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Pulmonary Tuberculosis

Human Genetics   Research Article

Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population

Authors: G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu

Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In a.. Read More»

Genet. Mol. Res. 16(3):
gmr16039697
DOI:
10.4238/gmr16039697
Human Genetics   Research Article

Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han

Authors: C. Lu, Y.-J. Shen, Y.-F. Deng, C.-Y. Wang, G. Fan1, Y.-Q. Liu, S.-M. Zhao, B.-C. Zhang, Y.-R. Zhao, Z.-E. Wang, C.-Z. Zhang and Z.-M. Lu

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese H.. Read More»

Genet. Mol. Res. 11(2):
2012.May.15.7
DOI:
10.4238/2012.May.15.7
Human Genetics   Research Article

Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients

Authors: G.L. Shi, X.L. Hu, L. Yang, C.L. Rong, Y.L. Guo and C.X. Song

Human leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4+ T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associ.. Read More»

Genet. Mol. Res. 10(3):
vol10-3gmr1132
DOI:
10.4238/vol10-3gmr1132
Human Genetics   Research Article

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Authors: G.-C. Shi and L.-G. Zhang

We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs.. Read More»

Genet. Mol. Res. 14(3):
2015.July.28.22
DOI:
10.4238/2015.July.28.22
Microbial Genetics   Research Article

Associations between tumor necrosis factor-�± polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis

Authors: Y.H. Lee and G.G. Song

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with .. Read More»

Genet. Mol. Res. 14(3):
2015.July.31.8
DOI:
10.4238/2015.July.31.8
Medical Genetics   Research Article

Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Authors: Y.H. Lee and G.G. Song

The aim of this study was to determine whether vitamin D receptor (VDR) genetic polymorphisms are associated with the susceptibility to pulmonary tuberculosis (PTB). MEDLINE and Embase databases and manual literature searches were used. A meta-analysis was conducted on the associations between the VDR FokI, TaqI, BsmI, and ApaI polymorphisms and PTB susce.. Read More»

Genet. Mol. Res. 14(3):
2015.August.7.21
DOI:
10.4238/2015.August.7.21
Human Genetics   Research Article

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Authors: F.M. Feng, X.X. Liu, Y.H. Sun, P. Zhang, S.F. Sun, B. Zhang, X.T. Wang and L.J. Lu

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using pol.. Read More»

Genet. Mol. Res. 13(3):
2014.September.26.14
DOI:
10.4238/2014.September.26.14
Medical Genetics   Research Article

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

Authors: G.L. Shi,L. Yang,Y. Sun,Y.J. Yin and C.X. Song

Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculos.. Read More»

Genet. Mol. Res. 14(2):
http://dx.doi.org/2015.April.27.18
DOI:
http://dx.doi.org/10.4238/2015.April.27.18