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Microbial Genetics   Research Article

Effects of acupotomylysis on basic fibroblast growth factor and CD34 levels in rabbits with third lumbar vertebral transverse foramen syndrome

Authors: X.-H. Li, N.-G. Liu, C.-Q. Guo, H.-M. Sun, H.-X. Wu, H. Xu and Y. Zhang

This study observed the local tissue homogenates in rabbits with third lumbar vertebral transverse foramen syndrome and explored the mechanism of acupotomylysis in local tissue revascularization. Thirty Japanese white rabbits were randomly divided into the following 5 groups of 6 rabbits each: normal, model, acupotomy, electroacupuncture (EA), and acupoto.. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.6
DOI:
10.4238/2015.August.19.6
Microbial Genetics   Research Article

Population structure and genetic diversity in Gynaikothrips uzeli (Thysanoptera: Phlaeothripidae): is there a correlation between genetic and geographic proximity?

Authors: A.L.S. Mascarenhas, A.M. Waldschmidt and J.C. Silva Jr.

Gynaikothrips uzeli (Thysanoptera: Phlaeothripidae) is a minuscule insect species, which forms galls, is subsocial, and parthenogenetic. It is associated with Ficus benjamina L. (Moraceae) and has a pantropical occurrence. The paucity of genetic studies on the order Thysanoptera led us to use inter-simple sequence repeat molecular marker to assess intra- .. Read More»

Genet. Mol. Res. 14(3):
2015.August.19.12
DOI:
10.4238/2015.August.19.12
Human Genetics   Research Article

Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population

Authors: L.Y. Wang, P. Zhang, H.F. Wang, Z.W. Qin, K.B. Wei and X.A. Lv

Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in .. Read More»

Genet. Mol. Res. 15(2):
gmr.15026825
DOI:
10.4238/gmr.15026825
Human Genetics   Research Article

Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population

Authors: L. Mao, G.Y. Geng, W.J. Han, M.H. Zhao, L. Wu and H.L. Liu

To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction f.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027803
DOI:
10.4238/gmr.15027803
Microbial Genetics   Research Article

Improving production of extracellular proteases by random mutagenesis and biochemical characterization of a serine protease in Bacillus subtilis S1-4

Authors: X.C. Wang, H.Y. Zhao, G. Liu, X.J. Cheng and H. Feng

The feather is a valuable by-product with a huge annual yield produced by the poultry industry. Degradation of feathers by microorganisms is a prerequisite to utilize this insoluble protein resource. To improve the degrading efficiency of feathers, mutagenesis of the bacterium Bacillus subtilis S1-4 was performed. By combining.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027831
DOI:
10.4238/gmr.15027831
Human Genetics   Research Article

Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

Authors: S.J. Zeng, X.S. Tang, W.L. Zhao, H.X. Qiu, H. Wang and Z.C. Feng

With the advent of antibiotic resistance, pathogenic bacteria have become a major threat in cases of neonatal sepsis; however, guidelines for treatment have not yet been standardized. In this study, 15 cases of neonatal Streptococcus agalactiae sepsis from our hospital were retrospectively analyzed. Of these, nine cases showed.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027962
DOI:
10.4238/gmr.15027962
Human Genetics   Research Article

Association between RNF41 gene c.-206 T > A genetic polymorphism and risk of congenital heart diseases in the Chinese Mongolian population

Authors: Y. Zhang, S.Q. Jin, W.X. Li, G.Q. Gao, K. Zhang and J.L. Huang

This study aimed to explore the association between ring finger protein 41 (RNF41) c.-206 T > A variant and susceptibility to congenital heart disease (CHD) in the Chinese Mongolian population. The association between RNF41 gene c.-206 T > A polymorphism and CHD was examined in two independent case-control studies consis.. Read More»

Genet. Mol. Res. 15(2):
gmr.15028089
DOI:
10.4238/gmr.15028089
Medical Genetics   Research Article

Effect of parasitism of Diatraea saccharalis (Lepidoptera: Crambidae) larvae by the wasp Cotesia flavipes (Hymenoptera: Braconidae) in defense reactions against abiotic agents: production and encapsulation reaction

Authors: C.C.C. Nunes and T.L. Silva

This study aimed to determine prophenoloxidase (proPO) activation and nitric oxide (NO) production in the hemolymph of Diatraea saccharalis larvae non-parasitized and parasitized by the wasp Cotesia flavipes and/or inoculated with abiotic agent (Sephadex beads), during parasitism/inoculation, and related to larval age; the ultrastructure of the capsule fo.. Read More»

Genet. Mol. Res. 12(2):
2013.June.13.7
DOI:
10.4238/2013.June.13.7
Human Genetics   Research Article

Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

Authors: N.I. Hanafi, A.S. Mohamed, J. Md Noor, N. Abdul Hamid Hasani, R. Siran, N.J. Osman, S. Ab Rahim and S.H. Sheikh Abdul Kadir

Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of S.. Read More»

Genet. Mol. Res. 15(2):
gmr.15028150
DOI:
10.4238/gmr.15028150
Human Genetics   Research Article

A systematic review of the intergenerational aspects and the diverse genetic profiles of Huntington�s disease

Authors: L.A. Agostinho, S.R. dos Santos, R.M.P. Alvarenga and C.L.A. Paiva

Huntington’s disease (HD) is a rare progressive and fatal neurogenetic degenerative disease, characterized by movement and personality disorders and by progressive dementia. Its prevalence varies by ethnic origin and different genetic profiles predisposing individuals to HD in each population. The prevalence of HD is 5-10 per 100,000 individuals in .. Read More»

Genet. Mol. Res. 12(2):
2013.June.13.6
DOI:
10.4238/2013.June.13.6