Human Genetics
Association between the XRCC1 Arg399Gln polymorphism and risk of cervical carcinoma: a meta-analysis
Authors: D.Y. Liu, H.C. Liang and X.M. Xiao
Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 205.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.15
- DOI:
- 10.4238/2015.August.19.15
Heat shock protein 70 polymorphisms in Chinese patients with Graves� disease
Authors: Y.P. Wang, Z. Tang, B.K. Peng,Q. Zhen, S.L. Zhou and X.F. Jin
Graves’ disease (GD) is a common autoimmune disease mainly affecting the thyroid. However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population. Therefore, the aim of this study was to investigate the association between HSP70 polymorphisms and GD in the Chinese population. A total of 153 pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.25
- DOI:
- 10.4238/2015.December.23.25
Quantitative trait locus analysis of grape weight and soluble solid content
Authors: Y.H. Zhao, Y.S. Guo, H. Lin, Z.D. Liu, H.F. Ma, X.W. Guo, K. Li, X.X. Yang, Z.Z. Niu and G.G. Shi
A grapevine hybrid population was derived from a crossing of the early-maturing female parent cultivar ‘87-1’ and the late-maturing male parent cultivar ‘9-22’. A total of 149 plants were selected from the hybrid population as the mapping population, and after sequence-related amplified polymorphism and simple-sequence repeat marke.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.21
- DOI:
- 10.4238/2015.August.19.21
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis
Authors: L.L. Zhang, Y.Q. Wang, B. Fu, S.L. Zhao and Y. Kui
We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.38
- DOI:
- 10.4238/2015.December.23.38
Association of TNF-�±, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil
Authors: N.A.C. Tavares, M.M.S. Santos, R. Moura, J. Ara�ºjo, R.L. Guimar�£es, S. Crovella and L.A.C. Brand�£o
Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polygland.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.42
- DOI:
- 10.4238/2015.December.28.42
Expression of TRAIL and its receptor DR5 and their significance in acute leukemia cells
Authors: S.M. Chen, H. Sun, Y.F. Liu, J. Ma, Q.T. Zhang, J. Zhu and T. Li
We investigated the roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor death receptor 5 (DR5) in the onset of acute leukemia and changes in their expression during chemotherapy. Bone marrow samples from 16 patients newly diagnosed with acute leukemia were collected before chemotherapy. Bone marrow samples from patien.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.3
- DOI:
- 10.4238/2015.December.28.3
Genetic diversity of popcorn genotypes using molecular analysis
Authors: F.S. Resh, C.A. Scapim, C.A. Mangolin, M.F.P.S. Machado, A.T. do Amaral Jr., H.C.C. Ramos and M. Vivas
In this study, we analyzed dominant molecular markers to estimate the genetic divergence of 26 popcorn genotypes and evaluate whether using various dissimilarity coefficients with these dominant markers influences the results of cluster analysis. Fifteen random amplification of polymorphic DNA primers produced 157 amplified fragments, of which 65 were mon.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.16
- DOI:
- 10.4238/2015.August.19.16
Genetic analysis of maize kernel thickness by quantitative trait locus identification
Authors: S.S. Wen, G.Q. Wen, C.M. Liao and X.H. Liu
Kernel thickness is one of the most important traits in kernel structure, and is related to yield. To ascertain its genetic information more clearly, an immortal recombinant inbred line segregation population was used to map the quantitative trait loci (QTLs) for kernel thickness. As a result, two QTLs were identified on chromosome 9; both of them had neg.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.19
- DOI:
- 10.4238/2015.August.19.19
APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease
Authors: Y. Sun, R.B. Zhou and D.M. Chen
The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to thes.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.9
- DOI:
- 10.4238/2015.December.23.9
Topological centrality-based identification of hub genes and pathways associated with acute viral respiratory infection in infants
Authors: X.Y. Liu, G.Q. Li, Y. Ma and L.J. Zhao
The objective of this study was to identify hub genes and pathways associated with acute respiratory infection (ARI) in infants based on gene expression profiles. Differentially expressed genes (DEGs) between ARI and normal (controls) infants were identified based on linear modeling of the microarray data using Limma package. A protein-protein interaction.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.21
- DOI:
- 10.4238/2015.December.23.21