Snp
Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle
Authors: N. HernÃ?¡ndez, J.C. MartÃ?Ânez-GonzÃ?¡lez, G.M. Parra-Bracamonte, A.M. Sifuentes-RincÃ?³n, N. LÃ?³pez-Villalobos, S.T. Morris, F. Briones-Encinia, E. Ortega-Rivas, V.I. Pacheco-Contreras and L.A. Meza-GarcÃ?Âa
Polymorphisms in candidate genes can produce significant and favorable changes in the phenotype, and therefore are useful for the identification of the best combination of favorable variantsfor marker-assisted selection. In the present study, an assessment to evaluate the effect of 11 single nucleotide polymorphisms (SNPs) in .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038449
- DOI:
- 10.4238/gmr.15038449
Association of novel single nucleotide polymorphisms of the CXCR1 gene with the milk performance traits of Chinese native cattle
Authors: L. Zhou, H.M. Wang, Z.H. Ju, Y. Zhang, J.M. Huang, C. Qi, M.H. Hou, L.G. An, J.F. Zhong and C.F. Wang
Mastitis is an economically devastating disease affecting the dairy industry. Dairy cows with mastitis give reduced milk yield and produce milk that is unfit for consumption. The chemokine receptor CXCR1 is an excellent prospective genetic marker for mastitis resistance in cattle because it regulates neutrophil migration, killing, and survival during infe.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.July.30.10
- DOI:
- 10.4238/2013.July.30.10
Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis
Authors: S. Denden, B. Bouden, A. Haj Khelil, J. Ben Chibani and M.H. Hamdaoui
The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a meta-analysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar dat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027487
- DOI:
- 10.4238/gmr.15027487
A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil
Authors: A.V.C. Coelho, R.R. Moura, C.A.J. Cavalcanti, R.L. Guimar�£es,P. Sandrin-Garcia, S. Crovella and L.A.C. Brand�£o
Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples&rsquo.. Read More»
- Genet. Mol. Res. 14(1):
Comparative analysis of myostatin gene and promoter sequences of Qinchuan and Red Angus cattle
Authors: Y.L. He, Y.H. Wu, F.S. Quan, Y.G. Liu and Y. Zhang
To better understand the function of the myostatin gene and its promoter region in bovine, we amplified and sequenced the myostatin gene and promoter from the blood of Qinchuan and Red Angus cattle by using polymerase chain reaction. The sequences of Qinchuan and Red Angus cattle were compared with those of other cattle breeds available in GenBank. Exon s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.4.6
- DOI:
- 10.4238/2013.September.4.6
Association between a polymorphism of the �±-lactalbumin gene and milk production traits in Chinese Holstein cows
Authors: J.P. Zhou and C.H. Dong
The traits particularly important for milk production include milk yield, protein percentage, fat percentage, and the somatic cell score. Alpha-lactalbumin (α-LA) is an important whey protein of cow milk, and is also present in the milk of many other mammalian species. In this study, we analyzed the genetic polymorphisms of the α-LA gene and t.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.4.3
- DOI:
- 10.4238/2013.September.4.3
Polymorphisms in the nuclear factor kappa B gene association with recurrent embryo implantation failure
Authors: L. Luo, D.H. Li, X.P. Li, S.C. Zhang, C.F. Yan, J.F. Wu, Y.H. Qi and J. Zhao
Despite more than a century of intensive study, the mechanisms of successful pregnancy remain unclear. Recent research suggests that NF-κB (nuclear factor kappa B) plays an important role in embryo implantation. In the current study, we aimed to identify SNPs that contribute to genetic susceptibility for recurrent implan.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027759
- DOI:
- 10.4238/gmr.15027759
Identification of CD14 transcript in blood polymorphonuclear neutrophil leukocytes and functional variation in Holsteins
Authors: J.M. Huang, X.G. Wang, Q. Jiang, Y. Sun, C.H. Yang, Z.H. Ju,H.S. Hao, C.F. Wang, J.F. Zhong and H.B. Zhu
Polymorphonuclear neutrophil (PMN) leukocytes are primary phagocytic cells of the bovine mammary gland and a first line of defense against invading pathogens during bovine mastitis infection. Cluster of differentiation 14 (CD14) is mainly expressed in macrophages and neutrophils and acts as a co-receptor that binds bacterial l.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027932
- DOI:
- 10.4238/gmr.15027932
Significantly association of diabetes mellitus with CTLA-4 gene polymorphisms based on a meta-analysis of epidemiological evidence in Asians and non-Asians
Authors: J. Liu, H.X. Zhang, G.Y. Feng and L. He
We evaluated association of polymorphisms in the CTLA-4 gene with the risk of type 1 diabetes mellitus. Comprehensive meta-analysis was applied to case-control studies of the association between CTLA-4 and type 1 diabetes mellitus to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. We s.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.23.11
- DOI:
- 10.4238/2013.September.23.11
Intracranial aneurysm risk factor genes:relationship with intracranial aneurysm risk in a Chinese Han population
Authors: L.T. Zhang, F.J. Wei, Y. Zhao, Z. Zhang, W.T. Dong, Z.N. Jin, F. Gao, N.N. Gao, X.W. Cai, N.X. Li, W. Wei, F.S. Xiao, S.Y. Yue, J.N. Zhang, S.Y. Yang, W.D. Li and X.Y. Yang
Few studies have examined the genes related to risk factors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression mod.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.30
- DOI:
- 10.4238/2015.June.18.30