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Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats
Authors: Y. Wang, G. Huang, B. Mo and C. Wang
The aim of this study was to determine the effect of artesunate on extracellular matrix (ECM) accumulation and the expression of collagen-IV, matrix metalloproteinase (MMP), and tissue inhibitor of matrix metalloproteinase (TIMP) to understand the pharmacological role of artesunate in pulmonary fibrosis. Eighty Sprague-Dawley .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027530
- DOI:
- 10.4238/gmr.15027530
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population
Authors: Q. Xu, P.Y. Gai, H.L. Lv, G.R. Li and X.Y. Liu
Genetic factors may play an important role in frozen shoulder etiology, which may involve matrix metalloproteinase-3 (MMP3) gene polymorphisms. In this study, we examined single nucleotide polymorphisms in MMP3 for their association with frozen shoulder susceptibility in a Chinese Han population. The rs591058, rs650108, and rs679620 polymorphisms in the M.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017228
- DOI:
- 10.4238/gmr.15017228
Association between the PADI4 -94G/A polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population
Authors: H.X. Chang, B. Zhu, J.H. Yao, J. Wu, J. Wang and W. Sun
Although a number of studies have been conducted on the association between the peptidylarginine deiminase (PADI4) -94G/A polymorphism and rheumatoid arthritis (RA) in the Chinese population, the association remains elusive and controversial. To clarify the impact of the PADI4 -94G/A polymorphism on the risk of RA, a meta-analysis was performed in the Chi.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017391
- DOI:
- 10.4238/gmr.15017391
A structured sparse regression method for estimating isoform expression level from multi-sample RNA-seq data
Authors: L. Zhang and X.J. Liu
With the rapid development of next-generation high-throughput sequencing technology, RNA-seq has become a standard and important technique for transcriptome analysis. For multi-sample RNA-seq data, the existing expression estimation methods usually deal with each single-RNA-seq sample, and ignore that the read distributions ar.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027670
- DOI:
- 10.4238/gmr.15027670
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus
Authors: J. Wu, S.S. Hou, W. Wang, M. Yin, N. Cheng, L.L. Ge, J.J. Yin and J. Xu
The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.22
- DOI:
- 10.4238/2015.December.14.22
Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells
Authors: Z.H. Zhang, D.Z. Yin, X.S Pang and Z.C. Wang
Vascular endothelial growth factor (VEGF)-dependent angiogenesis plays a crucial role in corpus luteum formation and its functional maintenance in mammalian ovaries. We recently reported that activation of hypoxia-inducible factor (HIF)-1α signaling contributes to the regulation of VEGF expression in luteal cells (LCs) in response to human chorionic.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.2
- DOI:
- 10.4238/2015.December.14.2
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression
Authors: W.D. Zheng, F.L. Zhou and N. Lin
MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.14
- DOI:
- 10.4238/2015.December.14.14
Serum levels of PSA, ALP, ICTP, and BSP in prostate cancer patients and the significance of ROC curve in the diagnosis of prostate cancer bone metastases
Authors: R.J. Wei, T.Y. Li, X.C. Yang, N. Jia, X.L. Yang and H.B. Song
Bone metastasis is a common complication in prostate cancer patients that can cause bone pain and pathological fracture. This study tested serum levels of prostate specific antigen (PSA), alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) in prostate cancer patients and th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027707
- DOI:
- 10.4238/gmr.15027707
Immunohistochemical subtypes of diffuse large B-cell lymphoma in the head and neck region
Authors: J.M. Li,J. Hou,L. Li and Y. Wang
The objectives of this study were to detect immunohistochemical subtypes of diffuse large B-cell lymphoma (DLBCL) of the head and neck, to compare the Hans, Choi, and Tally algorithms and to examine the significance of protein expression in these algorithms. This study included 103 DLBCL patients at Sichuan Cancer Hospital between May 2010 and October 201.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.3