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Characterization and expression analysis of the prophenoloxidase activating factor from the mud crab Scylla paramamosain
Authors: J. Wang, K.J. Jiang, F.Y. Zhang, W. Song, M. Zhao, H.Q. Wei, Y.Y. Meng and L.B. Ma
Prophenoloxidase activating factors (PPAFs) are a group of clip domain serine proteinases that can convert prophenoloxidase (pro-PO) to the active form of phenoloxidase (PO), causing melanization of pathogens. Here, two full-length PPAF cDNAs from Scylla paramamosain (SpPPAF1 and SpPPAF2) were cloned and characterized. The full-length SpPPAF1 cDNA was 167.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.8
- DOI:
- 10.4238/2015.August.3.8
Feasibility of comfortable and secure intubation achieved with the Disposcope endoscope or Macintosh laryngoscope for patients in whom glottis viewing is difficult
Authors: X.-H. Li,Z. Sun and L.-L. He
We aimed to study the feasibility of a comfortable and secure intubation achieved with the Disposcope endoscope or Macintosh laryngoscope when glottis viewing is difficult. Forty adults scheduled for elective surgery under general anesthesia, in whom glottis viewing was difficult with the Macintosh laryngoscope (classified as Cormack-Lehane Grade III or I.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.19
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.19
Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes
Authors: J. Wang, T. Zou, H.X. Yang, Y.Z. Gong, X.J. Xie, H.Y. Liu and D.F. Liao
Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM). Interaction of insulin with the insulin receptor (IR) leads to both its auto-phosphorylation and phosphorylation of tyrosine residues on the IR substrate (IRS) proteins, initiating the activation of intracellular signaling cascades. The metabolic effects of IRS are known t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.5
- DOI:
- 10.4238/2015.August.3.5
Prediction of core cancer genes using a hybrid of feature selection and machine learning methods
Authors: Y.X. Liu, N.N. Zhang, Y. He and L.J. Lun
Machine learning techniques are of great importance in the analysis of microarray expression data, and provide a systematic and promising way to predict core cancer genes. In this study, a hybrid strategy was introduced based on machine learning techniques to select a small set of informative genes, which will lead to improving classification accuracy. Fi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.10
- DOI:
- 10.4238/2015.August.3.10
Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population
Authors: L.M. Qin, G.M. Qin, X.H. Shi, A.L. Wang and H. Zuo
We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with contro.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027632
- DOI:
- 10.4238/gmr.15027632
Role of adiponectin in adipose tissue wound healing
Authors: C.E. Jin, L. Xiao, Z.H. Ge, X.B. Zhan and H.X. Zhou
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.11
- DOI:
- 10.4238/2015.August.3.11
Impact of adherence to GOLD guidelines on 6-minute walk distance, MRC dyspnea scale score, lung function decline, quality of life, and quality-adjusted life years in a Shanghai suburb
Authors: Y.Q. Jiang, Y.X. Zhu, X.L. Chen, X. Xu, F. Li, H.J. Fu, C.Y. Shen, Y.Y. Lu, Q.J. Zhuang, G. Xu, Y.Y. Cai, Y. Zhang, S.S. Liu, M.Y. Zhu and S.H. Li
We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructivepulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.9
- DOI:
- 10.4238/2015.August.3.9
Transthoracic closure of atrial septal defect and ventricular septal defect without cardiopulmonary bypass
Authors: L. Wan,B.-T. Yu,Q.-C. Wu,L. Zeng,Q. Wang,J. Tang,Q.-R. Xu,H. Xu,W.-J. Wang,Y.-P. Cao and J.-C. Liu
The minimally invasive surgical transthoracic occlusion of an atrial septal defect (ASD) or a ventricular septal defect (VSD) is an increasingly widespread alternative treatment for congenital heart disease. The aim of this study is to summarize our clinical experience with minimally invasive surgical transthoracic occlusion of ASD and VSD without cardiop.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.4
Development and characterization of microsatellite markers for Ulmus chenmoui (Ulmaceae), an endangered tree endemic to eastern China
Authors: Q.F. Geng, J. He, J. Yang, E. Shi, D.B. Wang, W.X. Xu,N. Jeelani Z.S. Wang and H. Liu
Ulmus chenmoui (Ulmaceae) is an endangered tree found on Langya Mountain, eastern China. To better understand the population genetics of U. chenmoui and conserve the species, we developed microsatellite markers. Using a suppression-polymerase chain reaction technique, 74 compound microsatellite primer pairs were designed. Twel.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027985
- DOI:
- 10.4238/gmr.15027985
Synonymous codon selection in the hepatitis B virus translation initiation region
Authors: M.-R. Ma, L. Hui, M.-L. Wang, Y. Tang, Y.-W. Chang, Q.-H. Jia, X.-P. Yang, X.-H. Wang and X.-Q. Ha
Hepatitis B virus (HBV) infection is a major health problem worldwide. This virus and its hosts are often fated to continual co-evolutionary interactions. Codon usage analysis has significance for studies of co-evolution between viruses, their hosts, and mRNA translation. Adaptation of the overall codon usage pattern of HBV to that of humans is estimated .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.4
- DOI:
- 10.4238/2015.August.7.4