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EZH2 suppresses hepatocellular differentiation of mouse bone marrow mesenchymal stem cells
Authors: T. Lu, H. Sun, J. Lv, M.F. Yang, F. Zhang, Y. Qian, and X.J. Dong
Our previous studies have indicated that mouse bone marrow mesenchymal stem cells (mBMMSCs) have potential to differentiate into hepatocytes with high efficiency. Our study aimed to evaluate the role of the mouse histone methyltransferase enhancer of zeste homolog 2 gene (EZH2) in the hepatocellular differentiation of mBMMSCs... Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.31.3
- DOI:
- 10.4238/2014.March.31.3
High segregation distortion in maize B73 x teosinte crosses
Authors: G. Wang, Q.Q. He, Z.K. Xu and R.T. Song
Two genetic linkage maps of cultivated maize inbred lines and teosinte species were constructed. One population comprised 81 F2 individuals derived from a cross between maize inbred line B73 and Zea mays ssp parviglumis, while the second consisted of 63 backcross individuals from a cross of maize inbred line B73 with Z. mays s.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.19.3
- DOI:
- 10.4238/2012.March.19.3
MRJP microsatellite markers in Africanized Apis mellifera colonies selected on the basis of royal jelly production
Authors: R.S. Parpinelli, M.C.C. Ruvolo-Takasusuki and V.A.A. Toledo
It is important to select the best honeybees that produce royal jelly to identify important molecular markers, such as major royal jelly proteins (MRJPs), and hence contribute to the development of new breeding strategies to improve the production of this substance. Therefore, this study focused on evaluating the genetic varia.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.16
- DOI:
- 10.4238/2014.August.28.16
Association of serum adipose triglyceride lipase levels with obesity and diabetes
Authors: L. Yang, S.J. Chen, G.Y. Yuan, L.B. Zhou, D. Wang, X.Z. Wang and J.J. Chen
The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were di.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.18
- DOI:
- 10.4238/2014.August.28.18
Pedigree analysis of Mexican families with Fabry disease as a powerful tool for identification of heterozygous females
Authors: B.E. Guti�©rrez-Amavizca, R. Orozco-Castellanos, J. R. Padilla-Guti�©rrez, Y. Valle and L.E. Figuera
Fabry disease (FD) is an X-linked lysosomal storage disease caused by α-galactosidase A deficiency; in contrast to other X-linked diseases, heterozygous females can be as affected as men. The construction and analysis of a family pedigree is a powerful tool to aid clinicians in diagnosis, establishment of inheritance pat.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.19
- DOI:
- 10.4238/2014.August.28.19
Genetic variability for iron and zinc content in common bean lines and interaction with water availability
Authors: H.S. Pereira, M.J. Del Peloso, P.Z. Bassinello, C.M. Guimar�£es, L.C. Melo and L.C. Faria
The common bean is an important source of iron and zinc in humans. Increases in the contents of these minerals can combat mineral deficiencies, but these contents are influenced by environmental conditions. Thus, the objectives of this study were to investigate the interaction between common bean lines and water availability o.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.21
- DOI:
- 10.4238/2014.August.28.21
Mutation analyses and prenatal diagnosis in families of X-linked severe combined immunodeficiency caused by IL2Rg gene novel mutation
Authors: Q.L. Bai, N. Liu, X.D. Kong, X.J. Xu and Z.H. Zhao
We investigated the feasibility of interleukin-2 receptor gamma (IL2Rg) gene based on gene mutation analysis and prenatal diagnosis of X-linked severe combined immunodeficiency (XSCID). Blood samples of patients and their parents of X-SCID (family 1) and X-SCID (family 2) were collected. IL2Rg gene sequences of the 2 families were analyzed using bi-direct.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.2
- DOI:
- 10.4238/2015.June.9.2
De novo assembly and characterization of the root transcriptome and development of simple sequence repeat markers in Paphiopedilum concolor
Authors: D.M. Li, C.Y. Zhao, X.R. Liu, X.F. Liu, Y.J. Lin, J.W. Liu, H.M. Chen and F.B. LÃ?Â?
Paphiopedilum orchids (Orchidaceae) have attracted much attention from botanists and horticulturists because of their peculiar leaves and beautiful flowers. Furthermore, the dry roots of Paphiopedilum plants have well-known medicinal uses. However, it is unknown how sensitive and plastic the root genes are to environmental changes or how these environment.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.5
- DOI:
- 10.4238/2015.June.9.5
Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin
Authors: Y. Yu, W.N. Wang, H.Z. Han, K.L. Xie, G.L. Wang and Y.H. Yu
We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2 , LPS, LPS+H2 , H2 , and LPS+H2 in saturated hydrogen-ri.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.9.6
- DOI:
- 10.4238/2015.June.9.6
Analysis of genetic diversity of a native population of Myrcia lundiana Kiaersk. plants using ISSR markers
Authors: M.F. Alves, D.A.C. Nizio, F.A. Brito, T.S. Sampaio, A.V.C. Silva, M.F. Arrigoni-Blank, S.V.A. Carvalho and A.F. Blank
Myrcia lundiana Kiaersk. is a tree of the family Myrtaceae found in tropical and subtropical areas of the southern hemisphere that produces essential oil. The aim of this study was to characterize the genetic diversity of M. lundiana plants from a native population of Parque Nacional de Itabaiana, using inter-simple sequence r.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049198
- DOI:
- 10.4238/gmr15049198