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Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells
Authors: J.Y. Zhang and L.C. Li
Past studies have revealed the critical role of runt-related transcription factor 2 (RUNX2) in the proliferation and differentiation of mesenchymal stem cells (MSCs). This study therefore aimed to investigate the expression profile of the RUNX2 gene in human bone marrow MSCs and its biological characteristics. Bone marrow MSCs were separated from 12 patie.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.8
- DOI:
- 10.4238/2015.December.23.8
Cloning of superoxide dismutase from post-harvest Hami melon and quantitative expression analysis before and after disease
Authors: C.H. Shan, F.X. Tang, W. Chen and W.R. Ma
Primers were designed according to the Cu/Zn-SOD gene sequences of cloned Cucurbits plants (cucumbers and watermelons) available in NCBI. Total RNA from Hami melon pulp was used as a template. Following RT-PCR amplification, a 403-bp fragment of the Hami melon Cu/Zn-SOD gene was obtained. According to alignment in BLAST and phylogenetic tree analysis, the.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.10
- DOI:
- 10.4238/2015.December.23.10
Genetic diversity and structure in natural populations of Maytenus truncata Reiss, 1861, a medicinal plant vulnerable to extractivism in Bahia State, Brazil
Authors: R.R. Simplicio, A.M. Waldschmidt, M.B. Amorim, B.S. Almeida and D.G. Pereira
Maytenus truncata (Celastraceae) is a plant species widely used in the treatment of ulcers and tumors. Despite the intensive harvest of native specimens in the State of Bahia, northeastern Brazil, there is no information about the genetic variability or structure of this species. Therefore, the goal of this study was to estimate the genetic diversity and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.11
- DOI:
- 10.4238/2015.December.23.11
An outbreak of Candida parapsilosis fungemia among preterm infants
Authors: W. Guo, H.F. Gu, H.G. Zhang, S.B. Chen, J.Q. Wang, S.X. Geng, L. Li, P. Liu, X. Liu, Y.R. Ji, S.W. Li and L. Yang
In this article, we describe the first outbreak of Candida parapsilosis fungemia in our hospital. We examined a cluster of four nosocomial cases of C. parapsilosis fungemia that occurred in the neonatal intensive care unit (NICU) of the Affiliated Xingtai People’s Hospital of Hebei Medical University over a two-week period. We ascertained patient pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.13
- DOI:
- 10.4238/2015.December.23.13
Identification of long non-coding RNA involved in osteogenic differentiation from mesenchymal stem cells using RNA-Seq data
Authors: W.Q. Song, W.Q. Gu, Y.B. Qian, X. Ma, Y.J. Mao and W.J. Liu
The aim of this study was to identify long non-coding RNA (lncRNA) associated with osteogenic differentiation from mesenchymal stem cells (MSCs) using high-throughput RNA sequencing (RNA-Seq) data. RNA-Seq dataset was obtained from the European Bioinformatics Institute (accession No. PRJEB4496), including two replicates each for immortalized mesenchymal s.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.14
- DOI:
- 10.4238/2015.December.23.14
De novo assembly, functional annotation, and marker development of Asian pear (Pyrus pyrifolia) fruit transcriptome through massively parallel sequencing
Authors: J.F. Li, Z. Gao, Y.S. Lou, M. Luo, S.R. Song, W.P. Xu, S.P. Wang and C.X. Zhang
This study investigated the Asian pear transcriptome using the RNA-Seq normalized fruit cDNA library to create a transcriptomic resource for unigene and marker discovery. Following the removal of lowquality reads, 127,085,054 trimmed reads were assembled de novo to yield 37,649 non-redundant unigenes with an average length of 599 bp. Alternative splicing .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.22
- DOI:
- 10.4238/2015.December.23.22
Comparison of high-intensity focused ultrasound therapy under nasal endoscopy guidance versus first-line drug treatment in patients with persistent allergic rhinitis
Authors: G.F. Feng, Z.L. Han, F. Wang, B.C. Sun, Z.Y. Dai, S.Z. Yang and C.Y. Zhou
The aim of this study was to determine whether high-intensity focused ultrasound (HIFU) therapy under nasal endoscopy guidance could provide better efficacy and safety in patients with persistent allergic rhinitis (PAR) than the first-line drugs recommended by the World Health Organization. A total of 120 adult patients with PAR were randomly divided into.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.20
- DOI:
- 10.4238/2015.August.19.20
Heat shock protein 70 polymorphisms in Chinese patients with Graves� disease
Authors: Y.P. Wang, Z. Tang, B.K. Peng,Q. Zhen, S.L. Zhou and X.F. Jin
Graves’ disease (GD) is a common autoimmune disease mainly affecting the thyroid. However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population. Therefore, the aim of this study was to investigate the association between HSP70 polymorphisms and GD in the Chinese population. A total of 153 pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.25
- DOI:
- 10.4238/2015.December.23.25
Segregation analysis of microsatellite (SSR) markers in sugarcane polyploids
Authors: X. Lu, H. Zhou, Y.-B. Pan, C.Y. Chen, J.R. Zhu, P.H. Chen, Y.-R. Li, Q. Cai and R.K. Chen
No information is available on segregation analysis of DNA markers involving both pollen and self-progeny. Therefore, we used capillary electrophoresis- and fluorescence-based DNA fingerprinting together with single pollen collection and polymerase chain reaction (PCR) to investigate simple sequence repeat (SSR) marker segregation among 964 single pollens.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.26
- DOI:
- 10.4238/2015.December.23.26
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis
Authors: L.L. Zhang, Y.Q. Wang, B. Fu, S.L. Zhao and Y. Kui
We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.38
- DOI:
- 10.4238/2015.December.23.38