Rna
Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2
Authors: X.M. Tian, Y.Z. Luo, P. He, J. Li, Z.W. Ma and Y. An
Prostate cancer is a common malignancy of the male reproductive-urinary system. MDM2 is an oncogene, whose expression can be regulated by microRNA (miRNA). The present study investigated the expression and correlation of miRNA-509-5p and MDM2 to determine the mechanism of their function in invasion and migration of prostate ca.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019195
- DOI:
- 10.4238/gmr16019195
MicroRNA expression profile of a Malaysian Bajau family with familial mitochondrial neurogastrointestinal encephalomyopathy
Authors: F.L. Yong, C.W. Wang and K.S. Tan
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare, autosomal recessive disorder associated with mutations in the thymidine phosphorylase (TYMP) gene. The main objective of this study was to characterize the genetic profiles of the deceased proband’s family members (N = 4) using DNA sequencing and to determine miRNA deregulation.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.13
- DOI:
- 10.4238/2015.October.26.13
MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice
Authors: L. Song, Z.R. Zhang, J.L. Zhang, X.B. Zhu, L. He, Z. Shi, L. Gao, Y. Li, B. Hu and F.M. Feng
Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.22
- DOI:
- 10.4238/2015.October.26.22
Microbial diversity in raw milk and traditional fermented dairy products (Hurood cheese and Jueke) from Inner Mongolia, China
Authors: M.L. Gao, H.M. Hou, X.X. Teng, Y.L. Zhu, H.S. Hao and G.L. Zhang
Hurood cheese (HC) and Jueke (Jk) are 2 traditional fermented dairy products produced from raw milk (RM) in the Inner Mongolia region of China. They have a long history of production and consumption. The microbial compositions of RM, HC, and Jk vary greatly, and are influenced by their geographical origins and unique processin.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019451
- DOI:
- 10.4238/gmr16019451
Single cell transcriptome profiling revealed differences in gene expression during oocyte maturation in Haimen white goats
Authors: X.Y. Yin, G.H. Cheng, H.Y. Guo, Q. Wang, Y.J. Li and H. Zhang
Juvenile in vitro embryo transfer is an important animal reproductive technology that can shorten the generation interval of livestock, explore the reproductive potential of dams with excellent genetic traits, accelerate genetic progress and production efficiency of the herd, and provide a wealth of genetic resources for lives.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019564
- DOI:
- 10.4238/gmr16019564
Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase
Authors: Y.-J. Shi K.-K. Huo
Anaphase-promoting complex/cyclosome (APC/C) is a key E3 ubiquitin ligase in cell division, which catalyses ubiquitination of cell-cycle regulators. Studying this complex could reveal important information regarding its application in cancer research and therapy. In this study, 4 synthesized small interfering RNAs (siRNAs) were transfected into HEK293T ce.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.24.6
- DOI:
- 10.4238/2012.August.24.6
Cloning and sequencing of the rDNA gene family of the water buffalo (Bubalus bubalis)
Authors: C.Y. Pang T.X. Deng D.S. Tang C.Y. Yang H. Jiang B.Z. Yang X.W. Liang
The rDNA genes coding for ribosomal RNA in animals are complicated repeat sequences with high GC content. We amplified water buffalo rDNA gene sequences with the long and accurate (LA) PCR method, using LA Taq DNA polymerase and GC buffer, based on bioinformatic analysis of related organisms. The rDNA genes were found to consist of 9016 nucleotides, inclu.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.3
- DOI:
- 10.4238/2012.July.10.3
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells
Authors: L. Zhang, H.E.X.D. Niyazi, H.R. Zhao, X.P. Cao, M.N.S. Abudula, W.J. Ye, S.A. Zhang, R.H.M. Yiming, Y. Zhang, W.P. Su, R. Chen, Y. Ouyang, N. Miao and Y.X. Bao
Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyze.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019269
- DOI:
- 10.4238/gmr16019269
Increased expression of a novel splice variant of the complement component 4 (C4A) gene in mastitis-infected dairy cattle
Authors: Y. Yang J.M. Huang Z.H. Ju Q.L. Li L. Zhou R.L. Li J.B. Li F.X. Shi J.F. Zhong C.F. Wang
The complement system helps in the direct lysis of invading pathogens and modulates phagocytic, humoral and cellular immune responses. Complement 4 is a critical component in complement activity and protection against many bacterial pathogens because it is essential to classical and lectin activation pathways. We used reverse transcription and PCR to investi.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.12
- DOI:
- 10.4238/2012.May.18.12
Characterization and bacterial-binding activity of a novel C-type lectin from the red-spotted grouper, Epinephelus akaara
Authors: Z.W. Zhang X.F. Shi M. Qu S.X. Ding
Because of their specific binding to carbohydrates, lectins play a crucial role in pathogen recognition and clearance in vertebrate animals. Previously, only two types of collectins had been isolated from bony fish: mannan-binding lectin (MBL) and galactose-binding lectin (GalBL). We sequenced a novel collectin (designated EALec1) from the red-spotted gro.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.11.1
- DOI:
- 10.4238/2012.May.11.1