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Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension
Authors: J. Jia, C. Men, K.-T. Tang and Y.-Y. Zhan
We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.10
- DOI:
- 10.4238/2015.June.12.10
Varicocele and male infertility in Northeast China: Y chromosome microdeletion as an underlying cause
Authors: R.L. Dai,Y. Hou,F.B. Li, J.M. Yue,Q. Xi and R.Z. Liu
The prevalence of Y chromosome microdeletions among azoospermic, severe oligozoospermic, moderate oligozoospermic, and mild oligozoospermic patients with varicocele-related and idiopathic infertility shows conflicting data in Asian countries. We aimed to detect this frequency in Northeast China, and investigated spermatogenic defects whether associated wi.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.12.13
- DOI:
- 10.4238/2015.June.12.13
Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo
Authors: H. Wu, K. Wang, W. Liu and Q. Hao
Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-revers.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.1
- DOI:
- 10.4238/2015.June.18.1
Mapping and validation of Xanthomonas citri subsp citri genes regulated by putative plant-inducible promoter box (PIP-box)
Authors: F.M.S. Carvalho, J.C.F. Oliveira, M.L. Laia, T.R. Jacob,R.M. Ferreira, M.I.T. Ferro, R.I.D. Tezza, S.M. Zingaretti, C.F. Silva and J.A. Ferro
Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), is a major disease affecting citriculture worldwide, because of the susceptibility of the host and the lack of efficient control methods. Previous studies have reported that some genes of phytopathogenic bacteria possess a consensus nucle.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028428
- DOI:
- 10.4238/gmr.15028428
Clinical features of allergic rhinitis in children of Shanghai, China
Authors: S. He, Y.J. Li and J. Chen
The aims of the current study were to assess the clinical features of allergic rhinitis (AR) in children in Shanghai. Serum-specific IgE (sIgE) tests were performed on samples from patients with AR symptoms from January 2011 to December 2014. A disease-related questionnaire was completed after AR diagnosis. The allergen profil.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028118
- DOI:
- 10.4238/gmr.15028118
Nucleotide variation in the Toxoplasma gondii micronemal protein 8 gene
Authors: Z.Y. Li, H.Q. Song, C.R. Wang and X.Q. Zhu
Toxoplasma gondii is a successful opportunistic protozoan distributed worldwide, which can infect all vertebrates, leading to serious infection, blindness, and abortion. Micronemal (MIC) proteins are critically important for T. gondii infection, as they participate in various stages of the Toxoplasma life cycle, including inva.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028578
- DOI:
- 10.4238/gmr.15028578
Biological correlation between glucose transporters, Ki-67 and 2-deoxy-2-[18F]-fluoro-D-glucose uptake in diffuse large B-cell lymphoma and natural killer/T-cell lymphoma
Authors: Y.M. Liu, X.M. Zhai and Y.W. Wu
The purpose of this study was to investigate the association between cellular 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) uptake and the expression of several subtypes of glucose transporters (GLUT) and Ki-67 in diffuse large B-cell lymphoma (DLBCL) and natural killer (NK)/T-cell lymphoma (NKTCL). Cell lines were histologically.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027242
- DOI:
- 10.4238/gmr.15027242
Effect of siRNA-induced silencing of cellular prion protein on tyrosine hydroxylase expression in the substantia nigra of a rat model of Parkinson�s disease
Authors: X. Wang, H.A. Yang, X.N. Wang and Y.F. Du
The most significant pathological feature of Parkinson’s disease (PD) is the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Currently, available treatments for PD cannot prevent the loss of DA neurons. Tyrosine hydroxylase (TH) expressed in substantia nigra neurons catalyzes the conversion.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027406
- DOI:
- 10.4238/gmr.15027406
Population structure of jatropha and its implication for the breeding program
Authors: D.N. Santos, J.L. Ferreira, M. Pasqual, A.L. Generoso3, T.A. Setotaw, G.M.A. Can�§ado and W.A. Vendrame
Jatropha (Jatropha curcas L.) has potential as an oilseed crop that requires the development of technology for its exploitation. The objective of this study was to assess the population structure and the genetic diversity in jatropha accessions at a global level using simple sequence repeat (SSR) molecular markers. Jatropha accessions (N = 109) from 10 co.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017770
- DOI:
- 10.4238/gmr.15017770
Phylogenetic relationships among Octopodidae species in coastal waters of China inferred from two mitochondrial DNA gene sequences
Authors: Z.M. L�¼, W.T. Cui, L.Q. Liu, H.M. Li and C.W. Wu
Octopus in the family Octopodidae (Mollusca: Cephalopoda) has been generally recognized as a “catch-all” genus. The monophyly of octopus species in China’s coastal waters has not yet been studied. In this paper, we inferred the phylogeny of 11 octopus species (family Octopodidae) in China’s coastal waters using nucleotide sequences.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.7
- DOI:
- 10.4238/2013.September.19.7