Snp
Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control
Authors: H.R. Frigeri, I.C.R. Santos, R.R. R�©a, A.C.R. Almeida, C.M.T. Fadel-Picheth, F.O. Pedrosa, E.M. Souza, F.G.M. Rego and G. Picheth
Glucokinase (GCK) plays a key role in glucose homeostasis. Gestational diabetes mellitus increases the risk of gestational complications in pregnant women and fetuses. We screened for mutations in coding and flanking regions of the GCK gene in pregnant women with or without gestational diabetes in a Brazilian population. A sam.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.2
- DOI:
- 10.4238/2012.May.18.2
Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence
Authors: L.N. Moraes, M.F. Borges, P.A.C. Sousa, P.C. Venere and I.L. Souza
Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an unusually high incidence of .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.June.15.10
- DOI:
- 10.4238/2012.June.15.10
Mitochondrial haplogroup D4 confers resistance and haplogroup B is a genetic risk factor for high-altitude pulmonary edema among Han Chinese
Authors: Y.J. Luo W.X. Gao S.Z. Li X.W. Huang Y. Chen F.Y. Liu Q.Y. Huang Y.Q. Gao
High-altitude pulmonary edema (HAPE) is a life-threatening condition caused by acute exposure to high altitude. Accumulating evidence suggests that genetic factors play an important role in the etiology of HAPE. However, conclusions from association studies have been hindered by limited sample size due to the rareness of this disease. It is known that mitoch.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.9.1
- DOI:
- 10.4238/2012.October.9.1
Comparison of methods used to identify superior individuals in genomic selection in plant breeding
Authors: L.L. Bhering, V.S. Junqueira, L.A. Peixoto, C.D. Cruz and B.G. Laviola
The aim of this study was to evaluate different methods used in genomic selection, and to verify those that select a higher proportion of individuals with superior genotypes. Thus, F2 populations of different sizes were simulated (100, 200, 500, and 1000 individuals) with 10 replications each. These consisted of 10 linkage groups (LG) of 100 cM each, cont.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.26
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.26
Molecular characterization, tissue expression profile, and single nucleotide polymorphism analysis of the periostin gene in swine
Authors: D. Xu, H.M. Ma and D.F. Xiao
Periostin, also called osteoblast-specific factor 2, is an important regulator of bone, cardiac development, and wound healing. A recent study revealed that periostin plays an important role in tumor development and is upregulated in a wide variety of cancers. However, little is known about periostin in swine. Therefore, the cDNA sequence of the porcine p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017187
- DOI:
- 10.4238/gmr.15017187
Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins
Authors: Z.L. Zhao C.F. Wang Q.L. Li Z.H. Ju J.M. Huang J.B. Li J.F. Zhong J.B. Zhang
The mannan-binding lectin gene (MBL) participates as an opsonin in the innate immune system of mammals, and single nucleotide polymorphisms (SNPs) in MBL cause various immune dysfunctions. In this study, we detected SNPs in MBL2 at exon 1 using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chi.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.15.6
- DOI:
- 10.4238/2012.October.15.6
A missense mutant of the PPAR-�³gene associated with carcass and meat quality traits in Chinese cattle breeds
Authors: Y.Y. Fan G.W. Fu C.Z. Fu L.S. Zan W.Q. Tian
The peroxisome proliferator-activated receptor gamma (PPAR-Ã?³) is a key molecule in adipocyte differentitation; it transactivates multiple target genes in lipid metabolic pathways. Using PCR-SSCP and DNA sequencing, we evaluated a potential association of an SNP (72472 Gï¹¥T in exon7) of the bovine PPAR-Ã?³gene with carcass and meat quality traits in 6.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.August.17.4
- DOI:
- 10.4238/2012.August.17.4
Evaluation of associations between single nucleotide polymorphisms in the FRMD3 and CARS genes and diabetic nephropathy in a Kuwaiti population
Authors: S. Al-waheeb1, M. Alwohhaib2, A. Abdelghani3, S. Al-Sharrah2, E. Al-Shafey4,A. Al-Sahow4, N. Alyatama5, A.A. Dashti2 and N. Hussain3
Diabetic nephropathy is the leading cause of end-stage kidney disease in the world. Many single nucleotide polymorphisms (SNPs) have been associated with diabetic nephropathy. SNPs at the 4.1 protein ezrin, radixin, moesin domain 3 (FRMD3) and cysteinyl t-RNA synthetase (CARS) genes have a well-established relationship with diabetic nephropathy. However, .. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017619
- DOI:
- 10.4238/gmr.15017619
Transcriptional co-activator PGC-1�± gene is associated with chicken skeletal muscle fiber types..
Authors: J.T. Shu, W.J. Xu, M. Zhang, W.T. Song, Y.J. Shan, C. Song, W.Q. Zhu, X.Y. Zhang and H.F. Li
The peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α) is a candidate gene for meat quality traits because of its prominent role in muscle fiber type switching and determination. We investigated the effects of the PGC-1α gene on chicken skeletal muscle fiber type switching and on othe.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.14.19
- DOI:
- 10.4238/2014.February.14.19
Transcriptional co-activator PGC-1�± gene is associated with chicken skeletal muscle fiber types
Authors: J.T. Shu, W.J. Xu, M. Zhang, W.T. Song, Y.J. Shan, C. Song, W.Q. Zhu, X.Y. Zhang and H.F. Li
The peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α) is a candidate gene for meat quality traits because of its prominent role in muscle fiber type switching and determination. We investigated the effects of the PGC-1α gene on chicken skeletal muscle fiber type switching and on othe.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.14.19
- DOI:
- 10.4238/2014.February.14.19