Single Nucleotide Polymorphisms
Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women
Authors: J.F. Song, Z.Z. Jing, W. Hu and Y.X. Su
Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteo.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.3.4
- DOI:
- 10.4238/2013.September.3.4
Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic �²-cell function in gestational diabetes mellitus
Authors: Y. Zhan, C. Li, Q. Gao, J. Chen, S. Yu and S.G. Liu
We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were de.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.1
- DOI:
- 10.4238/2015.August.3.1
Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction
Authors: B. Yuan and J.F. Teng
We examined the association between the adiponectin receptor 2 gene and the risk of ischemic stroke. Polymerase chain reaction-restriction fragment length polymorphism was used to detect rs12342 genotypes of the adiponectin receptor 2 gene in 300 ischemic stroke patients and 320 age- and gender-matched healthy controls. In the.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.19
- DOI:
- 10.4238/2014.September.26.19
CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China
Authors: C.-P. Liu, J.-A. Jiang, T. Wang, X.-M. Liu, L. Gao, R.-R. Zhu, Y. Shen, M. Wu, T. Xu and X.-G. Zhang
The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.8
- DOI:
- 10.4238/2013.April.25.8
Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis
Authors: A.E. Osman, M. Mubasher, N.E. ElSheikh, H. AlHarthi, I.A. AlAlallah, A.A. Elbeshir, M. Abashar, N. Elsidig, G. ElGhazali and A.-S.A. Fadil
Osteomyelitis is a progressive bone infection disease caused by destructive immunological inflammatory reactions following new bone formation. Anti-inflammatory cytokines are a series of immunoregulatory molecules that control the pro-inflammatory cytokine response. In this study, we investigated 9 single nucleotide polymorphisms in 5 different cytokine/c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.15.4
- DOI:
- 10.4238/2015.December.15.4
Association between NOS3 genetic variants and coronary artery disease in the Han population
Authors: G.L. Zhao, Q.J. Li and H.Y. Lu
The enzyme endothelial nitric oxide synthase (NOS3) is an important mediator of atherosclerotic disease and is associated with coronary artery disease (CAD). There is growing evidence that polymorphisms in NOS3 influence the progression of CAD; however, there is also a controversy regarding the association of polymorphisms in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028044
- DOI:
- 10.4238/gmr.15028044
Association study between matrix metalloproteinase-9 gene (MMP9) polymorphisms and the risk of Henoch-Sch�¶nlein purpura in children
Authors: E.D. Xu, Y.F. Xiao, J.J. Wang and L. Dong
Henoch-Schönlein purpura nephritis (HSPN), the most serious long-term complication of Henoch-Schönlein purpura, is one of the most common renal diseases in children. Matrix metalloproteinase-9 (MMP-9) is implicated in the pathogenesis of renal diseases. Genomic DNA was isolated from the venous blood leukocytes of 220.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028095
- DOI:
- 10.4238/gmr.15028095
Associations between HIF-1�± polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease
Authors: W.T. Wei, B. Li, M. Chen, H.R. Jia and H.X. Zhang
In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.2
- DOI:
- 10.4238/2015.December.21.2
Vascular endothelial growth factor gene is associated with hypertensive cerebellar hemorrhage and rehabilitative treatment
Authors: Q.S. He, L.F. Yang, W.B. Wang, B. Yuan, L.Y. Zhang and X.J. Guo
Early rehabilitative therapy is important for patients with hypertensive cerebral hemorrhage to improve long-term function of the extremities. Vascular endothelial growth factor (VEGF) is closely associated with the pathogenesis of hypertension. To identify the markers contributing to the genetic susceptibility to hypertensive cerebellar hemorrhage (HCH) .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.18
- DOI:
- 10.4238/2015.August.19.18
APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease
Authors: Y. Sun, R.B. Zhou and D.M. Chen
The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to thes.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.9
- DOI:
- 10.4238/2015.December.23.9