Snp
Factor analysis applied to genome prediction for high-dimensional phenotypes in pigs
Authors: F.R.F. Teixeira, M. Nascimento, A.C.C. Nascimento, F.F. e Silva, C.D. Cruz, C.F. Azevedo, D.M. Paix�£o, L.M.A. Barroso, L.L. Verardo, M.D.V. de Resende, S.E.F. Guimar�£es and P.S. Lopes
The aim of the present study was to propose and evaluate the use of factor analysis (FA) in obtaining latent variables (factors) that represent a set of pig traits simultaneously, for use in genome-wide selection (GWS) studies. We used crosses between outbred F2 populations of Brazilian Piau X commercial pigs. Data were obtain.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028231
- DOI:
- 10.4238/gmr.15028231
Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia
Authors: S.-Q. Ge, J. Grifin, L.-H. Liu, K.I. Aston, L. Simon, T.G. Jenkins, B.R. Emery and D.T. Carrell
Male infertility is often associated with a decreased sperm count. The Pygo2 gene is expressed in the elongating spermatid during chromatin remodeling; thus impairment in PYGO2 function might lead to spermatogenic arrest, sperm count reduction, and subsequent infertility. The aim of this study was to identify mutations in Pygo2 that might lead to idiopath.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.14
- DOI:
- 10.4238/2015.August.7.14
Impacts of single nucleotide polymorphisms and haplotypes in the bovine Dapper1 gene on body weight
Authors: J. Wang, C. Wang, Y. Gao, X.-Y. Lan, C.-Z. Lei, J.-Q. Wang and H. Chen
The Dapper1 protein plays important role in multiple developmental processes via negative modulation of the Wnt signaling pathway. We detected variations in Dapper1 in 1185 individuals from 5 Chinese cattle breeds and determined their effects on bovine body weight. Two silent mutations (g.8344C>T and g.8428C>T) in exon 6 along with two substitutions.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.17.4
- DOI:
- 10.4238/2013.April.17.4
Molecular cloning of the perilipin gene and its association with carcass and fat traits in Chinese ducks
Authors: H.L. Zhang, H.J. Fan, X.L. Liu, Y. Wu and S.S. Hou
The perilipin (PLIN) gene is a candidate gene of carcass and fat traits in ducks. In order to study the molecular character of the PLIN gene and its function in different breeds of Chinese ducks, samples were obtained from the Chinese Academy of Agricultural Sciences Research Center for Birds, including 95 Peking ducks of the Z2 series, 91 Peking ducks of.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.12
- DOI:
- 10.4238/2013.May.13.12
Serotonin receptor 2C gene polymorphism associated with post-stroke depression in Chinese patients
Authors: W.K. Tang, N. Tang, C.D. Liao, H.J. Liang, V.C.T. Mok, G.S. Ungvari and K.S. Wong
The serotonin receptor 2C (HTR2C) gene has been shown to play a pivotal role in major depression. We examined the association between post-stroke depression (PSD) and polymorphism in HTR2C. A cohort of 223 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months af.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.8
- DOI:
- 10.4238/2013.May.13.8
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis
Authors: Z Wang, M. Li, L. Li, H. Sun and X.Y. Lin
Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, includ.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.26
- DOI:
- 10.4238/2015.December.16.26
A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice
Authors: X. Wang, Z.G. Song, D.X. Huang, H. Gao, Q. Wang and Z.P. Wang
GABAA receptors are chloride channels in the brain that are activated by binding with g-aminobutyric acid (GABA). The cDNA sequences of GABAA receptor subunits from two strains of mice with different sensitivities to isoflurane were compared to identify nucleotide mutations. Included 80 mice from two strains with different sen.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027340
- DOI:
- 10.4238/gmr.15027340
Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil
Authors: P.N. Costa, H. Ferreira-Fernandes, J.S. de Oliveira, A.C.T.C. Pereira, G.R. Pinto and G.P. Ferreira
Dendritic cells (DCs) mediate the initiation of the immune response against a variety of pathogens. The DC-SIGN receptor is encoded by the gene CD209 and is expressed on the surface of DCs. It binds to mannose-rich carbohydrates and enables the recognition of bacteria, fungi, parasites, and viruses. SNP -336A/G in the promoter region of CD209 influences t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.3
- DOI:
- 10.4238/2015.August.14.3
Linkage analysis of SNPs in IGFBP-6 and its relation with the body sizes of pig
Authors: X.B. Fang, S.C. Liu, Q.Y. Wu, S.M. Li, Y.Y. Cheng, H.Y. Fu, C. Lu, D. Su, H. Yu and L.L. Hao
Insulin-like growth factor binding protein-6 (IGFBP-6) is a member of the IGFBP family, which is known to be a key factor in regulating the effect of insulin-like growth factor-2 (IGF-2) on the animal growth and development. Gene sequences of 3'-untranslated regions (UTR) and exon 4 of IGFBP-6 may influence the expression and proteolysis of IGFBP-6. In th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.27
- DOI:
- 10.4238/2015.December.16.27
Association of the VRK2 gene rs3732136 polymorphism with schizophrenia in a Northwest Chinese Han population
Authors: B. Zhang, C.Y. Gao, H.B. Zhang, B. Yang, J.F. Yin, S.G. Wei, Y.S. Zhu, X.N. Jia and S.B. Li
Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total popula.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.4
- DOI:
- 10.4238/2015.August.14.4