Se
Development of novel polymorphic microsatellite markers for the blood clam Tegillarca granosa by pyrosequencing
Authors: Y.H. Dong, H.H. Yao, S.F. Shi, Y.B. Bao and Z.H. Lin
Large amounts of expressed sequence tags (ESTs) generated using next-generation sequencing technologies provide a cost-effective and valuable genomic resource for the development of microsatellite markers. In this study, we isolated 115 novel polymorphic microsatellite markers for the blood clam Tegillarca granosa from ESTs in 454 sequencing data. All the.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.6
- DOI:
- 10.4238/2015.August.7.6
Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma
Authors: Z.Y. Ni, F.O. Lin, D.F. Liu and J. Xiao
MicroRNA-143 serves as a tumor suppressor in many human malignancies. However, its involvement in oral squamous cell carcinoma (OSCC) is still unclear. In this study, we investigated the effects of miR-143 in OSCC tumorigenesis and development. Using real-time quantitative reverse transcription-polymerase chain reaction, we detected miR-143 expression in .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.2
- DOI:
- 10.4238/2015.June.26.2
Association between MTHFR 677C/T polymorphism and psoriasis risk:a meta-analysis
Authors: J.H. Qi,J.H. Qi,N. Shi,Y.J. Chen and G. Nie
Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.16
Role of inflammatory responses in the pathogenesis of human cerebral aneurysm
Authors: X.J. Fan, H.D. Zhao, G. Yu, X.L. Zhong, H. Yao and Q.D. Yang
We aimed to detect expressional profiles of intracellular cell adhesion molecule-1 (ICAM-1), nuclear factor-kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) in human cerebral aneurysm, in order to investigate the effect of chronic inflammation on the pathogenesis of cerebral aneurysm. Samples from 40 cases of human cerebral aneurysms .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.15
- DOI:
- 10.4238/2015.August.7.15
Association between 1p13.3 genomic markers and coronary artery disease: a meta-analysis involving patients and controls
Authors: J. Guo, Y.X. Luo, L.X. Tao1 and X.H. Guo
Recently, genome-wide association studies on cardiovascular disease identified a series of associated single nucleotide polymorphisms in an intergenic region of chromosome 1p13.3. We investigated the association of this locus with cardiovascular disease in 13 case-control studies and undertook a meta-analysis for effect size, heterogeneity, publ.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.18
- DOI:
- 10.4238/2015.August.7.18
Models of logistic regression analysis, support vector machine, and back-propagation neural network based on serum tumor markers in colorectal cancer diagnosis
Authors: B. Zhang, X.L. Liang, H.Y. Gao, L.S. Ye and Y.G. Wang
We evaluated the application of three machine learning algorithms, including logistic regression, support vector machine and back-propagation neural network, for diagnosing congenital heart disease and colorectal cancer. By inspecting related serum tumor marker levels in colorectal cancer patients and healthy subjects, early d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028643
- DOI:
- 10.4238/gmr.15028643
PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer
Authors: F.S. Ramos, L.T.R. Serino, C.M.S. Carvalho, R.S. Lima, C.A. Urban, I.J. Cavalli and E.M.S.F. Ribeiro
Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia. We evaluated the expression of PDIA3 and PDIA6 in invasive ductal carcinomas. Using reverse transcription-quantitative polymerase chain reaction, we compared the mRNA expression level .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.4
- DOI:
- 10.4238/2015.June.26.4
Inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells by erythropoietin via activating ERK and P38 MAPK
Authors: G.X. Liu, J.C. Zhu, X.Y. Chen, A.Z. Zhu, C.C. Liu, Q. Lai and S.T. Chen
We examined whether erythropoietin (EPO) can inhibit adipogenic differentiation of mesenchymal stem cells (MSCs) in the mouse bone marrow and its underlying mechanism. We separated and extracted mouse bone marrow MSCs and induced adipogenic differentiation using 3-isobutyl-1-methylxanthine, insulin, and dexamethasone. Different concentrations of EPO were .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.5
- DOI:
- 10.4238/2015.June.26.5
Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels
Authors: D.I. Rodin, A.L. Schwarzman and S.V. Sarantseva
Amyloid precursor protein (APP) is a key player in Alzheimer’s disease. The proteolytic cleavage of APP results in various short peptide fragments including the toxic amyloid-beta peptide, which is a main component of senile plaques. However, the functions of APP and its processed fragments are not yet well understood. Here, using real-time polymera.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.2
- DOI:
- 10.4238/2015.August.10.2
S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation
Authors: Y.J. Sun, X.K. Wang and B.J. Li
We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.4
- DOI:
- 10.4238/2015.August.10.4