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Mild hypothermia attenuates post-resuscitation brain injury through a V-ATPase mechanism in a rat model of cardiac arrest
Authors: J.C. Zhang, W. Lu, X.M. Xie, H. Pan, Z.Q. Wu and G.T. Yang
Although therapeutic hypothermia is an effective treatment for post-resuscitation brain injury after cardiac arrest (CA), the underlying mechanism remains unclear. Vacuolar H+-ATPase (V-ATPase) plays a key role in cellular adaption to a hypoxic environment. This study sought to evaluate the effect of mild hypothermia on V-ATPa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027729
- DOI:
- 10.4238/gmr.15027729
An SduI polymorphism at intron 20 of the Chinese Holstein cow STAT4 gene and its effect on milk performance traits
Authors: X.M. Song, L. Zhang, J.F. Jiang, F.X. Shi and Y.Q. Jiang
The signal transducer and activator of transcription (STAT) genes are responsive to a wide range of cytokines, growth factors, and hormones, and thus control important biological processes. In humans, STAT4 mutations have been identified as genetic markers for rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome, w.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.13
- DOI:
- 10.4238/2013.May.13.13
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk
Authors: S. Yan, Y.Z. Li, X.W. Zhu, C.L. Liu, P. Wang and Y.L. Liu
Genetic variations in the caspase genes CASP-3 and CASP-7 are known to be involved in apoptosis, cytokine maturation, cell growth and differentiation. Polymorphisms of CASP-3 and CASP-7 genes have been increasingly recognized as important regulators in the development of cancer. However, whether there is a specific association is still controversial. Ther.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.10
- DOI:
- 10.4238/2013.May.13.10
Co-culture of annulus fibrosus cells and bone marrow mesenchymal stem cells
Authors: Y. Xu,X.J. Zhang,L. Fang and T.B. Zhao
To investigate the effect on cell proliferation and extracellular matrix expression of annulus fibrosus (AF) cells when co-cultured with bone marrow mesenchymal stem cells (BMSCs). Primary isolated rabbit BMSCs and AF cells were cultured and harvested cells were placed into a 15-mL centrifugal tube co-culture system in a ratio of 2:1 (A group), 1:1 (B gro.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.7
CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription
Authors: Z. Su, G. Liu, X. Song, B. Liang, X. Chang and D. Huang
The dehydrogenase/reductase (SDR family) member 4 (DHRS4) gene is copied during mammalian evolution; therefore, while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively. In this study, .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027752
- DOI:
- 10.4238/gmr.15027752
Effect and mechanism of different ways of transplanting bone marrow mesenchymal stem cells in cardiopulmonary resuscitation in rats
Authors: L.L. Zhou, J.K. Liang, Q.M. Lin and Z.T. Huang
The effect and mechanism of different ways of transplanting bone marrow mesenchymal stem cells (MSCs) were explored for treating cardiopulmonary resuscitation in a rat model. Rats were divided into the cardiopulmonary resuscitation group (Group Con), the stereotactic lateral ventricle transplantation group (Group LV), the inte.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.7
- DOI:
- 10.4238/2014.September.29.7
Rapid discrimination between four seagrass species using hybrid analysis
Authors: M. Osathanunkul,P. Madesis,S. Ounjai,C. Suwannapoom and A. Jampeetong
Biological species are traditionally identified based on their morphological features and the correct identification of species is critical in biological studies. However, some plant types, such as seagrass, are taxonomically problematic and difficult to identify. Furthermore, closely related seagrass species, such as Halophila spp, form a taxonomically u.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.10
Genetic structure of Pilosocereus gounellei (Cactaceae) as revealed by AFLP marker to guide proposals for improvement and restoration of degraded areas in Caatinga biome
Authors: E.R. Monteiro, D.K. Strioto, A.C.S. Meirelles, C.A. Mangolin and M.F.P.S. Machado
Amplified fragment length polymorphism (AFLP) analysis was used to evaluate DNA polymorphism in Pilosocereus gounellei with the aim of differentiating samples grown in different Brazilian semiarid regions. Seven primer pairs were used to amplify 703 AFLP markers, of which 700 (99.21%) markers were polymorphic. The percentage of polymorphic markers ranged .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.2
- DOI:
- 10.4238/2015.December.15.2
Association of KCNJ11 with impaired glucose regulation in essential hypertension
Authors: Y. Wang, X.O. Zhou, Y. Zhang, P.J. Gao and D.L. Zhu
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1127
- DOI:
- 10.4238/vol10-2gmr1127
Deep sequencing-based analysis of gene expression in bovine mammary epithelial cells after Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae infection
Authors: L. Xiu, Y.B. Fu, Y. Deng, X.J. Shi, Z.Y. Bian, A. Ruhan and X. Wang
The goal of this study was to characterize the transcriptome of primary bovine mammalian epithelial cells (pBMECs) and to identify candidate genes for response and resistance to Staphylococcus aureus (strain S108), Escherichia coli (strain E23), and Klebsiella pneumoniae (strain K96) infection. Using Solexa sequencing, approximately 4.9 million total sequ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.1
- DOI:
- 10.4238/2015.December.15.1