Se
The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease
Authors: S. Simsek, S. Tekes, D. Oral, A. Turkyilmaz, B. Isik, M.R. Isik and H. Akkoc
An insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoki.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.10
- DOI:
- 10.4238/2013.April.25.10
Implications of mitotic and meiotic irregularities in common beans (Phaseolus vulgaris L.)
Authors: D.C. Lima, G.T. Braz, G.B. dos Reis, V.H. Techio, L.C. Davide and A. de F.B. Abreu
The common bean has great social and economic importance in Brazil and is the subject of a high number of publications, especially in the fields of genetics and breeding. Breeding programs aim to increase grain yield; however, mitosis and meiosis represent under explored research areas that have a direct impact on grain yield... Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027749
- DOI:
- 10.4238/gmr.15027749
Genetic diversity among Puccinia melanocephala isolates from Brazil assessed using simple sequence repeat markers
Authors: R.F. Peixoto-Junior, S. Creste, M.G.A. Landell, D.S. Nunes, A. Sanguino, M.F. Campos, R. Vencovsky, E.V. Tambarussi and A. Figueira
Brown rust (causal agent Puccinia melanocephala) is an important sugarcane disease that is responsible for large losses in yield worldwide. Despite its importance, little is known regarding the genetic diversity of this pathogen in the main Brazilian sugarcane cultivation areas. In this study, we characterized the gen.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.23
- DOI:
- 10.4238/2014.September.26.23
Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis
Authors: L.N. Xu, N. Lin, B.N. Xu, J.B. Li and S.Q. Chen
The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.2
- DOI:
- 10.4238/2015.December.11.2
Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer
Authors: Y.H. Liu and W.L. Zhu
In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.12
- DOI:
- 10.4238/2015.December.11.12
Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis
Authors: P. Yuan, L. Yuan, B.L. Xu, C.Z. Wang, H.Z. Yang and Y. Li
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.15
- DOI:
- 10.4238/2015.December.11.15
Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis
Authors: J.L. Huan, X. Gao, L. Xing, X.J. Qin, H.X. Qian, Q. Zhou and L. Zhu
The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.5
- DOI:
- 10.4238/2014.September.29.5
Cellulolytic activity and structure of symbiotic bacteria in locust guts
Authors: L.-J. Su, H. Liu, Y. Li, H.-F. Zhang, M. Chen, X.-H. Gao, F.-Q. Wang and A.-D. Song
Locusts are able to digest the cellulose of Gramineae plants, resulting in their being considered as major crop pests. To illustrate the mechanism involved in cellulose digestion, the cellulolytic activity and zymography in the gut contents of 16 locust species were determined using carboxymethyl cellulose (CMC) as substrate. .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.6
- DOI:
- 10.4238/2014.September.29.6
Multi-threading the generation of Burrows-Wheeler Alignment
Authors: H. Jo
Along with recent progress in next-generation sequencing technology, it has become easier to process larger amounts of genome sequencing data at a lower cost. The most time-consuming step of next-generation sequencing data analysis involves the mapping of read data into a reference genome. Although the Burrows-Wheeler Alignmen.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028650
- DOI:
- 10.4238/gmr.15028650
Dietary zinc may attenuate heat-induced testicular oxidative stress in mice via up-regulation of Cu-Zn SOD
Authors: Y. Cao, Y.S. Li, Z.J. Li, F. Wang and C.M. Li
Zinc (Zn) is important for male mammalian reproduction. In this study, we sought to clarify the role of Zn in heat-induced testicular damage in mice. Eighteen mice were divided into either control (con), heat (heat) and heat plus Zn (H+Zn) treatment groups, and fed diets containing 60 (con and heat groups) or 300 (H+Zn group) mg/kg Zn sulfate for one mont.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.9
- DOI:
- 10.4238/2015.December.11.9