Rna
Transcriptome analysis and de novo annotation of the critically endangered Amur sturgeon (Acipenser schrenckii)
Authors: X.J. Zhang, H.Y. Jiang, L.M. Li, L.H. Yuan and J.P. Chen
The aim of this study was to provide comprehensive insights into the genetic background of sturgeon by transcriptome study. We performed a de novo assembly of the Amur sturgeon Acipenser schrenckii transcriptome using Illumina Hiseq 2000 sequencing. A total of 148,817 non-redundant unigenes with base length of approximately 12.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027999
- DOI:
- 10.4238/gmr.15027999
Mitochondrial transfer RNA mutations and hypertension
Authors: S.L. Yin, C. Lan, H. Pei, and Z.Q. Zhu
Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.42
- DOI:
- 10.4238/2015.December.21.42
Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less
Authors: D.C. Casagrande, J.C.L. Ribalta, K.D.P.F. Leite, M. Schimidt and N.M.D.G. Speck
We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017916
- DOI:
- 10.4238/gmr.15017916
PKR and HMGB1 expression and function in rheumatoid arthritis
Authors: W.J. Wang, S.J. Yin and R.Q. Rong
The pathogenesis of rheumatoid arthritis (RA) is characterized by inflammation. We aimed to examine the roles of double-stranded RNA-activated protein kinase (PKR) and high-mobility group box chromosomal protein 1 (HMGB1) in a rat model of RA. Male SD rats were divided into three groups: control, RA model, and intervention (RA model plus treatment). The m.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.11
- DOI:
- 10.4238/2015.December.22.11
miR-125a-5p expression is associated with the age of breast cancer patients
Authors: H. He, F. Xu, W. Huang, S.Y. Luo, Y.T. Lin, G.H. Zhang, Q. Du and R.H. Duan
Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.17
- DOI:
- 10.4238/2015.December.22.17
Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis
Authors: M.L. Zhi, Z.J. Liu, X.Y. Yi, L.J. Zhang and Y.X. Bao
Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.28
- DOI:
- 10.4238/2015.December.22.28
Phylogenetic relationships of leaf monkeys (Presbytis; Colobinae) based on cytochrome b and 12S rRNA genes
Authors: V.F. Vun, M.C. Mahani, M. Lakim, A. Ampeng and B.M. Md-Zain
Little is known about the classification and phylogenetic relationships of the leaf monkeys (Presbytis). We analyzed mitochondrial DNA sequences of cytochrome b (Cyt b) and 12S rRNA to determine the phylogenetic relationships of the genus Presbytis. Gene fragments of 388 and 371 bp of Cyt b and 12S rRNA, respectively, were seq.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1048
- DOI:
- 10.4238/vol10-1gmr1048
Effective sample selection for classification of pre-miRNAs
Authors: K. Han
To solve the class imbalance problem in the classification of pre-miRNAs with the ab initio method, we developed a novel sample selection method according to the characteristics of pre-miRNAs. Real/pseudo pre-miRNAs are clustered based on their stem similarity and their distribution in high dimensional sample space, respective.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1054
- DOI:
- 10.4238/vol10-1gmr1054
Increased CD56+ NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion
Authors: Y. Gao and P.L. Wang
Recurrent spontaneous abortion (RSA) is reported to be associated with immune imbalance at the maternal-fetal interface. Immune cells in the decidual tissue are involved in maintaining immune tolerance during pregnancy; however, whether natural killer (NK) and T cells are altered in unexplained RSA (URSA) remains unknown. In this study, we compared the nu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.36
- DOI:
- 10.4238/2015.December.22.36
Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer
Authors: Y.B. Ma, G.X. Li, J.X. Hu, X. Liu and B.M. Shi
MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase cha.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.2
- DOI:
- 10.4238/2015.December.23.2