Variant
Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population
Authors: Z.M. Zhao, C.G. Li, M.G. Hu, Y.X. Gao and R. Liu
We investigated the influence of the c.1517G>C genetic variant in the X-ray repair complementing group 1 gene (XRCC1) on pancreatic cancer (PC) susceptibility in Chinese patients. A total of 390 PC patients and 392 controls were enrolled in this case-control study. The genotypes of c.1517G>C genetic variants were determi.. Read More»
- Genet. Mol. Res. 13(2):
Molecular characterization and tissue-specific expression of invariant chain in the muscovy duck (Cairina moschata)
Authors: S.J. Liu, F.F. Chen, Y. Dai, C. Wu, Q.S. Ni and W.Y. Yu
The invariant chain (Ii) plays an important role as a chaperone for MHC II maturation and facilitates antigen presentation in vertebrates. We cloned, characterized and made a homology analysis of healthy adult muscovy duck Ii (MDIi), from a poultry farm in the suburban district of Hefei city in China, by rapid amplification of.. Read More»
- Genet. Mol. Res. 10(4):
Molecular cloning, expression and variation analyses of the dopamine D2 receptor gene in pig breeds in China
Authors: H.P. Xu, X.M. He, M.X. Fang, Y.S. Hu, X.Z. Jia, Q.H. Nie and X.Q. Zhang
The dopamine D2 receptor (DRD2) is a crucial mediator for normal physiological processes. We cloned the pig DRD2 gene, investigated its distribution in tissues and identified polymorphisms by RT-PCR, quantitative real-time PCR and direct sequencing. Two Yorkshire pigs from Guangdong Academy of Agricultural Sciences (Guangzhou,.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.December.5.6
- DOI:
- 10.4238/2011.December.5.6
Localization and expression of histone H2A variants during mouse oogenesis and preimplantation embryo development
Authors: B.J. Wu, F.L. Dong, X.S. Ma, X.G. Wang, F. Lin and H.L. Liu
Epigenetic modifications of the genome, such as histone H2A variants, ensure appropriate gene activation or silencing during oogenesis and preimplantation embryo development. We examined global localization and expression of the histone H2A variants, including H2A.Bbd, H2A.Z and H2A.X, during mouse oogenesis and preimplantatio.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.7.8
- DOI:
- 10.4238/2014.August.7.8
Expression of a novel splicing variant of Pcp2 in closely related laboratory rodents
Authors: M.A. PrzybyÃ?Â?a, M.M. Nowacka-Chmielewska and J.J. Barski
Purkinje cell protein-2 (PCP2), also known as L7, is a member of the GoLoco protein family with highly cell-specific expression, being restricted to cerebellar Purkinje cells and retinal bipolar neurons in various species. However, its function in these tissues is unknown. Previous studies have suggested that PCP2 is a guanine nucleotide dissociation inhi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038228
- DOI:
- 10.4238/gmr.15038228
Utilization of different methodologies for the characterization of Hb Hasharon heterozygotes
Authors: A.R. Chinelato-Fernandes, C.F. Mendiburu and C.R. Bonini-Domingos
Hb Hasharon has an electrophoretic mobility similar to that of Hb S in cellulose acetate and a mobility between Hb S and C at acid pH. In high-performance liquid chromatography, Hb Hasharon shows a distinct chromatographic profile and retention time. The origin of this variant is a mutation in codon 47 (GAC → CAC) of the .. Read More»
- Genet. Mol. Res. 5(1):
Luteinizing hormone receptor splicing variants in bovine Leydig cells
Authors: T.H. Ma, Q.H. Xiong, B. Yuan, H. Jiang, Y. Gao, J.B. Xu, S.Y. Liu, Y. Ding, G.L. Zhang, Y.M. Zhao and J.B. Zhang
The luteinizing hormone receptor (LHR) plays a key role in testosterone production through its interaction with the gonadotropins, LH and chorionic gonadotropin. We examined the LHR splicing pattern in bovine Leydig cells; LH-induced expression of eight cloned splicing variants was detected by real-time PCR. Luteinizing hormon.. Read More»
- Genet. Mol. Res. 11(2):
- http://dx.doi.org/2012.June.29.4
- DOI:
- http://dx.doi.org/10.4238/2012.June.29.4
Genetic variants on 17q21 are associated with asthma in a Han Chinese population
Authors: F.-X. Li, J.-Y. Tan, X.-X. Yang, Y.-S. Wu, D. Wu and M. Li
A genome-wide study has shown an association between SNPs located on 17q21 and asthma. Such associations have been identified in several populations, but little is known about the Han Chinese population. We conducted a case-control study in a Han Chinese population to investigate the relationship between SNPs located on 17q21 .. Read More»
- Genet. Mol. Res. 11(1):
- 2012.February.10.5
- DOI:
- 10.4238/2012.February.10.5
Sequence variants in the bovine PRDM16 gene associated with body weight in Chinese cattle breeds
Authors: J. Wang, C. Wang, R. Tian, Y.-Z. Huang, X.-S. Lai, X.-Y. Lan, J.-Q. Wang and H. Chen
As a zinc-finger protein, PR domain containing 16 (PRDM16) controls brown fat determination by stimulating brown fat cell production while suppressing the expression of genes for production of white fat cells; mutations in this domain are associated with myelodysplastic syndrome and leukemogenesis. In our study, polymorphisms .. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.22.5
- DOI:
- 10.4238/2012.March.22.5
Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women
Authors: Y.D. Zhang, Z. Zhang, N.F. Zhou, W.T. Jia, X.G. Cheng and X.J. Wei
Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.9
- DOI:
- 10.4238/2014.August.28.9