Single Nucleotide Polymorphisms
Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population
Authors: W.F. Xia, X.P. Ma, X.R. Li, H. Dong and J.L. Yi
XRCC1 (human X-ray repair complementing defective repair in Chinese hamster cell 1) gene is considered a potentially important gene influencing the risk of hepatocellular carcinoma (HCC). Our analyses detected two allelic variants of XRCC1, c.910A>G and c.1686C>G. We aimed to investigate whether these polymorphisms influ.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.28.3
- DOI:
- http://dx.doi.org/10.4238/2014.February.28.3
FSHR gene Thr307Ala and Asn680Ser polymorphisms in infertile men: an association study in North China and meta-analysis
Authors: X.Q. Wu, S.M. Xu, Y.Q. Wang, Q. Li, Z.Q. Wang, C.L. Zhang and Y. Shen
Male infertility is a complex multifactorial and polygenic disease, and genetic factors play an important role in its formation and development. Recently, the association between follicle stimulating hormone receptor (FSHR) gene polymorphisms and male infertility risk has attracted widespread attention due to the unique biological functions of FSH. The ai.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.11
- DOI:
- 10.4238/2015.May.25.11
Polymorphisms in a myostatin gene and associations with growth in a hybrid of Culter alburnus and Ancherythroculter nigrocauda
Authors: L. Cheng and Y.H. Sun
Myostatin (MSTN) is a member of the transforming growth factor-β superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in a hybrid of Culter alburnus (ΓΆΒ?Β?) x Ancherythroculter nigrocauda (ΓΆΒ?Β?) individuals from.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.25.13
- DOI:
- 10.4238/2015.May.25.13
Genome-wide polymorphisms between the parents of an elite hybrid rice and the development of a novel set of PCR-based InDel markers
Authors: K. Wang, J.Y. Zhuang, D.R. Huang, J.Z. Ying and Y.Y. Fan
Genome-wide re-sequencing of the Zhenshan 97 (ZS97) and Milyang 46 (MY46) parents of an elite three-line hybrid rice developed in China resulted in the generation of 9.91 G bases of data with an effective sequencing depth of 11.66x and 11.51x, respectively. Detection of genome-wide DNA polymorphisms, single nucleotide polymorphisms (SNPs), short insertion.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.10.33
- DOI:
- http://dx.doi.org/10.4238/2015.April.10.33
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929
Association between interleukin-17A polymorphism and coronary artery disease susceptibility in the Chinese Han population
Authors: G.B. Su, X.L. Guo, X.C. Liu, Q.T. Cui and C.Y. Zhou
Coronary artery disease (CAD) is a major global health problem. In China, the incidence of CAD and the rate of mortality arising from it have increased every year. Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by activated T cells, and it may be involved in the development of CAD. Genetic polymorphisms in functional regions of the IL17A .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038235
- DOI:
- 10.4238/gmr.15038235
Association between a non-synonymous HSD17B4 single nucleotide polymorphism and meat-quality traits in Berkshire pigs
Authors: J.L. Jo, J.H. Hwang, S.G. Kwon, D.H. Park, T.W. Kim, D.G. Kang, G.E. Yu, I.S. Kim, J. Ha and C.W. Kim
Single nucleotide polymorphisms (SNPs) are useful genetic markers that allow correlation of genetic sequences with phenotypic traits. It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during β-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:12.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048970
- DOI:
- 10.4238/gmr15048970
Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer
Authors: W.X. Hu, C.M. Ding, R.J. Li, H.Y. Fan, Z.J. Guo and W. Liu
The associations between single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) and cancer risk and disease outcome have been extensively analyzed. We investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of non-small cell lung cancer (NSCLC) pa.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.9
Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer
Authors: L.P. Chen, P.S. Cai and H.B. Liang
Nuclear factor-kB (NF-kB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-kB gene family) is associated with increased risk of various cancers. However, only one study ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.15
- DOI:
- 10.4238/2015.July.27.15
Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population
Authors: F.F. Yang Y. Huang Q.B. Li J.H. Dai Z. Fu
Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma. We investigated genetic associations of SNPs in and around the ORMDL3 gene with childhood asthma in a Chinese population. Genomic DNA was extracted f.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.19.1
- DOI:
- 10.4238/2012.October.19.1