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Role of PPAR�± in down-regulating AGE-induced TGF-�² and MMP-9 expressions in chondrocytes
Authors: J. Wang, G. Wang and G.W. Sun
Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogres.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027963
- DOI:
- 10.4238/gmr.15027963
Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people
Authors: R. Liang, X.X. Yan, Y. Lin, Q. Li, C.L. Yuan, Z.H. Liu and Y.Q. Li
Cyclooxygenase-2 (COX-2) influences carcinogenesis through regulation of angiogenesis, apoptosis, cytokine expression, and immune response suppression. It has been well established that COX-2 is overexpressed in a variety of human cancers, such as hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the associat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028093
- DOI:
- 10.4238/gmr.15028093
Analysis of FOS, BTG2, and NR4A in the function of renal medullary hypertension
Authors: Y.B. Wu, W.D. Zang, W.Z. Yao, Y. Luo, B. Hu, L. Wang and Y.L. Liang
The aim of this study was to identify differentially expressed genes (DEGs) in renal medullary hypertension and reveal their pathogenic mechanisms. We downloaded the gene expression profile of GSE28360 from the Gene Expression Omnibus database. The profile included 14 samples (5 normal and 9 hypertension). The DEGs in normal and disease samples were disti.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.4
- DOI:
- 10.4238/2013.September.19.4
Protective effect of the n-butanol Toona sinensis seed extract on diabetic nephropathy rat kidneys
Authors: W.Z. Li, X.H. Wang, H.X. Zhang, S.M. Mao and C.Z. Zhao
The objective of this study was to observe the protective effect of the n-butyl alcohol phase of Toona sinensis seed extract on the kidneys of diabetic nephropathy (DN) rats and its preliminary mechanism. Male wistar rats were administered a normal or high-fat diet for 1 month. DN rats were divided into a model group and a pet.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017403
- DOI:
- 10.4238/gmr.15017403
Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease
Authors: E.M. Merzetti and B.E. Staveley
F-box proteins act as the protein recognition component of the Skp-Cul-F-box class of ubiquitin ligases. Two members of a gene sub-family encoding these proteins, FBXO7 and FBXO32, have been implicated in the onset and progression of degenerative disease. FBXO7 is responsible for rare genetic forms of Parkinson disease, while .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028579
- DOI:
- 10.4238/gmr.15028579
Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage
Authors: L. Luo, D.H. Li, S.G. Wei, H.B. Zhang, S.B. Li and J. Zhao
Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are contr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.6
- DOI:
- 10.4238/2013.September.23.6
Bean (Phaseolus vulgaris L.) lines: chemical composition and protein digestibility
Authors: F.R. Mesquita, M.I.A. Silva and A.D. Corr�ªa
The bean represents the main source of proteins for the low income populations, although the digestibility of those proteins is relatively low. Consequently, the programs of plant genetic breeding have been working on the search for new lines with higher protein levels. Thus, with the purpose of supplying information to the re.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028587
- DOI:
- 10.4238/gmr.15028587
Development of highly polymorphic EST-SSR markers and segregation in F1 hybrid population of Vitis vinifera L.
Authors: E. Kayesh, Y.Y. Zhang, G.S. Liu, N. Bilkish, X. Sun, X.P. Leng and J.G. Fang
The objectives of this investigation were to develop and validate the expressed sequence tag (EST)-simple sequence repeat (SSR) markers from large EST sequences, and to study the segregation and distribution of SSRs within two grapevine parental lines. In total, 94 F1 lines crossed between “Early Rose” and “Red Globe” were studied... Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.5
- DOI:
- 10.4238/2013.September.23.5
Mixture of polysaccharide and nucleic acid extracted from Bacillus Calmette-Guerin (BCG) enhances immune response of infectious bursal disease virus vaccine in chickens
Authors: X.B. Wang, Z.J. Liu, Y.J. Lv, Y. Long and E.D. Bao
In this study, the immune response induced by a mixture of polysaccharide and nucleic acid extracted from Bacillus Calmette-Guerin (BCG) was evaluated in chickens inoculated with infectious bursal disease virus (IBDV) vaccine. After the mixture was injected intramuscularly at a dose of 0.075, 0.15 or 0.3 mg·kg-1·.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15025523
- DOI:
- 10.4238/gmr.15025523
Effect of glycerol on GHR and IGF-1 gene expression in breast muscle and on growth of Japanese meat quails
Authors: S.C.C. Silva, E. Gasparino, D.M. Voltolini, A.V. Pires, F. Tanamati, A.L.S. Garcia and D.P. de Oliveira
We evaluated messenger RNA (mRNA) expression of the growth-hormone (GHR) and insulin-like growth factor (IGF-1) genes in 28-day-old Japanese meat quails fed diets containing 0, 8, or 12% dietary glycerol in substitution of corn. Total RNA was extracted from the breast muscle and the DNA was amplified with specific primers using real-time PCR. Feed convers.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.3
- DOI:
- 10.4238/2013.September.23.3