Regeneration
Genetic stability of micropropagated plants of Crambe abyssinica Hochst using ISSR markers
Authors: E.T. Werner, T.C.B. Soares, A.B.P.L. Gontijo, J.D. Souza Neto and J.A.T. do Amaral
Crambe (Crambe abyssinica) is a non-edible annual herb, which was first cultivated to extract oil for industry, and now has great potential for biodiesel production. The objective of this investigation was to evaluate the genetic stability of micropropagated plants of the C. abyssinica Hochst cultivar ‘FMS brilhante’ using polymerase chain rea.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.
- DOI:
- 10.4238/2015.
The noggin2 gene of Gekko japonicus (Gekkonidae) is down-regulated in the spinal cord after tail amputation
Authors: Y. Liu, Y.L. Zhou, Y.Y. Qian, Y.J. Wang, F. Ding, X.S. Gu and M. Liu
The cDNA encoding noggin2 protein was obtained from the brain and spinal cord cDNA library of Gekko japonicus. The size of the noggin2 transcript and its expression in different tissues were analyzed by Northern blot analysis. In situ hybridization revealed positive hybridization signals in both gray and white matter of the sp.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr888
- DOI:
- 10.4238/vol9-3gmr888
Branches of NF-�ºb signaling pathway regulate hepatocyte proliferation in rat liver regeneration
Authors: C.F. Chang, W.M. Zhao, J.X. Mei, Y. Zhou, C.Y. Pan, T.T. Xu and C.S. Xu
Previous studies have demonstrated that the nuclear factor κB (NF-κB) pathway is involved in promoting cell proliferation. To further explore the regulatory branches and their sequence in the NF-κB pathway in the promotion of hepatocyte proliferation at the transcriptional level during rat liver regeneration, Rat Genome 230 2.0 array was.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.9
- DOI:
- 10.4238/2015.July.13.9
Fructus polygoni orentalis extract inhibited liver regeneration and proliferation of bone marrow cells of rat after partial hepatectomy
Authors: J.Y. Yang, J.S. Wang and H.B. Liu
To study the effect of fructus polygoni orentalis extract (EFPO) on liver regeneration and proliferation of bone marrow cells on rat model of partial hepatectomy, EFPO was extracted, and 60 adult male Wistar rats were divided randomly into 6 experimental groups. Rats were treated with intergastric administration (ig) with EFPO daily. All rats were euthani.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.13.12
- DOI:
- 10.4238/2015.July.13.12
14-3-3 Gene expression in regenerating rat liver after 2/3 partial hepatectomy
Authors: D.M. Xue, X.Q. Guo, R. Chen, Z.P. Niu and C.S. Xu
14-3-3 Proteins are a ubiquitous family of molecules that participate in protein kinase signaling pathways in all eukaryotic cells. Functioning as phosphoserine/phosphothreonine-binding modules, 14-3-3 proteins participate in the phosphorylation-dependent protein-protein interactions that control progression through the cell cycle, initiation and.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.12
- DOI:
- 10.4238/2015.March.20.12
Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells
Authors: C.F. Chang, J. Yang, W.M. Zhao, Y. Li, P.J. Guo, M.H. Li, Y. Zhou and C.S. Xu
We examined the gene expression profiles of the 5-hydroxytryptamine signaling pathway in the regenerating liver and 8 types of liver cells during rat liver regeneration, and explored expression differences in 5-hydroxytryptamine signaling pathway genes at the level of tissues and cells, as well as the role of the pathway on liver regeneration. Eight types.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.4
Three branches of phospholipase C signaling pathway promote hepatocyte growth in rat liver regeneration
Authors: G.G. Xu, Z. Geng, X.C. Zhou, Y.G. He, T.T. He, J.X. Mei,Y.J. Yang, Y.Q. Liu and C.S. Xu
In general, the phospholipase C (PLC) signaling pathway is involved in many physiological activities, including cell growth. However, little is known regarding how the PLC signaling pathway participates in regulating hepatocyte (HC) growth during liver regeneration (LR). To further explore the influence of the PLC signaling pathway on HCs at the cellular .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.29.3
- DOI:
- 10.4238/2015.May.29.3
Differential gene expression and functional analysis of pit cells from regenerating rat liver
Authors: C.S. Xu, X.G. Chen, C.F. Chang, G.P. Wang, W.B. Wang, L.X. Zhang, Q.S. Zhu and L. Wang
Hepatic pit cells are a population of large granular lymphocytes that substantially contribute to hepatic immunity. Studies have proven that pit cells have a role in liver regeneration, but the details of the relationship between pit cells and liver regeneration is not clear at present. We subjected rats to a two-third hepatectomy; pit cells with high pur.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1052
- DOI:
- 10.4238/vol10-2gmr1052
Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats
Authors: Y. Zhou, J.C. Xu and C.S. Xu
The liver has extraordinary powers of regeneration following partial hepatectomy (PH). Changes in gene expression levels play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess the time-dependent changes in.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027596
- DOI:
- 10.4238/gmr.15027596
Expression profiles of the apoptosis signaling pathway mediated by death receptor and endoplasmic reticulum in rat liver regeneration
Authors: X.K. Xing, M.H. Li, X.S. Zhu and C.S. Xu
The death receptor and endoplasmic reticulum (ER) are closely related to cell apoptosis, and it is worth studying whether the apoptosis pathways mediated by them are involved in liver regeneration. To understand the mechanism underlying death receptor- and ER-mediated apoptosis during rat liver regeneration, we used the Rat Ge.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028288
- DOI:
- 10.4238/gmr.15028288