Snp
Association of ATP1A1 gene polymorphism with heat tolerance traits in dairy cattle
Authors: Y.X. Liu, X. Zhou, D.Q. Li, Q.W. Cui and G.L. Wang
Heat stress produces oxidative stress and affects the alternation of plasma K+ and Na+. Since Na+,K+-ATPase is sensitive to oxidative stress and critical for maintaining the homeostasis of these two ions, we examined the genetic polymorphism of the ATP1A1 gene in 160 Holstein cows using polymerase chain reaction low ionic stre.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr769
- DOI:
- 10.4238/vol9-2gmr769
Polymorphisms in the IGF1 gene and their effect on growth traits in Mexican beef cattle
Authors: X.F. De la Rosa Reyna, H.M. Montoya, V.V. Castrell?³n, A.M.S. Rinc?³n, M.P. Bracamonte and W.A. Vera
The IGF1 gene (insulin-like growth factor 1) is a candidate gene for marker-assisted selection strategies. A single nucleotide polymorphism in the promoter region (IGF1/SnaBI) has been reported to be associated with production traits in several cattle breeds. Here, we report its allelic frequencies in Charolais and Beefmaster .. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr745
- DOI:
- 10.4238/vol9-2gmr745
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Authors: A. Sanz, L. Ordov?¡s, C. Serrano, P. Zaragoza, J. Altarriba and C. Rodellar
The bovine transferrin gene (TF) is located at 125 cM on bovine chromosome 1 (BTA1); it codes for transferrin, a glycoprotein that is highly conserved in many species and that is responsible for iron transport. The TF gene has been located in several QTL regions, and some transferrin classes have been associated with fat and m.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr784
- DOI:
- 10.4238/vol9-2gmr784
Mining SNPs from EST sequences using filters and ensemble classifiers
Authors: J. Wang, Q. Zou and M.Z. Guo
Abundant single nucleotide polymorphisms (SNPs) provide the most complete information for genome-wide association studies. However, due to the bottleneck of manual discovery of putative SNPs and the inaccessibility of the original sequencing reads, it is essential to develop a more efficient and accurate computational method f.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr765
- DOI:
- 10.4238/vol9-2gmr765
CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico
Authors: I.V. Rom?¡n-Fern?¡ndez, D.F. ?vila-Castillo, S. Cerpa-Cruz,S. Guti?©rrez-Ure?±a, J. Hern?¡ndez-Bello, J.R. Padilla-Guti?©rrez, Y. Valle, M.G. Ram?rez-Due?±as, A.L. Pereira-Su?¡rez and J.F. Mu?±oz-Valle
The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048775
- DOI:
- 10.4238/gmr15048775
TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese
Authors: X.M. Xu, M. Ding, H. Pang and B.J. Wang
In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nu.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.1
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.1
Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis
Authors: J. De Azevedo Silva, S.C. Lima, C. Addobbati, R. Moura, L.A. Cavalcanti Brand?£o, J.A. Tr?©s Pancoto, E.A. Donadi, S. Crovella and P. Sandrin-Garcia
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral toler.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048008
- DOI:
- 10.4238/gmr15048008
Development of coding single nucleotide polymorphic markers in the pearl oyster Pinctada fucata based on next-generation sequencing and high-resolution melting analysis
Authors: S.G. Fan, J.F. Wei, Y.H. Guo, G.J. Huang and D.H. Yu
The pearl oyster Pinctada fucata is an important commercial marine shellfish that is cultured for producing saltwater pearls. In this study, 468 single nucleotide polymorphisms (SNPs) were screened from P. fucata transcriptome data, and 119 polymorphic SNPs were successfully isolated by a two-step small-amplicon high-resolutio.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049054
- DOI:
- 10.4238/gmr15049054
Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese
Authors: Y. Zhao, M. Ding, H. Pang, X.M. Xu and B.J. Wang
Dopamine (DA) has been implicated in the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopamine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.March.12.13
- DOI:
- http://dx.doi.org/10.4238/2014.March.12.13
Single nucleotide polymorphism analysis of exons 3 and 4 of IGF-1 gene in pigs
Authors: L.L. Hao, H. Yu, Y. Zhang, S.C. Sun, S.C. Liu, Y.Z. Zeng, Y.X. Ai and H.Z. Jiang
The IGF-1 gene has been implicated as a candidate gene for the regulation of pig growth traits. We analyzed exons 3 and 4 of IGF-1 gene polymorphisms of the Banna mini-pig (28), the Tibetan mini-pig (30), the Junmu pig (55), and L. Yorkshire species (50) using PCR-SSCP. Three genotypes in exon 3 and 6 genotypes in exon 4 were .. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr1328
- DOI:
- 10.4238/vol10-3gmr1328