Rna
Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells
Authors: H. Zhang, F. Chen, G.L. Li, Y.Y. Ding, Z.R. Tao, J.J. Li,S.L. Zhong and L.Z. Lu
Estrogen regulates reproductive behavior and drives the proliferation and differentiation of several cell types. These physiological functions of estrogen are mediated by estrogen receptors (ERs), and each ER isoform plays a distinct role. To clarify the molecular mechanism of estrogen action and to evaluate the effect of ERs .. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.17.20
- DOI:
- http://dx.doi.org/10.4238/2014.March.17.20
Circulatory microRNA-145 expression is increased in cerebral ischemia
Authors: C.S. Gan, C.W. Wang and K.S. Tan
Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression .. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.27.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.27.1
Genetic algorithm-based efficient feature selection for classification of pre-miRNAs
Authors: P. Xuan, M.Z. Guo, J. Wang, C.Y. Wang, X.Y. Liu and Y. Liu
In order to classify the real/pseudo human precursor microRNA (pre-miRNAs) hairpins with ab initio methods, numerous features are extracted from the primary sequence and second structure of pre-miRNAs. However, they include some redundant and useless features. It is essential to select the most representative feature subset; t.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr969
- DOI:
- 10.4238/vol10-2gmr969
microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL
Authors: X.J. Lai, X.Y. Cheng and L.D. Hu
Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048853
- DOI:
- 10.4238/gmr15048853
Prediction of disease-related microRNAs by incorporating functional similarity and common association information
Authors: K. Han, P. Xuan2, J. Ding, Z.J. Zhao, L. Hui and Y.L. Zhong
The identification of human disease-related microRNAs (miRNAs) is important for understanding the pathogenesis of diseases, but to do this experimentally is a costly and time-consuming process. Computational prediction of disease-related miRNA candidates is a valuable complement to experimental studies. It is essential to deve.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.5
- DOI:
- 10.4238/2014.March.24.5
Gene expression characteristics of growth-inhibited rice seedlings induced by low-energy N+-beam implantation
Authors: H. Ya, Q. Chen, W. Wang and Y. Cheng
Using the RNA sequencing, transcriptomes of growth-inhibited rice seedlings induced by low-energy N+-beam implantation were analyzed. The results showed that rice genes related to binding, electron carrier activity, transcription factor, auxin signal transduction, photosynthesis, and oxidoreductase activity were involved in th.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.9
- DOI:
- 10.4238/2014.August.15.9
Prediction and extraction of microRNA2target interactions associated with leukemia
Authors: L. Gong, Q. Yan, R. Yang and X. Sun
MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of diseases. To understand microRNAs’ function, it is vital to identify microRNA2target interactions. This work explores the prediction and extracti.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.19
- DOI:
- 10.4238/2014.March.24.19
Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis
Authors: Y.P. Gu, Q.Y. Yuan, H. Zhang, C.J. Wang and F. Zhou
Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.4
- DOI:
- 10.4238/2015.July.28.4
Integrated miRNA-mRNA analysis of Epstein-Barr virus-positive nasopharyngeal carcinoma
Authors: L.H. Zhu, X.T. Miao and N.Y. Wang
This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. Th.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.20
- DOI:
- 10.4238/2015.June.1.20
Polymorphisms in different EST-SSR types derived from the Chinese bayberry (Myrica rubra, Myricaceae) transcriptome
Authors: S.Y. Zhang, C. Feng, C.J. Xu, C.Q. Zhu and K.S. Chen
Most plant expressed sequence tag-simple sequence repeats (EST-SSRs) are not polymorphic, and it is important to learn the characteristics of highly polymorphic EST-SSRs. In this study, 357 compound and 5557 non-compound EST-SSRs, identified from the transcriptome of the Chinese bayberry (Myrica rubra ‘Biqi’), were divided into 11 types based .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.21
- DOI:
- 10.4238/2015.June.1.21