Single Nucleotide Polymorphisms
Polymorphism analysis of the intron one of insulin-like growth factor 2 receptor gene (IGF2R) in FFRC strain common carp (Cyprinus carpio L.) and its relationship with growth performance
Authors: Z.J. Dong, S.Y. Su, W.B. Zhu, C.F. Zhang, M. Ding, W.X. Chen, X.H. Yuan and Z. Xie
The insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor and acts to sequester and degrade excess circulating insulin-like growth factor 2, which is critical for normal mammalian growth and development. Thus, IGF2R may serve as a candidate gene underlying growth trait in the common carp. In this study, we isolated th.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.23.14
- DOI:
- 10.4238/2015.January.23.14
Development and characterization of single nucleotide polymorphism markers in Camellia sinensis (Theaceae)
Authors: C.C. Zhang, L.Y. Wang, K. Wei and H. Cheng
Tea is the second most popular non-alcoholic beverage in the world. In recent years, several molecular markers have been used in genetic studies of the tea plant. Yet, only a few single nucleotide polymorphisms (SNPs) have been reported. Here, we identified 818 putative SNPs from expressed sequence tag (EST) databases for the .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.April.14.10
- DOI:
- 10.4238/2014.April.14.10
Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome
Authors: L. Wei, Y. An and J. Wang
Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038401
- DOI:
- 10.4238/gmr.15038401
Two novel SNPs of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene associated with growth and meat quality traits in the chicken
Authors: Y. Wei S.K. Zhu S. Zhang R.L. Han Y.D. Tian G.R. Sun X.T. Kang
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is rate-limiting for metabolism of cholesterol; it plays an important role in endogenous cholesterol biosynthesis. We used DNA sequencing technology and created restriction site PCR-RFLP to detect HMGCR SNPs in an F2 resource population of Gushi chicken and Anka broilers. We found a G/T mu.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.10
- DOI:
- 10.4238/2012.November.12.10
Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma
Authors: J.Y. Wang, A.L. Wang, W. Han, Z.L. Mu
Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and modulates the function of other neurotransmitters. Allergic inflammation triggers neuronal dysfunction and structural changes in the airways. Genetic polymorphisms in functional regions of the BDNF gene have a plausible role in modulating the risk of chi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.13
- DOI:
- 10.4238/2015.December.8.13
Single nucleotide polymorphisms in Brahman steers and their association with carcass and tenderness traits
Authors: T. Smith M.G. Thomas T.D. Bidner J.C. Paschal D.E. Franke
Data from purebred Brahman steers (N = 467) were used to study the association of single nucleotide polymorphisms (SNP) with carcass traits and measures of tenderness. Fall weaned calves were grazed and fed in a subtropical environment and then harvested for processing in a commercial facility. Carcass data were recorded 24 h .. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr537
- DOI:
- 10.4238/vol8-1gmr537
Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia
Authors: Y. Mu Z. Xu C.I. Contreras J.S. McDaniel K.J. Donly S. Chen
Both BMP2 and BMP4 are involved in tooth development. We examined phenotypes and BMP2 and BMP4 gene variations in two Mexican oligodontia families. Physical and oral examinations and panoramic radiographs were performed on affected and unaffected members in these two families. The affected members lacked six or more teeth. DNA sequencing was performed to .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.September.25.5
- DOI:
- 10.4238/2012.September.25.5
Association of TUSC3 gene polymorphisms with non-syndromic mental retardation based on nuclear families in the Qinba mountain area of China
Authors: M.J. Zhang, L.X. Xing, M. Cui, X. Yang, J.G. Shi, J. Li, K.J. Zhang, Z.J. Zheng, F.C. Zhang, J.L. Li and X.C. Gao1,3
TUSC3 interacts with the protein phosphatase 1 and magnesium ion transport system, which plays an important role in learning and memory. Abnormal conditions of learning and memory are common clinical characteristics of mental retardation (MR). However, the association of TUSC3 genetic polymorphisms with MR remains unknown. A total of 456 DNA samples inclu.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.5
- DOI:
- 10.4238/2015.May.12.5
Association of NF-�ºB1 gene polymorphisms with coronary artery disease in a Han Chinese population
Authors: X.L. Guo, X.C. Liu, G.B. Su, C.Y. Zhou and Q.T. Cui
Nuclear factor (NF)-κB is a transcription factor that controls cell proliferation, differentiation, and immunity. Activated NF-κB1 is associated with the pathogenesis of coronary artery disease (CAD) and genetic polymorphisms in NF-κB1 have a plausible role in modulating the risk of CAD. To identify markers that contribute to the genetic.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038072
- DOI:
- 10.4238/gmr.15038072
Association study between single nucleotide polymorphisms in leptin and growth traits in Cyprinus carpio var. Jian
Authors: Y. Tang, H. Li, J. Li, F. Yu and J. Yu
Leptin is a hormone that affects the regulation of body weight, energy expenditure, fat metabolism, food intake, and appetite. In this study, we cloned the jlLEP-A1 and jlLEP-A2 genes in Jian carp (Cyprinus carpio var. Jian) and performed an association analysis between identified polymorphisms and growth traits. Three polymorphisms in exons of jlLEP-A1 (.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037635
- DOI:
- 10.4238/gmr.15037635