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Sequence variation in the Toxoplasma gondii ROP20 gene among strains from different hosts and geographical locations
Authors: H.R. Ning, J.L.Wang, S.Y. Qin, S.Y. Huang, Z.L. Lou, L.Y. Hu and X.Q. Zhu
Toxoplasma gondii, an opportunistic protozoan parasite, infects almost all warm-blooded animals. In this study, we examined the sequence variation in rhoptry protein 20 (ROP20) genes among 18 T. gondii isolates collected from different hosts and geographical regions. Full length ROP20 genes were amplified and sequenced. The results showed that the genes w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.8
- DOI:
- 10.4238/2015.July.28.8
Effects of the antipsoriatic drug dithranol on E2A and caspase-9 gene expression in vitro
Authors: C. Ronpirin and T. Tencomnao
Although the precise causes of psoriasis remain to be elucidated, psoriasis has been known as a disorder in which factors in the immune system, enzymes and other biochemical substances that regulate skin cell division are functionally imbalanced, thereby resulting in rapid proliferation of keratinocytes and incomplete keratini.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.17.3
- DOI:
- 10.4238/2012.February.17.3
Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy
Authors: X.-L. Xu, Y.-L. Yao, W.-Z. Xu, J.-G. Feng and W.-M. Mao
Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with respo.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.16
Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis
Authors: M. Xiao, T. Wang, T. Zhu and F. Wen
Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.1
Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population
Authors: Q. Chen, W.J. Li, Y.Y. Wan, C.D. Yu and W.G. Li
The etiology of gallstone disease is multifactorial; supersaturation of bile with cholesterol is a primary cause for gallstone formation. In previous studies, we found that fibroblast growth factor receptor 4 (FGFR4) plays an important role in maintaining bile acid homeostasis by regulating the expression of cholesterol 7&alph.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.8.3
- DOI:
- 10.4238/2012.March.8.3
Effect of leukocyte filtration on the P-selectin expression of apheresis platelets
Authors: Z.T. Xie, C. Chen, S.H. Zhang, H.M. Yang and Z.H. Tao
The aim of this study was to investigate the effect of leukocyte filtration on the P-selectin (CD62P) surface expression of apheresis platelets during the retention period. Ten bags of apheresis platelets stored for 1 day (0-24 h) and 10 bags of apheresis platelets stored for 2 days (24-48 h) were used for leukocyte filtration (experimental group). Ten ba.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.15
- DOI:
- 10.4238/2015.June.1.15
DNA barcoding of Oryx leucoryx using the mitochondrial cytochrome C oxidase gene
Authors: K. Elmeer, A. Almalki, K.A. Mohran, K.N. AL-Qahtani and M. Almarri
The massive destruction and deterioration of the habitat of Oryx leucoryx and illegal hunting have decimated Oryx populations significantly, and now these animals are almost extinct in the wild. Molecular analyses can significantly contribute to captive breeding and reintroduction strategies for the conservation of this endang.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.8.2
- DOI:
- 10.4238/2012.March.8.2
Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility
Authors: Z.-Q. Li, X.-P. Hu, , J.-Y. Zhou, X.-D. Xie and J.-M. Zhang
We investigated the role of 7 single nucleotide polymorphisms in the carbonic anhydrase (CA) VI gene (rs2274328, rs17032907, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186) and the possible association between these polymorphisms and dental caries susceptibility in a Northwestern Chinese population. We collected samples from 164 high caries e.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.16
- DOI:
- 10.4238/2015.June.1.16
IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease
Authors: L. Li, E. Li, L.H. Zhang, L.G. Jian, H.P. Liu and T. Wang
We conducted this case-control study to investigate the genetic role of IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T in the development of coronary artery disease (CAD) in a Chinese population. Polymorphisms IL-1β+3954C/T, IL-6-174G/C, IL-6-572C/G, IL-10-1082A/G, and IL-10-819C/T were determined by polymerase chain re.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.12
- DOI:
- 10.4238/2015.July.28.12
Proapoptotic effects of heme oxygenase-1 inhibitor on Kasumi-1 cells via the ATF4/ CHOP/Ire-1�± pathway
Authors: S.-X. Wei, Y.-T. Wang, Q.-X. Chai, Q. Fang, Y.-M. Zhang and J.-S. Wang
We evaluated the effects of down-regulated heme oxygenase (HO)-1 expression on the proliferation of the acute myelocytic leukemia Kasumi-1 cell line by using the HO-1 inhibitor zinc protoporphyrin IX (ZnPPIX) in combination with daunorubicin (DNR), and evaluated the mechanism. The proliferation rates of cells treated with 10 mg/mL DNR and 10 mM ZnPPIX ind.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.17
- DOI:
- 10.4238/2015.June.1.17