Single Nucleotide Polymorphisms
Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Authors: G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In a.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039697
- DOI:
- 10.4238/gmr16039697
Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand
Authors: A. Tungtrongchitr, J. Jumpasri, N. Sookrung, N. Visitsunthorn, P. Tantilipikorn, O. Piboonpocanan, N. Indrawattana, R. Tungtrongchitr and W. Chaicumpa
Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled st.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039641
- DOI:
- 10.4238/gmr16039641
Adjacent SNPs in the transcriptional regulatory region of the FADS2 gene associated with fatty acid and growth traits in chickens
Authors: S.K. Zhu, Y.D. Tian, S. Zhang, Q.X. Chen, Q.Y.Wang,R.L. Han and X.T. Kang
Delta-6 fatty acid desaturases are rate-limiting desaturases involved in metabolic processes of fatty acids, and they are encoded by the FADS2 gene. In the current study, an F2 resource population of Gushi chickens crossed with Anak broilers was used to investigate the genetic effects of the chicken FADS2. Two adjacent single .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.11
- DOI:
- 10.4238/2014.April.29.11
Interleukin-7 receptor gene polymorphism at +1237 locus and its effect on susceptibility to opportunistic infections among HIV and AIDS patients in Limpopo Province, South Africa
Authors: A. Samie, G.T. Moloro and T.C. Nangammbi
Over the past decade, an increasing number of studies have demonstrated correlations between host genetics and susceptibility to diseases. However, few studies have investigated the effects of host genetics on the occurrence of opportunistic infections among human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) patients. In the .. Read More»
- Genet. Mol. Res. 13(4):
Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature
Authors: Y. Yang, H. Huang,W. Wang, L. Yang, L.L. Xie and W. Huang
The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyp.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.18.14
- DOI:
- 10.4238/2013.October.18.14
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility
Authors: L.P. Ren, Y.S. Xian, D.M. Diao, Y. Chen, Q. Guo and C.X. Dang
BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucl.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.6
- DOI:
- 10.4238/2013.November.22.6
Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis
Authors: C.C. Guo, W.H. Huang, N. Zhang, F. Dong, L.P. Jing, Y. Liu, X.G. Ye, D. Xiao, M.L. Ou, B.H. Zhang, M. Wang, W.K. Liang, G. Yang and C.X. Jing
Celiac disease (CD) is a common autoimmune disorder characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear. We performed a meta-analysis of the associations between rs6822844, rs6840.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.19
- DOI:
- 10.4238/2015.October.26.19
Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle
Authors: A.B. Grisolia1,2, G.T. D��?Angelo1, L.R. Porto Neto1, F. Siqueira3 andJ.F. Garcia1
The myostatin gene, also known as GDF8 (growth differentiation factor 8), is located on bovine chromosome 2 (BTA2); it has three exons and two introns. Myostatin is specifically expressed during embryonic development and in adult skeletal muscle, functioning as a negative regulatory protein. Several cattle breeds (Piedmontese, Belgian Blue .. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr548
- DOI:
- 10.4238/vol8-3gmr548
Single nucleotide polymorphisms from Theobroma cacao expressed sequence tags associated with witches��? broom disease in cacao
Authors: L.S. Lima1, K.P. Gramacho1, N. Carels2, R. Novais1, F.A. Gaiotto2,U.V. Lopes1, A.S. Gesteira2, H.A. Zaidan1,2, J.C.M. Cascardo2,J.L. Pires1 and F. Micheli2,3
In order to increase the efficiency of cacao tree resistance to witches’ broom disease, which is caused by Moniliophthora perniciosa (Tricholomataceae), we looked for molecular markers that could help in the selection of resistant cacao genotypes. Among the different markers useful for developing marker-assisted selection, single nucleotide polymorp.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr603
- DOI:
- 10.4238/vol8-3gmr603
XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people
Authors: X. Wang, K.W. Ma, Y.G. Zhao, G.J. Wang, W. Li
Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nucleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.3
- DOI:
- 10.4238/2015.December.1.3