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Time-series microarray data simulation modeled with a case-control label
Authors: Y.J. Liu and J.Y. Zhang
With advances in molecular biology, microarray data have become an important resource in the exploration of complex human diseases. Although gene chip technology continues to grow, there are still many barriers to overcome, such as high costs, small sample sizes, complex procedures, poor repeatability, and the dependence on da.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027287
- DOI:
- 10.4238/gmr.15027287
Fine mapping and characterization of a novel dwarf and narrow-leaf mutant dnl1 in rice
Authors: X.J. Wei, S.Q. Tang, G.N. Shao, M.L. Chen, Y.C. Hu and P.S. Hu
Plant height is one of the most important agronomic traits of rice (Oryza sativa). Dwarf mutants are ideal materials for research on the mechanisms of regulation of rice plant height. We examined a new dwarf and narrow-leaf mutant dnl1. Phenotypic analysis showed that the dnl1 mutant has a thinner culm and more tillers, but the number of grains per panicl.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.2
- DOI:
- 10.4238/2013.September.23.2
Expression of a GDP-L-galactose phosphorylase-like gene in a Chinese wild Vitis species induces responses to Erysiphe necator and defense signaling molecules
Authors: H.M. Hou, H.E. Li, M. Gao, H. Wang, C. Jiao and X.P. Wang
Using rapid amplification of cDNA ends, a full-length cDNA sequence of a GDP-L-galactose phosphorylase-like gene was isolated from leaves infected by Erysiphe necator in the Chinese wild (Vitis pseudoreticulata) clone, ‘Baihe-35-1’, an E. necator-resistant genotype. The full-length cDNA, designated as VpVTC, comprised 1943 bp and putatively en.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.1
- DOI:
- 10.4238/2013.September.23.1
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population
Authors: B. Yang, J.R. Xu, X.M. Liu, Y. Yang, X.F. Na, M. Li and Y.J. Wang
We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significa.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.26.2
- DOI:
- 10.4238/2013.March.26.2
Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population
Authors: L.J. Cui, X.Y. Chang, L.Y. Zhu, G. Feng, T. Zhou, C.X. Zhang, K.Y. Chong and K. Sun
Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh popu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027503
- DOI:
- 10.4238/gmr.15027503
miRQuest: integration of tools on a Web server for microRNA research
Authors: R.R. Aguiar, L.A. Ambrosio, G. Sep�?ºlveda-Hermosilla, V. Maracaja-Coutinho and A.R. Paschoal
This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA (miRNA) identification that use different programming languages and methods to realize this task. It is diffic.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016861
- DOI:
- 10.4238/gmr.15016861
De novo assembly and characterization of farmed blue fox (Alopex lagopus) global transcriptome using Illumina paired-end sequencing
Authors: P.C. Guo1*, S.Q. Yan1*, S. Si1, C.Y. Bai1, Y. Zhao1, Y. Zhang1, J.Y. Yao2 and Y.M. Li1
The blue fox (Alopex lagopus), a coat-color variant of the Arctic fox, is a domesticated fur-bearing mammal. In the present study, transcriptome data generated from a pool of nine different tissues were obtained with Illumina HiSeq2500 paired-end sequencing technology. After filtering from raw reads, 32,358,290 clean reads wer.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017603
- DOI:
- 10.4238/gmr.15017603
Positive evolution of the glycoprotein (GP) gene is related to transmission of the Ebola virus
Authors: Y.X. Jing, L.N. Wang, X.M. Wu and C.X. Song
Ebola hemorrhagic fever is a fatal disease caused by the negative-strand RNA of the Ebola virus. A high-intensity outbreak of this fever was reported in West Africa last year; however, there is currently no definitive treatment strategy available for this disease. In this study, we analyzed the molecular evolutionary history a.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017173
- DOI:
- 10.4238/gmr.15017173
Association of the G403A polymorphism in the RANTES gene with coronary artery disease: a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was p.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.10
- DOI:
- 10.4238/2013.September.23.10
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease
Authors: Y.Y. Chen, B.N. Wang and X.P. Yu
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An addit.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017238
- DOI:
- 10.4238/gmr.15017238