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Comparison of the antiplatelet effect of clopidogrel benzene sulfonate and clopidogrel hydrogen sulfate in stable coronary heart disease
Authors: S.H. Wang, X. Li, F.L. Hou, Y.J. Tian, Y.H. Liu and S.L. Zheng
Clopidogrel hydrogen sulfate (CHS) is a thienopyridine, which can be used to prevent cardiovascular complications alone or in combination with acetyl salicylic acid as an important antiplatelet agent. Clopidogrel benzene sulfonate (CB) is a special clopidogrel salt that can be used as a conventional drug for antiplatelet effec.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027136
- DOI:
- 10.4238/gmr.15027136
Transcriptome expression profiling of fur color formation in domestic rabbits using Solexa sequencing
Authors: L.Z. Qin, W.Z. Wang, L.J. Shi, X.Y. Wan, X.R. Yan, Q.Q. Weng and X.S. Wu
Fur color is an important, genetically determined characteristic of domestic rabbits, and rabbit furs are of great economic value. To investigate the molecular genetics associated with fur color determination in domestic rabbits, we used Solexa-sequencing technology to probe gene expression in dorsal skin tissues sampled from .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027413
- DOI:
- 10.4238/gmr.15027413
Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglycerides in elderly men
Authors: L.M.Q. Ara�ºjo, M.S. Cendoroglo, C.O. Gigek, E.S. Chen and M. de A.C. Smith
Lipoprotein lipase is essential for triglyceride hydrolysis. The polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and tri.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr689
- DOI:
- 10.4238/vol9-1gmr689
DNA repair mutant pso2 of Saccharomyces cerevisiae is sensitive to intracellular acetaldehyde accumulated by disulfiram-mediated inhibition of acetaldehyde dehydrogenase
Authors: M. Brendel, G. Marisco, I. Ganda, R. Wolter and C. Pungartnik
Blocking aldehyde dehydrogenase with the drug disulfiram leads to an accumulation of intracellular acetaldehyde, which negatively affects the viability of the yeast Saccharomyces cerevisiae. Mutants of the yeast gene PSO2, which encodes a protein specific for repair of DNA interstrand cross-links, showed higher sensitivity to .. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr695
- DOI:
- 10.4238/vol9-1gmr695
Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer
Authors: X. Chen, X.S. Liu, H.Y. Liu, Y.Y. Lu and Y. Li
Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027702
- DOI:
- 10.4238/gmr.15027702
Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients
Authors: M. Taheri, F. Mahjoubi and R. Omranipour
One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports ma.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr669
- DOI:
- 10.4238/vol9-1gmr669
Effect of polychlorinated biphenyls on osmoregulatory response and apoptosis in GIFT tilapia, Oreochromis niloticus
Authors: Y. Zheng, L. Qiu, L. Fan, C. Song, S. Meng and J. Chen
In the present study, GIFT tilapia Oreochromis niloticus were exposed to polychlorinated biphenyls (PCBs) for 7, 14, and 21 days. Over the duration of the exposure, genotoxicity and the activity of Na+/K+-ATPase (NKA) and Ca+/Mg+-ATPase (CMA) were measured in the gill, kidney, and intestine, to evaluate changes in osmoregulatory response in O. niloticus. .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038620
- DOI:
- 10.4238/gmr.15038620
Isolation and characterization of microsatellite markers for Eucommia ulmoides (Eucommiaceae), an endangered tree, using next-generation sequencing
Authors: W.R. Zhang, Y. Li, J. Zhao, C.H. Wu, S. Ye and W.J. Yuan
Eucommia ulmoides Oliver, a single extant species of Eucommiaceae, is an endemic dioecious tree in China. The natural resources of E. ulmoides have rapidly declined in recent years because of the over-collection of its cortex. To design a suitable protection strategy, it is necessary to develop a set of molecular markers to in.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027789
- DOI:
- 10.4238/gmr.15027789
Genetic potential of common bean progenies obtained by different breeding methods evaluated in various environments
Authors: V.A. Pontes J�ºnior, P.G.S. Melo, H.S. Pereira and L.C. Melo
Grain yield is strongly influenced by the environment, has polygenic and complex inheritance, and is a key trait in the selection and recommendation of cultivars. Breeding programs should efficiently explore the genetic variability resulting from crosses by selecting the most appropriate method for breeding in segregating popu.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038622
- DOI:
- 10.4238/gmr.15038622
Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress
Authors: R. Buriro, Y.J. Lv, I. Ali, S. Tang, Z.J. Liu, M. Zhang, A. Adem, J. Hartung and E.D. Bao
The mechanisms involved in sudden animal death due to acute heart failure during heat stress are not well understood. We examined the relationship between heat stress-induced variations of protective Hsp60 and expression of its regulatory factor, HSF-1, in heat-stressed primary myocardial cells of neonatal rats in vitro through cardiac enzyme detection, i.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.20.2
- DOI:
- 10.4238/2013.August.20.2