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DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis
Authors: C.H. Liu,T. Tao1,L. Jiang1,B. Xu,L. Zhang, K. Lu,X.W. Zhang,S.Q. Chen,D.C. Liu and M. Chen
Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of va.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.14
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.14
Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-�± production via MAPK pathway in leukemic cell lines
Authors: C. Parnsamut and S. Brimson
Silver nanopaticles (AgNPs) and gold nanoparticles (AuNPs) have various applications in medical healthcare and various biological properties such as anti-inflammation, anti-cancer, and anti-angiogenesis. In this study, we investigated the effect of AgNPs and AuNPs on cytokine production via the mitogen-activated protein kinase pathway in leukemic cell lin.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.15
Identification and characterization of novel NBS-LRR resistance gene analogues from the pea
Authors: S. Djebbi, D. Bouktila, H. Makni, M. Makni and M. Mezghani-Khemakhem1
Pea (Pisum sativum) is one of the most cultivated legumes in the world, and its yield and seed quality are affected by a variety of pathogens. In plants, NBS-LRR (nucleotide binding siteleucine-rich repeat) is the main class of disease resistance genes. Using degenerate primers deduced from conserved motifs in the NBS domain of known resistance genes, we .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.18
- DOI:
- 10.4238/2015.June.11.18
Genome-wide pathway analysis in amyotrophic lateral sclerosis
Authors: Y.H. Lee and G.G. Song
The aims of this study were to identify candidate singlenucleotide polymorphisms (SNPs) and mechanisms of amyotrophic lateral sclerosis (ALS) and to generate SNP-to-gene-to-pathway hypotheses. An ALS genome-wide association study (GWAS) dataset that included 483,051 SNPs in 276 patients with ALS and 271 controls of European descent was used in this study... Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.19
- DOI:
- 10.4238/2015.June.11.19
Association between IL-10-G1082A polymorphisms and the development of coronary artery disease in a Chinese population
Authors: K. Liang, S.R. Dong and H. Peng
We conducted a case-control study to investigate the association between IL-10-G1082A (rs1800896) polymorphism and the development of coronary artery disease (CAD) in the Chinese population. We recruited 295 CAD patients and 355 healthy controls from the Fifth Affiliated Hospital of Zhengzhou University between April 2012 and .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027933
- DOI:
- 10.4238/gmr.15027933
Characterization of Aspergillus niger ndo-1,4-�²-glucanase ENG1 secreted from Saccharomyces cerevisiae using different expression vectors
Authors: S.M. Taipakova, I.T. Smekenov, M.K. Saparbaev and A.K. Bissenbaev
Heterologous expression of Aspergillus niger endo-1,4- β-glucanase (ENG1) in Saccharomyces cerevisiae was tested both with an episomal plasmid vector (YEGAp/eng1) and a yeast vector capable of integration into the HO locus of the S. cerevisiae chromosome (pHOGAPDH-eng1-KanMX4-HO). In both cases, eng1 gene expression in yeast, with its native signal s.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.20
- DOI:
- 10.4238/2015.June.11.20
Assessment of apple core collections constructed using phenotypic and genotypic data
Authors: W.H. Yun, S.H. Ban, G.H. Kim, J.-H. Kim, S.I. Kwon and C. Choi
Several types of information can be used to select core collections, including passport data, agronomic data, and molecular data. However, little is known about the ability of core collections to retain the genetic diversity and structure of the whole collection for characters that were not considered during the selection, particularly when molecular mark.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.21
- DOI:
- 10.4238/2015.June.11.21
Polymorphisms in GSTM1, GSTT1, GSTP1, and GSTM3 genes and breast cancer risk in northeastern Mexico
Authors: G. Jaramillo-Rangel, M. Ortega-MartÃ?Ânez, R.M. Cerda-Flores andH.A. Barrera-SaldaÃ?±a
Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The pur.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.22
- DOI:
- 10.4238/2015.June.11.22
Genetic variability in isolates of Chromobacterium violaceum from pulmonary secretion, water, and soil
Authors: A.C. Santini, J.T. Magalh�£es, J.C.M. Cascardoâ� and R.X. Corr�ªa
Chromobacterium violaceum is a free-living Gram-negative bacillus usually found in the water and soil in tropical regions, which causes infections in humans. Chromobacteriosis is characterized by rapid dissemination and high mortality. The aim of this study was to detect the genetic variability among C. violaceum type strain A.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027955
- DOI:
- 10.4238/gmr.15027955
Simultaneous selection for cowpea (Vigna unguiculata L.) genotypes with adaptability and yield stability using mixed models
Authors: F.E. Torres, P.E. Teodoro, E.V. Rodrigues, A. Santos, A.M. Corr�ªa, G. Ceccon
The aim of this study was to select erect cowpea (Vigna unguiculata L.) genotypes simultaneously for high adaptability, stability, and yield grain in Mato Grosso do Sul, Brazil using mixed models. We conducted six trials of different cowpea genotypes in 2005 and 2006 in Aquidauana, Chapadão do Sul, Dourados, and Primave.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028272
- DOI:
- 10.4238/gmr.15028272