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PPAR�³ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimerâ��s disease: a meta-analysis
Authors: Y.H. Lee and G.G. Song
We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferatoractivated receptor gamma (PPARg) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a metaanalysis of the associations between the PPARg Pro12Ala and His447His polymorphisms and AD in subjects. The meta-anal.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.18
- DOI:
- 10.4238/2015.June.29.18
Malondialdehyde and SOD-induced changes of gastric tissues in acute gastric mucosal injury under positive acceleration
Authors: J. Li, H.L. Tang, Y. Chen, Q. Fan, Y.T. Shao, M. Jia, J.C. Wang and C.M. Yang
The aim of this study was to investigate the impacts of positive acceleration (+Gz) on the gastric mucosal tissues in cases of acute gastric mucosal injury and to explore the role of oxygen free radicals. Thirty Sprague Dawley rats were randomly divided into the absolute ethanol control group (A group), absolute et.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.9
Ion beam transformation with corn DNA alters proteinase expression in rice seedling roots
Authors: W.C. Li, S.D. Ji, X.C. Wang, Z.K. Li, H.C. Zhang, C.Z. Tian,Y.L. Liuand C.X. Duan
Corn DNA was introduced into dry seeds of rice (cv. ‘YuJing-6’) by ion beam irradiation. Proteinase activities in rice seedling roots were subsequently analyzed by renaturation electrophoresis at pH 4.5, 7.0, and 8.5. Proteinase activity was more pronounced on gels at higher pH. Irradiation of r.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.19
- DOI:
- 10.4238/2015.June.29.19
The olfactory receptor universe - from whole genome analysis to structure and evolution
Authors: Tsviya Olender, Ester Feldmesser, Tal Atarot, Miriam Eisenstein and Doron Lancet
Olfactory receptors (ORs) constitute the largest gene-family in the vertebrate genome. We have attempted to provide a comprehensive view of the OR universe through diverse tools of bioinformatics and computational biology. Among others, we have constructed the Human Olfactory Receptor Data Exploratorium (HORDE, http://bioporta.. Read More»
- Genet. Mol. Res. 3(4):
A bioinformatics analysis of alternative exon usage in human genes coding for extracellular matrix proteins
Authors: Noboru Jo Sakabe, Maria Dulcetti Vibranovski and Sandro Jos�© de Souza
Alternative splicing increases protein diversity through the generation of different mRNA molecules from the same gene. Although alternative splicing seems to be a widespread phenomenon in the human transcriptome, it is possible that different subgroups of genes present different patterns, related to their biological roles. An.. Read More»
- Genet. Mol. Res. 3(4):
Identification and complete sequencing of novel human transcripts through the use of mouse orthologs and testis cDNA sequences
Authors: Elisa N. Ferreira, Lilian C. Pires, Raphael B. Parmigiani,Fabiana Bettoni, Renato D. Puga, Daniel G. Pinheiro,LuÃ?Âs Eduardo C. Andrade, Luciana O. Cruz, Theri L. Degaki,Milton Faria Jr., Fernanda Festa, Daniel Giannella-Neto,Ricardo R. Giorgi, Gustavo H. Goldman, Fabiana Granja,Arthur Gruber, Christine Hackel, FlÃ?¡vio Henrique-Silva,Bettina Malnic, Carina V.B. Manzini, Suely K.N. Marie14,Nilce M. Martinez-Rossi15, Sueli M. Oba-Shinjo14,Maria Ines M.C. Pardini16, Paula Rahal18, ClÃ?¡udia A.Rainho,Silvia R. Rogatto, Camila M. Romano, Vanderlei Rodrigues,Magaly M. Sales, Marcela Savoldi8, Ismael D.C.G. da Silva,Neusa P. da Silva, Sandro J. de Souza, Eloiza H. Tajara,Wilson A. Silva Jr, Andrew J.G. Simpson, Mari C. Sogayar,Anamaria A. Camargo and Dirce M. Carraro
The correct identification of all human genes, and their derived transcripts, has not yet been achieved, and it remains one of the major aims of the worldwide genomics community. Computational programs suggest the existence of 30,000 to 40,000 human genes. However, definitive gene identification can only be achieved by experim.. Read More»
- Genet. Mol. Res. 3(4):
Evaluation of window cohabitation of DNA sequencing errors and lowest PHRED quality values
Authors: Francisco Prosdocimi, Fabiano Cruz Peixoto and Jos�© Miguel Ortega
When analyzing sequencing reads, it is important to distinguish between putative correct and wrong bases. An open question is how a PHRED quality value is capable of identifying the miscalled bases and if there is a quality cutoff that allows mapping of most errors. Considering the fact that a low quality value does not necess.. Read More»
- Genet. Mol. Res. 3(4):
VSQual: a visual system to assist DNA sequencing quality control
Authors: Eliseu Binneck, Jo�£o Fl�¡vio V. Silva, Norman Neumaier,Jos�© Renato B. Farias and Alexandre L. Nepomuceno
A lack of pliant software tools that support small- to medium-scale DNA sequencing efforts is a major hindrance for recording and using laboratory workflow information to monitor the overall quality of data production. Here we describe VSQual, a set of Perl programs intended to provide simple and powerful tools to check severa.. Read More»
- Genet. Mol. Res. 3(4):
Comparative analysis of noncoding sequences of orthologous bovine and human gene pairs
Authors: Melissa Nunes Miziara, Penny K. Riggs and M. Elisabete J. Amaral
Genomic sequence comparison across species has enabled the elucidation of important coding and regulatory sequences encoded within DNA. Of particular interest are the noncoding regulatory sequences, which influence gene transcriptional and posttranscriptional processes. A phylogenetic footprinting strategy was employed to iden.. Read More»
- Genet. Mol. Res. 3(4):
Easy detection of green fluorescent proteinmulticopy transformants in Penicillium griseoroseum
Authors: Francis J.F. Lopes, Elza F. de Ara�ºjo and Marisa V. de Queiroz
Penicillium griseoroseum, a deuteromycete fungus producer of pectinolytic enzymes, was transformed with a gene encoding for green fluorescent protein (GFP). The selection of transformants was based on the homologous nitrate reductase gene (niaD). Protoplasts of a P. griseoroseum Nia mutant (PG63) were co-transformed with the p.. Read More»
- Genet. Mol. Res. 3(4):