Authors: M. Skrzypczak-Zielinska, O. Zakerska-Banaszak, B. Tamowicz,I. Sobieraj, N. Drweska-Matelska, M. Szalata, R. Slomski and A. Mikstacki
Glutathione S-transferases (GST) A1 and P1 are crucial enzymes involved in the biotransformation of drugs, carcinogens, and toxins, and their activity may influence drug response, susceptibility to diseases, and carcinogenesis. The genes encoding these enzymes, GSTA1 and GSTP1, have been examined in many studies because of their genetic variability, which.. Read More»
Authors: H. Zhao, H.W. Zhang, T. Zhang and X.M. Gu
ABSTRACT. In the present study, we aimed to investigate the association between the TNF-α -308G>A polymorphism and the risk of esophageal cancer in a Han Chinese population. The case group included 342 patients with esophageal cancer and the control group comprised 300 healthy individuals. The TNF-α -308G>A p.. Read More»
Authors: J.M. Huang, X.G. Wang, Q. Jiang, Y. Sun, C.H. Yang, Z.H. Ju,H.S. Hao, C.F. Wang, J.F. Zhong and H.B. Zhu
Polymorphonuclear neutrophil (PMN) leukocytes are primary phagocytic cells of the bovine mammary gland and a first line of defense against invading pathogens during bovine mastitis infection. Cluster of differentiation 14 (CD14) is mainly expressed in macrophages and neutrophils and acts as a co-receptor that binds bacterial l.. Read More»
Authors: S. Kulanuwat, J. Santiprabhob, B. Phonrat, C. Limwongse, A. Tungtrongchitr, N. Chongviriyaphan and R. Tungtrongchitr
Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 an.. Read More»
Authors: Z. Pan, Z. Fu, Q. Song, W. Cao, W. Cheng and X. Xu
Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) .. Read More»
Authors: J. Guo, Y.X. Luo, L.X. Tao1 and X.H. Guo
Recently, genome-wide association studies on cardiovascular disease identified a series of associated single nucleotide polymorphisms in an intergenic region of chromosome 1p13.3. We investigated the association of this locus with cardiovascular disease in 13 case-control studies and undertook a meta-analysis for effect size, heterogeneity, publ.. Read More»
Authors: Y. Zhou, S.-J. Teng, L. Yang, S.-B. Li and Y. Xu
The aim of this study was to investigate the existence of a β-lactamase gene in a group of multi-drug resistant Acinetobacter baumannii. Twenty strains of multi-drug resistant A. baumannii were isolated. Thirty-four β-lactamase genes and the ISaba1- OXA-23 linkage were analyzed in these strains by polymerase chain reaction (PCR) and verified by .. Read More»
Authors: J.J. Jin, H.Q. Wang, H.P. Kuang, B.B. Kang, Y.H. Liu and J. Wang
Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRC.. Read More»
Authors: B. Zhou, X.M. Hu and G.Y. Wu
It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects.. Read More»
Authors: Y. Li, A.W. Huang, Y.Z. Chen, W.J. Yang, M.T. Zhou and H.W. Sun
Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNALeu(CUN) has been repo.. Read More»