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Effect of ARMS2 gene polymorphism on intravitreal ranibizumab treatment for neovascular age-related macular degeneration
Authors: H. Bardak, Y. Bardak, Y. Ercalik, E. Turkseven Kumral, S. Imamoglu, M. Gunay, H. Ozbas and O. Bagci
Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries. The ARMS2 gene has been found to be associated with AMD. Currently, intravitreal ranibizumab (IVR) treatment is one of the widely used treatments for neovascular AMD. The aim of this study was to investigate the association between t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049164
- DOI:
- 10.4238/gmr15049164
Differential expression of Toll-like receptors in goat dominant and nondominant follicles
Authors: G.X. E, Y.J. Zhao, Y.H. Ma, M.X. Chu, Q.H. Hong, S.J. Lv, L. Zhu, F.K. Li, Y.G. Han, X. Wu5and Y.F. Huang
The mechanism of dominant follicle selection is unclear because of its physiological complexity. However, some studies have reported that the immune system plays an important role in reproductive physiology. The objective of the current study was to investigate the differential expression of Toll-like receptors (TLRs) in the d.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049157
- DOI:
- 10.4238/gmr15049157
Evaluation of crosses of Holstein, Jersey or Brown Swiss sires x Holstein-Friesian/Gir dams. 3. Lifetime performance and economic evaluation
Authors: R.L. Teodoro and F.E. Madalena
Lifetime dairy production, reproduction and growth traits of 75 females sired by Holstein, Jersey or Brown Swiss bulls and Holstein- Friesian x Gir dams of 1/2 to 3/4 Holstein-Friesian fractions were compared. The animals were in a single herd under the same management. Milk, fat and protein yields, concentrates fed, reproduct.. Read More»
- Genet. Mol. Res. 4(1):
Evidence for a natural hybrid of peacock bass (Cichla monoculus vs Cichla temensis) based on esterase electrophoretic patterns
Authors: Aylton Saturnino Teixeira and Suzana da Silva de Oliveira
Esterase (Est) and esterase-D (Est-D) electrophoretic patterns identified by starch gel electrophoresis of skeletal muscle protein extracts of 184 specimens of three species of peacock bass, locally known as tucunarés (Cichla monoculus, C. temensis and Cichla sp), plus four specimens of a supposed hybrid (C. monoculus v.. Read More»
- Genet. Mol. Res. 4(1):
Specific and straightforward molecular investigation of �²-thalassemia mutations in the Malaysian Malays and Chinese using direct TaqMan genotyping assays
Authors: S.L. Kho, K.H. Chua, E. George and J.A.M.A. Tan
Beta-thalassemia is a life-threatening inherited blood disorder. Rapid characterization of β-globin gene mutations is necessary because of the high frequency of Malaysian β-thalassemia carriers. A combination real-time polymerase chain reaction genotyping assay using TaqMan probes was developed to confirm β-globin gene mutations. In this st.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.4
- DOI:
- 10.4238/2013.February.28.4
Hereditary hemochromatosis in a Brazilian university hospital in S�£o Paulo State (1990-2000)
Authors: Ana L.C. Martinelli, Rui Filho, Samantha Cruz, Rendrik Franco,Marli Tavella, Marie Secaf, Leandra Ramalho, Sergio Zucoloto, Sandra Rodrigues and Marcos Zago
Hereditary hemochromatosis (HH) is the most common genetic disease among individuals of European descent. Two mutations (845G→A, C282Y and 187C→G, H63D) in the hemochromatosis gene (HFE gene) are associated with HH. About 85-90% of patients of northern European descent with HH are C282Y homozygous. The prevalence of .. Read More»
- Genet. Mol. Res. 4(1):
Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population
Authors: T. Meng, Q. Ren, J.M. Wang, H. Shi, S.T. Zhang and M.T. Liu
Intervertebral disc disease is a multifactorial condition, yet disease pathogenesis that can be promoted by a single dominant mutation affecting the expression of susceptibility genes. We performed a case-control study to assess the influence of the COL9A2 Gln326Arg polymorphism on risk of intervertebral disc disease in a Chin.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048958
- DOI:
- 10.4238/gmr15048958
No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population
Authors: T. Tencomnao, V. Thongrakard, W. Phuchana, T. Sritharathikhun and S. Suttirat
Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major dep.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr823
- DOI:
- 10.4238/vol9-2gmr823
Molecular cloning and characterization of the glyceraldehyde-3-phosphate dehydrogenase gene from Penicillium expansum PE-12
Authors: T. Zhang, Z. Qi, Q.S. Yu and K.X. Tang
Penicillium expansum produces large amounts of lipase, which is widely used in laundry detergent and leather industry. We isolated the glyceraldehyde-3-phosphate dehydrogenase gene (PeGPD) from P. expansum PE-12 through reverse transcriptase PCR and 5êÃ?Â?Ã?Â?-3êÃ?Â?Ã?Â?-rapid amplification of cDNA ends (RACE-PCR). The gene is 1266 bp long, in.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.6.2
- DOI:
- 10.4238/2013.February.6.2
Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma
Authors: X. Ning, X.W. Shang, Y. Zhuang, M. Liu, H. Yang, H. Zhang and M.Z. Huang
Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 l.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048876
- DOI:
- 10.4238/gmr15048876