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Replication

Microbial Genetics   Research Article

Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli

Authors: Y. Yao, Wunier and Morigen

Escherichia coli cells have dozens of two-component systems to sense and respond to various stimuli, and thereby cope with changing environments. BaeS/BaeR is one such two-component system, and it deals with a variety of envelope stresses. Interestingly, the ArcA/ArcB and TorS/TorR two-component systems are known to be associated with initiation of DNA re.. Read More»

Genet. Mol. Res. 14(4):
2015.December.14.16
DOI:
10.4238/2015.December.14.16
Human Genetics   Research Article

Ability of HMGB1 protein to bind to intrinsically bent and non-bent DNA sites in the AMPD2 gene amplicon

Authors: K.J.R. Passos, A. Fiorini, F.R. Rosado, D.V.B. Freitas, Q.A. Lima Neto, J.R. Pattaro Junior, V.P. Gaspar and M.A. Fernandez

HMGB-like proteins are architectural chromatin factors, and their function is heavily dependent on their ability to interact with DNA (especially non-canonical DNA structures). HMGB1 is involved in many DNA processes, and dysregulation of HMGB protein expression has profound effects on cellular transcription, resulting in seve.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027441
DOI:
10.4238/gmr.15027441