Snp
Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma
Authors: X.F. Chen, S. Cai, Q.G. Chen, Z.H. Ni, J.H. Tang, D.W. Xu and X.B. Wang
Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.16.2
- DOI:
- 10.4238/2012.February.16.2
Polymorphism of somatostatin gene and its association with growth traits in Chinese cattle
Authors: L. Gao, L.S. Zan, H.B. Wang, R.J. Hao and X. Zhong
Somatostatins play a crucial role in the regulation of growth and development in vertebrates, especially muscle growth. We assessed the association of somatostatin gene polymorphisms with growth traits by PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism) and DNA sequencing methods in 694 individuals .. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1029
- DOI:
- 10.4238/vol10-2gmr1029
Polymorphisms of the cocaine-amphetamine-regulated transcript (CART) gene and their association with reproductive traits in Chinese goats
Authors: P.Q. Wang, L.M. Deng, B.Y. Zhang, M.X. Chu and J.Z. Hou
Polymorphisms of the CART gene were investigated by PCR-single-strand conformation polymorphism analysis in 540 samples from 10 goat breeds. Ten novel single-nucleotide polymorphisms as well as three microsatellites were detected; a mutation, 77T→C, led to an amino acid change (Leu→Ser). Associations between polymorp.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr1091
- DOI:
- 10.4238/vol10-2gmr1091
A novel polymorphism of the GDF10 gene and its association with body measurement traits in Chinese indigenous cattle
Authors: C. Adoligbe, L.S. Zan, H.B. Wang and J.A. Ujjan
Body measurement traits are known to play numerous important roles in the assessment of productivity and economic value. They are influenced by several factors, among which genetic factors are predominant. The gene GDF10 is involved in skeletal morphogenesis and is associated with body measurement traits. It may be an importan.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr989
- DOI:
- 10.4238/vol10-2gmr989
Correlation analysis between single nucleotide polymorphism of DRD1 gene and stereotyped behavior of blue fox
Authors: Z.Y. Liu, E.J. Ren, H.X. Ba, Q. Wu, H.W. Zhu, X.M. Xing and F.H. Yang
This study was performed to investigate the correlation between stereotyped behavior of the blue fox and single nucleotide polymorphisms (SNPs) of the DRD1 gene. We choose the DRD1 gene as a major gene for investigating the correlation of gene polymorphism and self-biting disease by means of direct sequencing. Part of the DRD1 gene exon of the blue fox wa.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.8.1
- DOI:
- 10.4238/2015.June.8.1
Polymorphisms of the ATP1A1 gene associated with mastitis in dairy cattle
Authors: Y.X. Liu, C.H. Xu, T.Y. Gao and Y. Sun
Mastitis affects the concentrations of potassium and sodium in milk. Since sodium-potassium adenosine triphosphatase (Na+, K+-ATPase) is critical for maintaining the homeostasis of these two ions, and is involved in cell apoptosis and pathogenesis, we presumed that polymorphism of the ATP1A1 gene, which encodes the bovine Na+,.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.16.3
- DOI:
- 10.4238/2012.March.16.3
BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population
Authors: H.C. Loh, P.Y. Tang, S.F. Tee, T.J. Chow, Y.C. Cheah and S.S.J. Singh
A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.22.2
- DOI:
- 10.4238/2012.March.22.2
Polymorphisms in the leptin gene promoter in Brazilian beef herds
Authors: R.C. Guimar�£es, J.S.N. Azevedo, S.C. Corr�ªa, J.E.G. Campelo, E.M. Barbosa, E.C. Gon�§alves and E. Silva Filho
Brazil is the world’s largest producer of beef cattle; however, the quality of its herds needs to be improved. The use of molecular markers as auxiliary tools in selecting animals for reproduction with high pattern for beef production would significantly improve the quality of the final beef product in Brazil. The leptin.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048981
- DOI:
- 10.4238/gmr15048981
Polymorphism of starch pathway genes in cassava
Authors: L.M. Vasconcelos, A.C. Brito, C.D. Carmo and E.J. Oliveira
The distribution and frequency of single nucleotide polymorphisms (SNPs) can help to understand changes associated with characteristics of interest. We aimed to evaluate nucleotide diversity in six genes involved in starch biosynthesis in cassava using a panel of 96 unrelated accessions. The genes were sequenced, aligned, and .. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049082
- DOI:
- 10.4238/gmr15049082
Novel single nucleotide polymorphisms in the 5' regulatory region of the duck SCD1 gene and their associations with serum biochemical levels and fatty acid composition
Authors: W.-G. Li, Y.-Y. Zhang and D.-D. Wang
Stearoyl-coenzyme A desaturase 1 (SCD1) is the key limiting enzyme in the synthesis of monounsaturated fatty acids, and plays a crucial role in the regulation of oleic acid. In this study, 165 ten-week-old Cherry Valley ducks were used to investigate single nucleotide polymorphisms (SNPs) in the 5' regulatory region of the SCD.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039007
- DOI:
- 10.4238/gmr.15039007