Telomerase
Association of monocyte chemoattractant protein-1 rs1024611 and telomerase rs2736100 polymorphisms with susceptibility to pulmonary tuberculosis in Han Chinese population
Authors: G.H. Cheng, X.L. Wang, X.T. Yuan, Q. Xin, Q. Sun, K.L. Li, C. Sun, Z.M. Lin, Y. Luan, Y.S. Wang, F. Kong and D.W. Xu
Pulmonary tuberculosis (PTB) is caused by Mycobacterium tuberculosis infection and accumulated evidence reveals the genetic context of its infection phenotypes. Monocyte chemoattractant protein-1 (MCP-1) rs1024611 variant is shown to be associated with PTB susceptibility in some studies, but significant disparities exist. In a.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039697
- DOI:
- 10.4238/gmr16039697
Combination of multiple gene markers to detect circulating tumor cells in the peripheral blood of patients with non-small cell lung cancer using real-time PCR
Authors: M. Ding, X. Li and T. Qiu
Our study aims to determine the clinical significance of human telomerase reverse transcriptase (hTERT), S-phase kinase-associated protein 2 (Skp2) and thyroid transcription factor-1 (TTF-1) mRNA expressions in peripheral blood (PB) of patients with non-small cell lung cancer (NSCLC). Real-time polymerase chain reaction was used to investigate the gene ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.24
- DOI:
- 10.4238/2015.October.21.24
shRNA inhibits the expression of chicken telomerase reverse transcriptase in MDCC-MSB1 cells
Authors: N. Jiang, X.B. Zheng, Z.Y. Zhao, Z.G. Qin and T.J. Liu
Here, we investigated the effects of blocking chicken telomerase reverse transcriptase (chTERT) in MDCC-MSB1 cells, using small-hairpin RNAs (shRNAs) to interfere with gene expression. shRNAs specific to chTERT mRNA were designed, cloned into DNA plasmid vectors, and transfected into MDCC-MSB1 cells. The transfected chTERT RNAs were expressed by the RNA p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016979
- DOI:
- 10.4238/gmr.15016979
Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognostic significance
Authors: Gumux-Akay G, Unal AE, Bayar S, Karadayi K, Elhan AH, Sunguroqlu A and Tukun A
Telomerase activity is responsible for telomere maintenance and is believed to be crucial in most immortal cells and cancer cells; however, its clinicopathological significance in gastric cancer remains to be clarified. The aim of the present study was to assess whether malignant progression of gastric adenocarcinoma correlate.. Read More»
- Genet. Mol. Res. 6(1):
Telomere-associated factor expression in replicative senescence of human embryonic lung fibroblasts
Authors: H. Du, L. Yang, X.-Y. Xu, L. Hai, Y.-Q. Han and Y.-X. Shi
The objective of this study was to find the key regulatory molecules in the cell senescence process through observing the expression of telomere-associated factor during the normal cell replicative senescence process. Based on the established cell replicative senescence model, reverse transcription-polymerase chain reaction and western blot analyses were .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.7
- DOI:
- 10.4238/2015.August.10.7
Endometrial expression of telomerase, progesterone, and estrogen receptors during the implantation window in patients with recurrent implantation failure
Authors: N. Long, N. Liu1, X.L. Liu, J. Li, B.Y. Cai and X. Cai
Telomerase; ER alpha; RIF; Implantation window.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027849
- DOI:
- 10.4238/gmr.15027849