Tp53
Glioblastoma in a 20-year-old female patient after Chikungunya infection
Authors: L.O. Mour�£o, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves
We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»
- Genet. Mol. Res. 18(1):
Concurrent sequence variation of TP53 and TP73 genes in anaplastic astrocytoma
Authors: N.P. Anselmo, J.A. Rey, L.O. Almeida, A.C. Cust�³dio,J.R.W. Almeida, C.A. Clara, M.J. Santos and C. Casartelli
Disruption or loss of tumor suppressor gene TP53 is implicated in the development or progression of almost all different types of human malignancies. Other members of the p53 family have been identified. One member, p73, not only shares a high degree of similarity with p53 in its primary sequence, but also has similar function.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr631
- DOI:
- 10.4238/vol8-4gmr631
Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women
Authors: M.P. Gallegos-Arreola, L.E. Figuera-Villanueva, A.M. Puebla-P�©rez, H. Montoya-Fuentes, A.E. Suarez-Rincon and G.M. Z�º�±iga-Gonz�¡lez
The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.10
- DOI:
- 10.4238/2012.May.15.10
Analysis of polymorphisms in codons 11, 72 and 248 of TP53 in Brazilian women with breast cancer
Authors: B.C. Almeida1, J.P.F.O. Kleine1, C.M. Camargo-Kosugi1,2, M.R. Lisboa1,C.N. Fran�§a3, J.P. Fran�§a4 and I.D.C.G. Silva1
The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 p.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017055
- DOI:
- 10.4238/gmr.15017055
Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors
Authors: L.O. Almeida A.C. Cust�³dio G.R. Pinto M.J. Santos J.R.W. Almeida C.A. Clara J.A. Rey C. Casartelli
The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr518
- DOI:
- 10.4238/vol8-1gmr518
Influence of Arg72Pro polymorphisms of TP53 on the response of buccal cells to radiotherapy.
Authors: L. Pereira, M.R.S. Carvalho, C.G. Fonseca, S.S.S. Lima, E.M.M. Cerqueira, W. Jorge and M.C.L. Castro
Polymorphisms in the TP53 gene codon 72 (Arg72Pro) influence apoptosis induction and DNA damage repair. We evaluated how variants of protein p53 (p53Arg and p53Pro) affect cell death and DNA damage repair by analyzing the frequencies of karyorrhexis and micronuclei. There were significant differences in the frequency of karyor.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.14.6
- DOI:
- 10.4238/2011.December.14.6
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population
Authors: A.S. Sameer, Z.A. Shah, N. Syeed, M.Z. Banday, S.M. Bashir, B.A. Bhat and M.A. Siddiqi
Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to dete.. Read More»
- Genet. Mol. Res. 9(2):
- 0.4238/vol9-2gmr751
- DOI:
- 0.4238/vol9-2gmr751
Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil
Authors: G.R. Pinto, F.K.N. Yoshioka, R.L.L. Silva, C.A. Clara, M.J. Santos, J.R.W. Almeida, R.R. Burbano, J.A. Rey and C. Casartelli
The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways. A common single nucleotide polymorphism (SNP) in TP53 codon 72 (Arg72Pro) induces a 15-fold decrease of apoptosis-inducing ability and has been associat.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr415
- DOI:
- 10.4238/vol7-1gmr415
TP53 gene polymorphisms at codons 11, 72, and 248 and association with endometriosis in a Brazilian population
Authors: C.M. Camargo-Kosugi, P. D�Amora, J.P.F.O. Kleine, C.V. Carvalho, H. Sato, E. Schor and I.D.C.G. Silva
We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.26.1
- DOI:
- 10.4238/2014.August.26.1
Numerical aberrations of chromosome 17 and TP53 in brain metastases derived from breast cancer
Authors: D.S. Vasconcelos, F.P.E. da Silva, L.G. Quintana, N.P. Anselmo, M.A.K. Othman, T. Liehr and E.H.C. de Oliveira
Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor ge.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.January.4.15
- DOI:
- 10.4238/2013.January.4.15