Rna
imDC: an ensemble learning method for imbalanced classification with miRNA data
Authors: C.Y. Wang, L.L. Hu, M.Z. Guo, X.Y. Liu and Q. Zou
Imbalances typically exist in bioinformatics and are also common in other areas. A drawback of traditional machine learning methods is the relatively little attention given to small sample classification. Thus, we developed imDC, which uses an ensemble learning concept in combination with weights and sample misclassification information to effectively cla.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.15
- DOI:
- 10.4238/2015.January.15.15
Construction and identification of recombinant adenovirus carrying human TIMP-1shRNA geneg
Authors: Y.L. Sun, H. Xie, H.L. Lin, Q. Feng and Y. Liu
The aim of this study was to construct the recombinant adenovirus carrying human TIMP-1shRNA gene expression system for preliminary identification to lay the foundation for the further study of gene therapy. Using the Adeno-XTM system, the recombinant adenovirus plasmid pAdeno-XTM green fluorescent protein (GFP)-tissue inhibitor of metalloprotease (TIMP)-.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.3
- DOI:
- 10.4238/2015.January.16.3
Microsatellite markers linked to the locus of the watermelon fruit stripe pattern
Authors: R.N.C.S. Gama, C.A.F. Santos, R.C.S. Dias, J.C.S.F. Alves and T.O. Nogueira
Agronomic performance and external and internal appearance of watermelon (Citrullus lanatus) fruit are important traits that should be taken into consideration during the development of a new cultivar, as well as being the principal identification elements used by the consumer, which are based on the external appearance and quality of the fruit. Externally, .. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.16.11
- DOI:
- 10.4238/2015.January.16.11
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells
Authors: H. Yan, J.Y. Xia and F.Z. Feng
The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019411
- DOI:
- 10.4238/gmr16019411
miRNApath: a database of miRNAs, target genes and metabolic pathways
Authors: A.O. Chiromatzo, T.Y.K. Oliveira, G. Pereira, A.Y. Costa, C.A.E. Montesco, D.E. Gras, F. Yosetake, J.B. Vilar, M. Cervato, P.R.R. Prado, R.G.C.C.L. Cardenas, R. Cerri, R.L. Borges, R.N. Lemos, S.M. Alvarenga, V.R.C. Perallis, D.G. Pinheiro, I.T. Silva, R.M. Brand�£o, M.A.V. Cunha, S. Giuliatti and W.A. Silva Jr
MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression and hence play important roles in metabolic pathways. Recent studies have evidenced the interrelation of miRNAs with cell proliferation, differentiation, development, and diseases. Since they are involved in gene regulation, they are intrinsicall.. Read More»
- Genet. Mol. Res. 6(4):
Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy
Authors: L. Ren1*, R. Zhu2* and X. Li1
Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with pote.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017798
- DOI:
- 10.4238/gmr.15017798
RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos
Authors: F. He, C.-T. Wang and L.-T. Gou
RBM22 is a newly discovered RNA-binding motif protein, belonging to the SLT11 family; it has been reported to be involved in pre-splicesome assembly and to interact with the Ca2+-signaling protein ALG-2. However, previous studies have not demonstrated whether its expression is essential for early embryogenesis in vertebrates. .. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr683
- DOI:
- 10.4238/vol8-4gmr683
RNA applications for endophytic research
Authors: J.C. Polonio, A.D. Polli, J.L. Azevedo and J.A. Pamphile
Endophytic microorganisms, mainly bacteria and fungi, have intrinsic relationships with the host plants, involving complex chemical and genetic communication networks. The relationship among these organisms involves the development of regulatory mechanisms of gene expression that control their development and response to different interactions. Although R.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038879
- DOI:
- 10.4238/gmr.15038879
Influence of suppression of CapG gene expression by siRNA on the growth and metastasis of human prostate cancer cells
Authors: B.K. Li, K. Guo, C.Y. Li, H.L. Li, P.P. Zhao,K. Chen,C.X. Liu
This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cyto.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.28
- DOI:
- 10.4238/2015.December.1.28
Differential expression of peroxisome proliferator-activated receptor �³, fatty acid synthase, and hormone-sensitive lipase in fat-tailed and thin-tailed sheep breeds
Authors: X.C. Xu, B.B. Li, X. Wei, Y.X. Yang, X.L. Wang, Y.L. Chen
Tail fat content affects meat quality, and it varies in different sheep breeds. Theoretically, lipid metabolism contributes to variation in tail fat content. Tail length, tail width, and tail girth were measured in live Tong sheep (with both short fat tail and long fat tail), Shaanbei fine wool sheep (long thin tail), Tan shee.. Read More»
- Genet. Mol. Res. 14(4):