Rna
S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation
Authors: Y.J. Sun, X.K. Wang and B.J. Li
We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.4
- DOI:
- 10.4238/2015.August.10.4
Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 inpig adipose tissue
Authors: R.L. Qi, Y. Chen, J.X. Huang andF.Y. Yang
In this study, we evaluated the effect and possible mechanism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were collected, and real-time polymer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.7
- DOI:
- 10.4238/2015.June.26.7
Expression of glutamine synthetase in Tegillarca granosa (Bivalvia, Arcidae) hemocytes stimulated by Vibrio parahaemolyticus and lipopolysaccharides
Authors: Y.B. Bao, L. Li, M.X. Ye, Y.H. Dong, W.X. Jin and Z.H. Lin
The blood cockle, Tegillarca granosa, is a widely consumed clam in the Indo-Pacific region. Glutamine synthetase (GS) is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. We identified the GS of T. granosa (Tg-GS) from hemocytes by 3'- and 5'-rapid amplification .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.9
- DOI:
- 10.4238/2013.April.10.9
Comparative analysis of the liver tissue transcriptomes of Mongolian and Lanzhou fat-tailed sheep
Authors: X. Cheng, S.G. Zhao, Y. Yue, Z. Liu, H.W. Li and J.P. Wu
Research on gene regulation has been made possible with the help of RNA sequencing applications such as RNA-Seq technology for high-throughput sequencing platforms. Recent studies have explored the transcriptomes from different tissues of domestic animals using RNA-Seq technology, but little research has been done to study the.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028572
- DOI:
- 10.4238/gmr.15028572
Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients
Authors: B. Qi, S.G. Liu, X.G. Qin, W.J. Yao, J.G. Lu, L. Guo, T.Y. Wang, H.C. Li and B.S. Zhao
There have been few reports evaluating the expression and function of the microRNA miR-212 in esophageal cancer. The aim of this study was to investigate the relationship between miR-212 expression and clinicopathological factors and prognoses of esophageal cancer. MicroRNA was extracted from 46 esophageal cancer patients usin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.18
- DOI:
- 10.4238/2014.September.26.18
miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2
Authors: P. Wang, H.Y. Lv, D.M. Zhou and E.N. Zhang
Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, mi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026415
- DOI:
- 10.4238/gmr.15026415
Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats
Authors: W.M. Wang, Z. Liu and G. Chen
As the most common cardiac disease, myocardial infarction is followed by hypertrophy of cardiac myocytes and reconstruction of ventricular structure. The up-regulation of a series of factors including metalloproteinases, inflammatory factors, and growth factors after primary infarction lead to the hypertrophy, apoptosis, necro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027338
- DOI:
- 10.4238/gmr.15027338
Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A
Authors: Z. Ni, X.F. Shang, Y.F. Wang, Y.J. Sun and D.J. Fu
MicroRNAs (miRs) are associated with tumor progression in various cancers, such as gastric and hepatic carcinomas, and lung cancer. miR-301a is overexpressed and displays oncogenic activity in cancers. We investigated the biological involvement of miR-301a in osteosarcoma (OS). Quantitative real-time polymerase chain reaction .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027807
- DOI:
- 10.4238/gmr.15027807
Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis
Authors: M. Zhang, L.J. Zhao, W.Q. Liang and Z.P. Mao
Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.3
- DOI:
- 10.4238/2015.December.11.3
Decreased microRNA-198 expression and its prognostic significance in human glioma
Authors: H.B. Man, W.P. Bi and H.H. Man
Previous evidence has shown the association of aberrant miR-198 expression with tumorigenesis and progression of many human malignancies. However, its involvement in human glioma is still unclear. Therefore, the aim of the current study was to investigate the expression and function of miR-198 in human gliomas. Using real-time.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027656
- DOI:
- 10.4238/gmr.15027656