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Variant

Human Genetics   Research Article

Polymorphisms and allele frequencies of glutathione S-transferases A1 and P1 genes in the Polish population

Authors: M. Skrzypczak-Zielinska, O. Zakerska-Banaszak, B. Tamowicz,I. Sobieraj, N. Drweska-Matelska, M. Szalata, R. Slomski and A. Mikstacki

Glutathione S-transferases (GST) A1 and P1 are crucial enzymes involved in the biotransformation of drugs, carcinogens, and toxins, and their activity may influence drug response, susceptibility to diseases, and carcinogenesis. The genes encoding these enzymes, GSTA1 and GSTP1, have been examined in many studies because of their genetic variability, which.. Read More»

Genet. Mol. Res. 14(1):
2015.March.31.15
DOI:
10.4238/2015.March.31.15
Human Genetics   Research Article

Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population

Authors: H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu

ABSTRACT. In the present study, we aimed to investigate the association between the TNF-α -308G>A polymorphism and the risk of esophageal cancer in a Han Chinese population. The case group included 342 patients with esophageal cancer and the control group comprised 300 healthy individuals. The TNF-α -308G>A p.. Read More»

Genet. Mol. Res. 15(2):
gmr.15025866
DOI:
10.4238/gmr.15025866
Human Genetics   Research Article

Identification of CD14 transcript in blood polymorphonuclear neutrophil leukocytes and functional variation in Holsteins

Authors: J.M. Huang, X.G. Wang, Q. Jiang, Y. Sun, C.H. Yang, Z.H. Ju,H.S. Hao, C.F. Wang, J.F. Zhong and H.B. Zhu

Polymorphonuclear neutrophil (PMN) leukocytes are primary phagocytic cells of the bovine mammary gland and a first line of defense against invading pathogens during bovine mastitis infection. Cluster of differentiation 14 (CD14) is mainly expressed in macrophages and neutrophils and acts as a co-receptor that binds bacterial l.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027932
DOI:
10.4238/gmr.15027932
Microbial Genetics   Research Article

Association between rs155971 in the PCSK1 gene and the lipid profile of obese Thai children: a family-based study

Authors: S. Kulanuwat, J. Santiprabhob, B. Phonrat, C. Limwongse, A. Tungtrongchitr, N. Chongviriyaphan and R. Tungtrongchitr

Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 an.. Read More»

Genet. Mol. Res. 14(3):
2015.August.7.23
DOI:
10.4238/2015.August.7.23
Human Genetics   Research Article

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Authors: Z. Pan, Z. Fu, Q. Song, W. Cao, W. Cheng and X. Xu

Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) .. Read More»

Genet. Mol. Res. 15(2):
gmr.15028640
DOI:
10.4238/gmr.15028640
Microbial Genetics   Research Article

Association between 1p13.3 genomic markers and coronary artery disease: a meta-analysis involving patients and controls

Authors: J. Guo, Y.X. Luo, L.X. Tao1 and X.H. Guo

Recently, genome-wide association studies on cardio­vascular disease identified a series of associated single nucleotide polymorphisms in an intergenic region of chromosome 1p13.3. We in­vestigated the association of this locus with cardiovascular disease in 13 case-control studies and undertook a meta-analysis for effect size, heterogeneity, publ.. Read More»

Genet. Mol. Res. 14(3):
2015.August.7.18
DOI:
10.4238/2015.August.7.18
Microbial Genetics   Research Article

A novel variant of the �²-lactamase ADC-61 gene in multi-drug resistant Acinetobacter baumannii

Authors: Y. Zhou, S.-J. Teng, L. Yang, S.-B. Li and Y. Xu

The aim of this study was to investigate the existence of a β-lactamase gene in a group of multi-drug resistant Acinetobacter baumannii. Twenty strains of multi-drug resistant A. baumannii were isolated. Thirty-four β-lactamase genes and the ISaba1- OXA-23 linkage were analyzed in these strains by polymerase chain reaction (PCR) and verified by .. Read More»

Genet. Mol. Res. 14(2):
2015.June.29.2
DOI:
10.4238/2015.June.29.2
Human Genetics   Research Article

Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population

Authors: J.J. Jin, H.Q. Wang, H.P. Kuang, B.B. Kang, Y.H. Liu and J. Wang

Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRC.. Read More»

Genet. Mol. Res. 15(2):
gmr.15024661
DOI:
10.4238/gmr.15024661
Human Genetics   Research Article

Association between the XPG gene Asp1104His polymorphism and lung cancer risk

Authors: B. Zhou, X.M. Hu and G.Y. Wu

It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027395
DOI:
10.4238/gmr.15027395
Human Genetics   Research Article

Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer

Authors: Y. Li, A.W. Huang, Y.Z. Chen, W.J. Yang, M.T. Zhou and H.W. Sun

Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been repo.. Read More»

Genet. Mol. Res. 15(2):
gmr.15027906
DOI:
10.4238/gmr.15027906