Rna
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1
Authors: Y.Q. Wang, Y. Cai and X.M. Zhong
Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regula.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039256
- DOI:
- 10.4238/gmr16039256
Characterization and phylogenetic affiliation of Actinobacteria from tropical soils with potential uses for agro-industrial processes
Authors: J.C.M. Dornelas, J.E.F. Figueiredo, C.S. de Abreu, U.G.P. Lana, C.A. Oliveira and I.E. Marriel
Secondary metabolites produced by Actinobacteria of tropical soils represent a largely understudied source of novel molecules with relevant application in medicine, pharmaceutical and food industries, agriculture, and environmental bioremediation. The present study aimed to characterize sixty-nine Actinobacteria isolated from .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039703
- DOI:
- 10.4238/gmr16039703
ITS2 as a molecular marker for the identification of Diatraea saccharalis and D. flavipennella and possible infection with Cotesia spp
Authors: M.S. Regueira Neto, R.P. Barros, M.A.J. Morais, V.Q. Balbino and V. Loreto
In Brazil, the species Diatraea flavipennella and D. saccharalis play an important role in the sugar and alcohol agribusiness by causing many damages in sugarcane fields. The egg, larva, pupa, and adult stages are very morphologically similar between these species, and the identification can be confused. The internal transcribed spacer 2 (ITS 2) from ribo.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039732
- DOI:
- 10.4238/gmr16039732
MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2
Authors: T. Zhang, J.G. Wan, J.B. Liu and M. Deng
The forkhead box F2 (Foxf2) gene suppresses epithelial-mesenchymal transition via the modulation of transcription of zinc finger E-box-binding homeobox 1 (Zeb1) and epithelial (E)-cadherin, thereby inhibiting tumor metastasis. Additionally, the specific binding of microRNA (miR)-200c to Foxf2 mRNA impedes metastatic pulmonary .. Read More»
- Genet. Mol. Res. 16(3):
- gmr16038971
- DOI:
- 10.4238/gmr16038971
Bayesian analyses of genetic parameters for growth traits in Nellore cattle raised on pasture
Authors: F.B. Lopes, J.L. Ferreira, R.B. Lobo and G.J.M. Rosa
This study was carried out to investigate (co)variance components and genetic parameters for growth traits in beef cattle using a multi-trait model by Bayesian methods. Genetic and residual (co)variances and parameters were estimated for weights at standard ages of 120 (W120), 210 (W210), 365 (W365), and 450 days (W450), and f.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039606
- DOI:
- 10.4238/gmr16039606
De novo transcriptome assembly of sugarcane leaves submitted to prolonged water-deficit stress
Authors: A.A. Belesini, F.M.S. Carvalho, B.R. Telles, G.M. de Castro, P.F. Giachetto, J.S. Vantini, S.D. Carlin, J.O. Cazetta, D.G. Pinheiro and M.I.T. Ferro
Sugarcane production is strongly influenced by drought, which is a limiting factor for agricultural productivity in the world. In this study, the gene expression profiles obtained by de novo assembly of the leaf transcriptome of two sugarcane cultivars that differ in their physiological response to water deficit were evaluated.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16028845
- DOI:
- 10.4238/gmr16028845
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
ERCC1 mRNA expression is associated with the clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy
Authors: H. Zhang1, J. Li2, Y. Zhang2, M. Sun3, P. Zhao1, G. Zhang2, C. Jin2, L. Sun1, M. He1, B. Wang2 and X. Zhang2
We conducted a prospective study to analyze the expression of the excision repair cross-complementing group 1 (ERCC1) and ribonucleotide reductase subunit M1 (RRM1) genes in 297 Chinese patients with advanced non-small cell lung cancer (NSCLC). The goal of this study was to evaluate these genes as potential biomarkers for prediction of tumor response and .. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.4.16
- DOI:
- 10.4238/2014.December.4.16
Bioinformatic analysis of miRNA expression patterns in TFF2 knock-out mice
Authors: Y. Yin, H.Q. Shan, W. Huang, Y.M. Wu, H. Lu and Y. Jin
Trefoil factors, which bear a unique 3-loop trefoil domain, are a family of small secretory protease-resistant peptides (7-12 kDa) discovered in the 1980s. Trefoil factor 2 (TFF2) is a unique member of trefoil factors family that plays important roles in gastrointestinal mucosal defense and repair. However, few studies have characterized the miRNA express.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.26
- DOI:
- 10.4238/2014.October.20.26
Prediction of potential novel microRNAs in soybean when in symbiosis
Authors: G.A. Barros-Carvalho1,2, A.R. Paschoal3, F.C. Marcelino-Guimar�£es1 and M. Hungria1
MicroRNAs (miRNAs) are small molecules, noncoding proteins that are involved in many biological processes, especially in plants; among these processes is nodulation in the legume. Biological nitrogen fixation is a key process, with critical importance to the soybean crop. This study aimed to identify the potential of novel miRNAs to act during the root no.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.28
- DOI:
- 10.4238/2014.October.20.28