeutically and in the production of non-alcoholic energy drinks. Genomic and proteomic studies are crucial to identify proteins that play central roles in the maintenance and viability of fruits, as well as to identify proteins related to the main metabolic path.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.14
- DOI:
- 10.4238/2014.September.29.14
Genes related to high temperature tolerance during maize seed germination
Authors: S.M.F. Dutra, E.V.R. Von Pinho, H.O. Santos, A.C. Lima, R.G. Von Pinho and M.L.M. Carvalho
The identification of genes related to heat tolerance is fundamental for the development of high-quality seeds that are tolerant to heat stress condition. The objective of this study was to evaluate maize lineages and the gene expression involved in high temperature tolerance during germination using physiological tests, proteomics, and transcriptome anal.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.31
- DOI:
- 10.4238/2015.December.22.31