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Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine
Authors: D.F. Jiang, X.G. Zhang, H.L. Yang and C. Sun
Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously inj.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.January.4.13
- DOI:
- 10.4238/2013.January.4.13
Selection in sugarcane based on inbreeding depression
Authors: A.A.C. de Azeredo, L.L. Bhering, B.P. Brasileiro, C.D. Cruz and M.H.P. Barbosa
This study aimed to evaluate the gene action associated with yield-related traits, including mean stalk weight (MSW), tons of sugarcane per hectare (TCH), and fiber content (FIB) in sugarcane. Moreover, the viability of individual reciprocal recurrent selection (RRSI-S1) was verified, and the effect of inbreeding depression on.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027965
- DOI:
- 10.4238/gmr.15027965
CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population
Authors: Y.M. Guo, Z.C. Zhao, L. Zhang, H.Z. Li, Z. Li and H.L. Sun
The goal of this study was to explore the polymorphisms of CYP2C19 (CYP2C19*2, CYP2C19*3) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) on clopidogrel therapy in Zhengzhou city for guidance on clinical medication and reduction in the incidence of thromboembolic events. Two h.. Read More»
- Genet. Mol. Res. 15(2):
Application of retrograde dissection method for isolation of bone marrow cells from rat femurs and tibiae
Authors: C.M. Li, B.M. Fu, L.C. Zhang, B. Tang, L. Zhu, Y. Zhao and J. Zhang
Currently, there is no practical and efficient method for the isolation of bone marrow cells (BMCs) from rat femurs and tibiae. Here, we attempted to develop a rapid, simple, effective, and non-contaminating method for the isolation of BMCs from rat femurs and tibiae. Rat femurs and tibiae were dissected from the ankle to the .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028178
- DOI:
- 10.4238/gmr.15028178
Relationship between TBX20 gene polymorphism and congenital heart disease
Authors: X.F. Yang, Y.F. Zhang, C.F. Zhao, M.M. Liu, J.P. Si, Y.F. Fang,W.W. Xing and F.L. Wang
Congenital heart disease in children is a type of birth defect. Previous studies have suggested that the transcription factor, TBX20, is involved in the occurrence and development of congenital heart disease in children; however, the specific regulatory mechanisms are yet to be evaluated. Hence, this study aimed to evaluate th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027374
- DOI:
- 10.4238/gmr.15027374
Gene expression and enzyme activity of lipoprotein lipase correlate with intramuscular fat content in Guangxi san-huang and Arbor Acres chickens
Authors: Y.N. Huang, J. Wang, B.J. Chen, Q.Y. Jiang, Y.F. Guo, G.Q. Lan and H.S. Jiang
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. This study investigated LPL gene expression, LPL enzyme activity, and the correlation of each with intramuscular fat (IMF) in Chinese Guangxi san-huang (GXSH) and Arbor Acres (AA) chickens. The results showed that age and breed had significant effects on LPL express.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027414
- DOI:
- 10.4238/gmr.15027414
Translation of foot-and-mouth disease virus RNA: factors influencing alternative AUG selection
Authors: J.L. Liu, Y.H. Ma, J.Y. Xu, Y.X. Chen, S.E. Chen and Z.R. Ma
The mechanism of alternative AUG usage in foot-and-mouth disease virus is not completely understood. Using simple computational approaches, we evaluated the contributions of overall codon bias, quantitative codon bias, and %GC of the region between the two alternative AUGs, Region-La, as well as the nucleotide bias of the sequence context flanking each AU.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.7
- DOI:
- 10.4238/2015.December.14.7
Genetic variation in Rhodomyrtus tomentosa (Kemunting) populations from Malaysia as revealed by inter-simple sequence repeat markers
Authors: T.S. Hue, T.L. Abdullah, N.A.P. Abdullah and U.R. Sinniah
Kemunting (Rhodomyrtus tomentosa) from the Myrtaceae family, is native to Malaysia. It is widely used in traditional medicine to treat various illnesses and possesses significant antibacterial properties. In addition, it has great potential as ornamental in landscape design. Genetic variability studies are important for the rational management and conserv.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.10
- DOI:
- 10.4238/2015.December.14.10
Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia
Authors: A.A. Mansour, O.M. Saleh, T. Askar, A.M. Salim and A. Mergani
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion varia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.13
- DOI:
- 10.4238/2015.December.14.13
Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli
Authors: Y. Yao, Wunier and Morigen
Escherichia coli cells have dozens of two-component systems to sense and respond to various stimuli, and thereby cope with changing environments. BaeS/BaeR is one such two-component system, and it deals with a variety of envelope stresses. Interestingly, the ArcA/ArcB and TorS/TorR two-component systems are known to be associated with initiation of DNA re.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.16
- DOI:
- 10.4238/2015.December.14.16