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Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome
Authors: V.R.A. Vargas, S.L. Bonatto, F.E. Macagnan, A.M.P. Feoli, C.S. Alho, N.D.V. Santos and V.M. Schmitt
We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.8
- DOI:
- 10.4238/2013.February.28.8
A new method for estimating the number of non-differentially expressed genes
Authors: J. Wu, C.Y. Liu, W.T. Chen, W.Y. Ma and Y. Ding
Control of the false discovery rate is a statistical method that is widely used when identifying differentially expressed genes in high-throughput sequencing assays. It is often calculated using an adaptive linear step-up procedure in which the number of non-differentially expressed genes should be estimated accurately. In this paper, we discuss the estim.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017402
- DOI:
- 10.4238/gmr.15017402
Prediction of health risk due to polycyclic aromatic hydrocarbons present in urban air in Rio de Janeiro, Brazil
Authors: C.R. Rainho, A.M.A. Velho, S.M. Corr�ªa, J.L. Mazzei, C.A.F. Aiub and I. Felzenszwalb
Risk assessment can provide a comprehensive estimate of potential effects of contaminants under specific, well-defined, and well-described circumstances, providing quantitative relationships between exposure and effects to identify and to define areas of concern. We investigated the mutagenic activity of particulate matter in air samples collected from th.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.6
- DOI:
- 10.4238/2013.February.28.6
Molecular characterization of endophytes isolated from Saccharum spp based on esterase and ribosomal DNA (ITS1-5.8S-ITS2) analyses
Authors: A.C. Leme, M.R.R. Bevilaqua, S.A. Rhoden, C.A. Mangolin, M.F.P.S. Machado and J.A. Pamphile
This study used esterases and ribosomal DNA (rDNA) markers to determine endophytic variability in order to better understand endophyte-host interactions. Polyacrylamide gel electrophoresis and esterase isoenzymes (EST; EC 3.1.1.3), with a-naphthyl acetate and β-naphthyl acetate as substrates, were used to assess relationships among endophytes. ITS1-5.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.11
- DOI:
- 10.4238/2013.September.27.11
Fast protocol for extraction of DNA from Prosopis spp leaves (plant adapted to arid environment) without liquid nitrogen
Authors: C.Y. Michel-L�³pez, D. Gonz�¡lez-Mendoza and O. Grimaldo-Juarez
The extraction of high-quality genomic DNA from Prosopis spp for polymerase chain reaction (PCR) amplification is complicated, owing to the presence of a high percentage of secondary metabolites that bind to or co-precipitate with nucleic acids. In the present study, we report a modified sodium dodecyl sulfate/phenol protocol that eliminates the use of li.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.10
- DOI:
- 10.4238/2013.September.27.10
Identification of a locus characteristic of male individuals of buffalo grass [Buchloe dactyloides (Nutt.) Engelm.] by using an RAPD marker
Authors: Y.X. Li, X.G. Wang, C.H. Yang, L.L. Cong, F.F. Wu, J.G. Xue and Y.H. Han
Buffalo grass [Buchloe dactyuloides (Nutt.) Engelm.] plants can be either male, female, or hermaphrodite (monoecious). As there is no morphological difference in the early vegetative growth of these three classes of plants, it is worthwhile to use molecular biological methods to attempt to identify the sex of a plant at this early growth period. In this s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.27.8
- DOI:
- 10.4238/2013.September.27.8
Effect of morphine preconditioning in the delayed phase on the expression of p38 mitogen-activated protein kinase in a rabbit model of myocardial ischemia-reperfusion injury
Authors: K. Ran, Z.X. Gong, D.L. Yang, Y.T. Chang, K.M. Duan and Y.W. Ou
This study aimed to investigate the protective effects of delayed morphine preconditioning on myocardial ischemia-reperfusion injury. We randomly divided 30 rabbits into three groups with 10 rabbits in each group as follows: sham operation group (C group), ischemia-reperfusion group (I/R group), and morphine pretreatment group (M group). Rabbits in C Grou.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.7
- DOI:
- 10.4238/2015.June.18.7
Unicentric Castleman disease located in the anterior mediastinum misdiagnosed as invasive thymoma: a case report
Authors: Y. Liu, D.Y. Xie, X.M. Lin and C. Chi
Castleman disease is a rare lymphoproliferative disorder of unknown etiology. The localized form, which usually presents as a slow-growing mass, is most commonly located in the mediastinum. Invasion of the vena anonyma by a mass has rarely been reported. We herein describe a case of initially misdiagnosed invasive thymoma in a 72-year-old woman, but posto.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.10
- DOI:
- 10.4238/2015.June.18.10
Construction of an integrated genetic map for Capsicum baccatum L.
Authors: M.M. Moulin, R. Rodrigues, H.C.C. Ramos, C.S. Bento, C.P. Sudr�©, L.S.A. Gon�§alves and A.P. Viana
Capsicum baccatum L. is one of the five Capsicum domesticated species and has multiple uses in the food, pharmaceutical and cosmetic industries. This species is also a valuable source of genes for chili pepper breeding, especially genes for disease resistance and fruit quality. However, knowledge of the genetic structure of C. baccatum is limited. A refer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.12
- DOI:
- 10.4238/2015.June.18.12
Detection of drug-resistance mechanism of Pseudomonas aeruginosa developing from a sensitive strain to a persister during carbapenem treatment
Authors: J.L. Shen and Y.P. Fang
We explored the mechanism of the development from sensitivity to resistance to carbapenem in Pseudomonas aeruginosa. Two P. aeruginosa strains were collected during treatment with carbapenem. Strain homology was investigated using pulsed-field gel electrophoresis. Porin oprD2 expression was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophor.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.16
- DOI:
- 10.4238/2015.June.18.16