Snp
Identification of SNPs within the PRLR gene and effects on maternal behavior in sheep
Authors: L.P. Wang, R.Q. Geng, X.N. Zhang and W. Sun
The prolactin receptor gene (PRLR) plays an essential role in maternal behavior. The aim of the study was to detect PRLR mutations in exon 10, using a polymerase chain reaction-single stranded conformation polymorphism method, and to determine the association between mutations in this region with maternal behavior traits in Chinese Hu sheep. Polymorphisms.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.26
- DOI:
- 10.4238/2015.December.21.26
Three novel SNPs of the bovine Tf gene in Chinese native cattle and their associations with milk production traits
Authors: Z.H. Ju, Q.L. Li, J.M. Huang, M.H. Hou, R.L. Li, J.B. Li, J.F. Zhong and C.F. Wang
Transferrin (Tf) is a β-globulin protein that transports iron ions in mammalian cells. It contributes to innate immunity to microbial pathogens, primarily by limiting microbial access to iron. Thus, polymorphisms present in bovine Tf could potentially underlie inherited differences in mastitis resistance and milk producti.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1038
- DOI:
- 10.4238/vol10-1gmr1038
Genome-wide analysis of single nucleotide polymorphisms in patients with atrophic age-related macular degeneration in oldest old Han Chinese
Authors: T.Q. Zhou, H.J. Guan and J.Y. Hu
The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.13
- DOI:
- 10.4238/2015.December.21.13
Characterization of porcine GAS6 cDNA gene and its expression analysis in weaned piglets
Authors: D. Xu, J. Jiang, J. He, C.Q. He and H.M. Ma
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. A recent report has demonstrated that the GAS6 gene can promote fat deposition and is associated with an increased number of fat cells in mice. In order to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.39
- DOI:
- 10.4238/2015.December.21.39
Molecular markers located on the DGAT1, CAST, and LEPR genes and their associations with milk production and fertility traits in Holstein cattle
Authors: R. Hill, A. Canal, K. Bondioli, R. Morell and M.D. Garcia
The objective of the present study was to investigate single nucleotide polymorphisms (SNPs) located in three candidate genes previously reported to have effects on fertility and milk production traits in a population of 123 Holstein cows. The milk production traits evaluated included lifetime averages of milk yield, protein c.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017794
- DOI:
- 10.4238/gmr.15017794
APOA5 polymorphisms associated with lipid metabolism in Brazilian children and adolescents
Authors: E. De Fran�§a, D.S.B.S. Silva, T.F.C. Silva, C.L. Dornelles, J.G. Alves and C.S. Alho
Single nucleotide polymorphisms in the APOA5 gene have been studied for their association with metabolic syndrome. Thus, elucidating the effect of the mechanism involved in APOA5 gene polymorphisms on lipid metabolism is of great importance. In this study we aimed to determine the allelic and genotypic frequencies of -1131T>C, Ser19Trp, and intergenic .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017809
- DOI:
- 10.4238/gmr.15017809
Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III
Authors: J. de Azev�ªdo Silva, N.A.C. Tavares, M.M.S. Santos, R. Moura, R.L. Guimar�£es, J. Ara�ºjo, S. Crovella and L.A.C. Brand�£o
Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterized by T-cell mediated self-destruction of insulin-producing β cells in the pancreas. T1D patients are prone to develop other glandular autoimmune disorders, such as autoimmune thyroid disease that occurs simultaneously with autoimmune polyglandular syndrome type III (AP.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.46
- DOI:
- 10.4238/2015.December.21.46
Polymorphisms in the GHRL gene and their associations with traits of economic interest in beef cattle
Authors: C.U. Braz, G.M.F. Camargo, D.F. Cardoso, F.M.M. Gil, P.D.S. Fonseca, J.N.S.G. Cyrillo, M.E.Z. Mercadante, H.N. Oliveira and H. Tonhati
The hormone ghrelin is produced in the stomach wall, has an orexigenic function, stimulates growth hormone secretion, and affects the energy balance of the animal. Therefore, the ghrelin gene (GHRL) is considered to be a good candidate marker for the identification of traits of great economic importance in cattle, such as those associated with feed intake.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.6
- DOI:
- 10.4238/2015.December.23.6
Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population
Authors: J.Q. Liang, Y.G. Xi, C.Y. An and X.L. Su
Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotypin.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.9
- DOI:
- 10.4238/2015.August.21.9
A simple real-time polymerase chain reaction (PCR)-based assay for authentication of the Chinese Panax ginseng cultivar Damaya from a local ginseng population
Authors: H. Wang, J. Wang2 and G. Li
Panax ginseng is one of the most important medicinal plants in the Orient. Owing to its increasing demand in the world market, cultivated ginseng has become the main source of medicinal material. Among the Chinese ginseng cultivars, Damaya commands higher prices and is grown in significant proportions among the local ginseng p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028801
- DOI:
- 10.4238/gmr.15028801